Brognard John相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Tumor-Specific Pro-Thrombotic Gene Expression in Head and Neck Squamous Cell Carcinoma: A Multi-Cohort Transcriptomic Analysis

头颈部鳞状细胞癌中肿瘤特异性促血栓基因表达：一项多队列转录组分析

影响因子:4.4

doi:10.3390/cancers18071055

Arnold, Kiranya E; Debick, Nadia; Brognard, John; Ghosh, Auyon J

细胞生物学

发表日期：2026

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PIM kinase inhibition attenuates pro-tumoral and immunosuppressive functions of macrophages in classic Hodgkin lymphoma

PIM激酶抑制剂可减弱经典霍奇金淋巴瘤中巨噬细胞的促肿瘤和免疫抑制功能

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08402-5

Szydłowski, Maciej; Kurtz, Ewa; Garbicz, Filip; Maroszek, Julia; Pawlak, Michał; Ochocka, Natalia; Tabaka, Marcin; Prochorec-Sobieszek, Monika; Szumera-Ciećkiewicz, Anna; Górniak, Patryk; Szymańska-Giemza, Olga; Rymkiewicz, Grzegorz; Kołkowska-Leśniak, Agnieszka; Kukwa, Wojciech; Paszkiewicz-Kozik, Ewa; Totoń-Żurańska, Justyna; Radomska, Sylwia; Pilch, Zofia; Nowis, Dominika; Golab, Jakub; Kurlapski, Michał; Zaucha, Jan Maciej; Braczko, Alicja; Kaszkowiak, Marcin; Wołkow, Paweł; Wiktorska, Katarzyna; Brognard, John; Lichołai, Sabina; Lech-Marańda, Ewa; Juszczyński, Przemysław

细胞生物学

免疫/内分泌

发表日期：2025

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CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor-driven proteome through PARP7 activity.

CRISPR 筛选和定量蛋白质组学揭示了通过 PARP7 活性重塑芳烃受体驱动的蛋白质组

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2424985122

Gorelik Andrii, Paulo Joao A, Schroeter Christina B, Lad Melanie, Shurr Abigail, Mastrokalou Chara, Siddiqi Samrah, Suyari Osamu, Brognard John, Walter David, Matthews Jason, Palmer Timothy M, Gygi Steven P, Ahel Ivan

发表日期：2025

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Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.

通过抑制或降解激酶 LZK 来靶向 c-MYC 和获得功能的 p53，可以抑制 HNSCC 肿瘤的生长

期刊:Science Signaling

影响因子:6.6

doi:10.1126/scisignal.ado2857

Funk Amy L, Katerji Meghri, Afifi Marwa, Nyswaner Katherine, Woodroofe Carolyn C, Edwards Zoe C, Lindberg Eric, Bergman Knickole L, Gough Nancy R, Rubin Maxine R, KarpiÅska Kamila, Trotter Eleanor W, Dash Sweta, Ries Amy L, James Amy, Robinson Christina M, Difilippantonio Simone, Karim Baktiar O, Chang Ting-Chia, Chen Li, Xu Xin, Doroshow James H, Ahel Ivan, Marusiak Anna A, Swenson Rolf E, Cappell Steven D, Brognard John

发表日期：2025

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Defeating kinases that promote tumorigenesis through non-catalytic functions with PROTACs - PIM kinase as an example

利用PROTACs抑制通过非催化功能促进肿瘤发生的激酶——以PIM激酶为例

期刊:Expert Opinion on Therapeutic Targets

影响因子:4.4

doi:10.1080/14728222.2025.2500418

Torres-Ayuso, Pedro; Brognard, John

发表日期：2025

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The SRC family kinase inhibitor NXP900 demonstrates potent antitumor activity in squamous cell carcinomas

SRC家族激酶抑制剂NXP900在鳞状细胞癌中表现出强大的抗肿瘤活性。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2024.107615

Dash, Sweta; Hanson, Sabrina; King, Ben; Nyswaner, Katherine; Foss, Kelcie; Tesi, Noelle; Harvey, Mungo J B; Navarro-Marchal, Saúl A; Woods, Allison; Poradosu, Enrique; Unciti-Broceta, Asier; Carragher, Neil O; Brognard, John

细胞生物学

发表日期：2024

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Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.

通过抑制或降解 LZK 靶向 GOF p53 和 c-MYC 可抑制头颈部肿瘤生长

doi:10.1101/2024.11.19.623840

Funk Amy L, Katerji Meghri, Afifi Marwa, Nyswaner Katherine, Woodroofe Carolyn C, Edwards Zoe C, Lindberg Eric, Bergman Knickole L, Gough Nancy R, Rubin Maxine R, KarpiÅska Kamila, Trotter Eleanor W, Dash Sweta, Ries Amy L, James Amy, Robinson Christina M, Difilippantonio Simone, Karim Baktiar O, Chang Ting-Chia, Chen Li, Xu Xin, Doroshow James H, Ahel Ivan, Marusiak Anna A, Swenson Rolf E, Cappell Steven D, Brognard John

发表日期：2024

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Degraders: The Ultimate Weapon Against Amplified Driver Kinases in Cancer

降解酶：对抗癌症中过度激活的驱动激酶的终极武器

期刊:Molecular Pharmacology

doi:10.1124/molpharm.121.000306

Torres-Ayuso, Pedro; Brognard, John

发表日期：2022

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Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells

MLK4 的上调促进乳腺癌细胞的迁移和侵袭能力。

期刊:Oncogene

影响因子:7.3

doi:10.1038/s41388-018-0618-0

Marusiak, Anna A; Prelowska, Monika K; Mehlich, Dawid; Lazniewski, Michal; Kaminska, Klaudia; Gorczynski, Adam; Korwat, Aleksandra; Sokolowska, Olga; Kedzierska, Hanna; Golab, Jakub; Biernat, Wojciech; Plewczynski, Dariusz; Brognard, John; Nowis, Dominika

细胞生物学

发表日期：2019

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Orange is the new black: Kinases are the new master regulators of tumor suppression

橙色是新的黑色：激酶是肿瘤抑制的新主调控因子

期刊:IUBMB Life

影响因子:3.2

doi:10.1002/iub.1981

An, Elvira; Brognard, John

发表日期：2019

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