Brothers Holly M相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Evaluation of cognitive, functional, and behavioral effects observed in EMERGE, a phase 3 trial of aducanumab in people with early Alzheimer's disease

对 EMERGE 研究中观察到的认知、功能和行为效应进行评估，EMERGE 是一项针对早期阿尔茨海默病患者的 aducanumab 三期临床试验。

期刊:Alzheimers & Dementia

影响因子:11.1

doi:10.1002/alz.70224

Cummings, Jeffrey; Cohen, Sharon; Murphy, Jennifer; Brothers, Holly M; Nejati, Mina; Forrestal, Fiona; de Moor, Carl; O'Gorman, John; Harrison, John; Jaeger, Judith; Mummery, Catherine Jane; Porsteinsson, Anton P; Potashman, Michele; Tian, Ying; Yang, Lili; He, Ping; Haeberlein, Samantha Budd

阿尔茨海默症

发表日期：2025

文献求助收藏

Lower baseline amyloid beta burden is associated with greater percent of amyloid beta positron emission tomography reduction and better clinical outcomes in the aducanumab Phase 3 trials ENGAGE and EMERGE in early Alzheimer's disease

在早期阿尔茨海默病中，较低的基线β-淀粉样蛋白负荷与β-淀粉样蛋白正电子发射断层扫描（PET）降低百分比更高以及aducanumab III期临床试验ENGAGE和EMERGE中更好的临床结果相关。

期刊:Jpad-Journal of Prevention of Alzheimers Disease

影响因子:7.8

doi:10.1016/j.tjpad.2025.100202

Burton, Jackson; Brothers, Holly M; Hutchison, R Matthew; Murphy, Jennifer; Sun, Tao; Dent, Gersham; Curiale, Gioacchino; Kowalski, Ken

阿尔茨海默症

发表日期：2025

文献求助收藏

Consequences of redefining Alzheimer's disease in terms of amyloid burden without regard to cognitive decline

若不考虑认知衰退，仅根据淀粉样蛋白负荷重新定义阿尔茨海默病，其后果将不堪设想。

期刊:Neural Regeneration Research

影响因子:6.7

doi:10.4103/1673-5374.241456

Robinson, Stephen R; Brothers, Holly M; Gosztyla, Maya L

阿尔茨海默症

发表日期：2018

文献求助收藏

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease

β-淀粉样蛋白的生理作用提示治疗阿尔茨海默病的新途径

期刊:Frontiers in Aging Neuroscience

影响因子:4.5

doi:10.3389/fnagi.2018.00118

Brothers, Holly M; Gosztyla, Maya L; Robinson, Stephen R

阿尔茨海默症

发表日期：2018

文献求助收藏

Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

从M1型神经炎症表型向混合型神经炎症表型的转变会增加APP/PS1转基因小鼠体内的淀粉样蛋白沉积。

期刊:Journal of Neuroinflammation

影响因子:10.1

doi:10.1186/1742-2094-11-127

Weekman, Erica M; Sudduth, Tiffany L; Abner, Erin L; Popa, Gabriel J; Mendenhall, Michael D; Brothers, Holly M; Braun, Kaitlyn; Greenstein, Abigail; Wilcock, Donna M

发表日期：2014

文献求助收藏

β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

在APP/PS1转基因小鼠中诱导高同型半胱氨酸血症时，β-淀粉样蛋白沉积转移到血管系统，记忆障碍加剧。

期刊:Alzheimers Research & Therapy

影响因子:7.6

doi:10.1186/alzrt262

Sudduth, Tiffany L; Weekman, Erica M; Brothers, Holly M; Braun, Kaitlyn; Wilcock, Donna M

发表日期：2014

文献求助收藏

Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem.

年龄和炎症环境持续时间对中脑和脑干中的神经免疫反应和儿茶酚胺能神经元的影响各不相同

期刊:Neurobiology of Aging

影响因子:3.5

doi:10.1016/j.neurobiolaging.2013.11.006

Bardou Isabelle, Kaercher Roxanne M, Brothers Holly M, Hopp Sarah C, Royer Sarah, Wenk Gary L

发表日期：2014

文献求助收藏

Age-associated alterations in the time-dependent profile of pro- and anti-inflammatory proteins within the hippocampus in response to acute exposure to interleukin-1β

年龄相关的海马内促炎和抗炎蛋白的时间依赖性表达谱在急性暴露于白细胞介素-1β后的变化

期刊:Journal of Neuroimmunology

影响因子:2.5

doi:10.1016/j.jneuroim.2013.12.010

Hopp, Sarah C; Royer, Sarah; Brothers, Holly M; Kaercher, Roxanne M; D'Angelo, Heather; Bardou, Isabelle; Wenk, Gary L

细胞生物学

发表日期：2014

文献求助收藏

Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus.

持续时间和年龄对海马神经炎症后果的不同影响

期刊:Neurobiology of Aging

影响因子:3.5

doi:10.1016/j.neurobiolaging.2013.03.034

Bardou Isabelle, Brothers Holly M, Kaercher Roxanne M, Hopp Sarah C, Wenk Gary L

发表日期：2013

文献求助收藏

Time-Dependent Compensatory Responses to Chronic Neuroinflammation in Hippocampus and Brainstem: The Potential Role of Glutamate Neurotransmission

海马和脑干对慢性神经炎症的时间依赖性补偿反应：谷氨酸神经传递的潜在作用

doi:10.4172/2161-0460.1000110

Brothers, Holly M; Bardou, Isabelle; Hopp, Sarah C; Marchalant, Yannick; Kaercher, Roxanne M; Turner, Sarah M; Mitchem, Mollie R; Kigerl, Kristina; Wenk, Gary L

发表日期：2013

文献求助收藏