日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors

基于结构的KRAS G12D高效选择性抑制剂的设计与合成

Cheng, Hengmiao; Li, Puhui; Chen, Ping; Irimia, Adriana; Bae, Jae Hyun; Brooun, Alexei; Fagan, Patrick; Lam, Richard; Lin, Bingzhen; Zhang, Jingchuan; Zhan, Xuejun; Wu, Xu; Xie, Nan; Chiang, Gary; Shoemaker, Robert; Vernier, Jean-Michel

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

激活B因子:激活ALK突变可增加未磷酸化激酶的蛋白质动力学

Johnson, Ted W; Bolanos, Ben; Brooun, Alexei; Gallego, Rebecca A; Gehlhaar, Dan; Jalaie, Mehran; McTigue, Michele; Timofeevski, Sergei

Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib

恢复 B 因子:回顾性标准化 B 因子分析 c-ros 癌基因 1 受体酪氨酸激酶和间变性淋巴瘤激酶 L1196M 与克唑替尼和劳拉替尼的相互作用

Johnson, Ted W; Gallego, Rebecca A; Brooun, Alexei; Gehlhaar, Dan; McTigue, Michele

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

CXCR4趋化因子GPCR与小分子和环肽拮抗剂的结构

Wu, Beili; Chien, Ellen Y T; Mol, Clifford D; Fenalti, Gustavo; Liu, Wei; Katritch, Vsevolod; Abagyan, Ruben; Brooun, Alexei; Wells, Peter; Bi, F Christopher; Hamel, Damon J; Kuhn, Peter; Handel, Tracy M; Cherezov, Vadim; Stevens, Raymond C

Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.

EphB2 受体与拮抗肽复合物的三维结构揭示了一种新的抑制模式

Chrencik Jill E, Brooun Alexei, Recht Michael I, Nicola George, Davis Leila K, Abagyan Ruben, Widmer Hans, Pasquale Elena B, Kuhn Peter

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression

通过将细胞表面检测与小规模并行表达相结合,对杆状病毒系统中的膜蛋白变体进行分析。

Hanson, Michael A; Brooun, Alexei; Baker, Kent A; Jaakola, Veli-Pekka; Roth, Chris; Chien, Ellen Y T; Alexandrov, Alexander; Velasquez, Jeffrey; Davis, Leila; Griffith, Mark; Moy, Kin; Ganser-Pornillos, Barbie K; Hua, Yuanzi; Kuhn, Peter; Ellis, Sam; Yeager, Mark; Stevens, Raymond C

Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex

结构蛋白质组学中的补救策略:Vav1/Rac1复合物的表达、纯化和结晶

Brooun, Alexei; Foster, Scott A; Chrencik, Jill E; Chien, Ellen Y T; Kolatkar, Anand R; Streiff, Markus; Ramage, Paul; Widmer, Hans; Weckbecker, Gisbert; Kuhn, Peter

Crystal structures of active fully assembled substrate- and product-bound complexes of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) from Haemophilus influenzae

流感嗜血杆菌UDP-N-乙酰胞壁酸:L-丙氨酸连接酶(MurC)活性完全组装的底物和产物结合复合物的晶体结构

Mol, Clifford D; Brooun, Alexei; Dougan, Douglas R; Hilgers, Mark T; Tari, Leslie W; Wijnands, Robert A; Knuth, Mark W; McRee, Duncan E; Swanson, Ronald V

The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode

莽草酸脱氢酶 (AroE) 的晶体结构揭示了一种独特的 NADPH 结合模式

Ye, Sheng; Von Delft, Frank; Brooun, Alexei; Knuth, Mark W; Swanson, Ronald V; McRee, Duncan E