日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rare genetic diseases associated with G-quadruplex-induced replication stress

与G-四链体诱导的复制压力相关的罕见遗传疾病

Herr, Lauren M; Mukhopadhyay, Swagata; Anderson, Olivia M; Couch, Tucker H; Jones, Cate M; Brosh, Robert M Jr; Rossi, Martina

DNA2 and MSH2 cooperatively repair stabilized G4 and allow efficient telomere replication.

DNA2 和 MSH2 协同修复稳定的 G4,并实现有效的端粒复制。

Fernandez Anthony, Zhou Tingting, Lei Yi, Liu Nian, Esworthy Steven, Shen Changxian, Liu Helen, Hess Jessica D, Yuan Hang, Shi Guojun, Zhou Mian, Shen Lei, Zhang Sufang, Kosiyatrakul Settapong, Gaur Vikas, Sommers Joshua A, Srivastava Nityanand, Edelmann Winfried, Li Guo-Min, Brosh Robert M Jr, Chai Weihang, Lee Marietta Y W T, Zhang Dong, Schildkraut Carl, Zheng Li, Shen Binghui

SARS-CoV-2 point mutations are over-represented in terminal loops of RNA stem-loop structures that can be resolved by Nsp13 helicase in a unique manner with respect to nucleotide dependence.

SARS-CoV-2 点突变在 RNA 茎环结构的末端环中过度出现,而 Nsp13 解旋酶可以以一种独特的方式解析这些结构,这种解析方式与核苷酸依赖性有关。

Dumm Adaira J, Zheng Andrew Y, Butler Thomas J, Kulikowicz Tomasz, George Joe C, Bombard Pierce T, Sommers Joshua A, Ding Jun, Brosh Robert M Jr

Discovery of thiacyanine dyes as a new class of potent coronavirus inhibitors that suppress viral RNA synthesis

发现硫氰酸染料是一类新型强效冠状病毒抑制剂,可抑制病毒RNA合成

Zhang, Tianyi; Altouma, Valerie; Sommers, Joshua A; Dumm, Adaira J; Kennedy, Debbie; Xia, Hongjie; Yang, Mo; Fullenkamp, Christopher R; Huang, Shar-Yin N; Xue, Yutong; Su, Shuaikun; Shen, Weiping; Haren, Caitlin E; Kulikowicz, Tomasz; Pommier, Yves; Schneekloth, John S Jr; Garcia-Blanco, Mariano A; Brosh, Robert M Jr; Wang, Weidong

Replication stress as a driver of cellular senescence and aging

复制压力是细胞衰老和老化的驱动因素

Herr, Lauren M; Schaffer, Ethan D; Fuchs, Kathleen F; Datta, Arindam; Brosh, Robert M Jr

Purification and biochemical characterization of the G4 resolvase and DNA helicase FANCJ.

G4 分解酶和 DNA 解旋酶 FANCJ 的纯化和生化特性分析

Kulikowicz Tomasz, Sommers Joshua A, Fuchs Kathleen F, Wu Yuliang, Brosh Robert M Jr

Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease

新发现的遗传性RECQ解旋酶疾病RECON综合征表明,复制应激反应和基因组稳态是衰老和年龄相关疾病的核心重要过程。

Datta, Arindam; Sommers, Joshua A; Jhujh, Satpal S; Harel, Tamar; Stewart, Grant S; Brosh, Robert M Jr

Editorial: DNA repair and interventions in aging

社论:DNA修复与衰老干预

Brosh, Robert M Jr; Moskalev, Alexey; Gorbunova, Vera

Frontiers in aging special issue: DNA repair and interventions in aging perspective on "loss of epigenetic information as a cause of mammalian aging"

衰老前沿特刊:DNA修复和衰老干预视角下的“表观遗传信息丢失是哺乳动物衰老的原因”

Schaffer, Ethan D; Beerman, Isabel; de Cabo, Rafael; Brosh, Robert M Jr

Biochemical analysis of DNA synthesis blockage by G-quadruplex structure and bypass facilitated by a G4-resolving helicase

G-四链体结构阻滞DNA合成的生化分析及G4解旋酶介导的旁路作用

Sommers, Joshua A; Estep, Katrina N; Maul, Robert W; Brosh, Robert M Jr