日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

宿主来源的白细胞介素-1α通过重编程肿瘤相关髓系细胞来驱动肿瘤免疫抑制。

Keerthi Raja Manikanda Raja, Gupta Gourab, Atkinson Grace, Kathrein Katie, Armstrong Alissa, Gower R Michael, Roninson Igor B, Broude Eugenia V, Chen Mengqian, Ji Hao, Lim Chang-Uk, Wang Hongjun, Fan Daping, Xu Peisheng, Li Jie, Zhou Gang, Chen Hexin

Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 mediator kinase inhibition

CDK8/19介导激酶抑制可以克服卵巢癌的抗凋亡和转移。

Monavarian, Mehri; Rajkarnikar, Resha; Page, Emily Faith; Kumari, Asha; Quintero Macias, Liz; Massicano, Felipe; Lee, Nam Y; Sahoo, Sarthak; Hempel, Nadine; Jolly, Mohit Kumar; Ianov, Lara; Worthey, Elizabeth; Singh, Abhyudai; Roninson, Igor B; Broude, Eugenia V; Chen, Mengqian; Mythreye, Karthikeyan

CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells.

CDK8/19 抑制可减弱 BCR-ABL 拮抗剂诱导的 G1 期阻滞,并加速慢性粒细胞白血病细胞的死亡

Khamidullina Alvina I, Yastrebova Margarita A, Bruter Alexandra V, Nuzhina Julia V, Vorobyeva Nadezhda E, Khrustaleva Anastasia M, Varlamova Ekaterina A, Tyakht Alexander V, Abramenko Iaroslav E, Ivanova Ekaterina S, Zamkova Maria A, Li Jing, Lim Chang-Uk, Chen Mengqian, Broude Eugenia V, Roninson Igor B, Shtil Alexander A, Tatarskiy Victor V

Targeting Mediator Kinase Cyclin-Dependent Kinases 8/19 Potentiates Chemotherapeutic Responses, Reverses Tumor Growth, and Prolongs Survival from Ovarian Clear Cell Carcinoma.

靶向介导激酶细胞周期蛋白依赖性激酶 8/19 可增强化疗反应,逆转肿瘤生长,延长卵巢透明细胞癌患者的生存期

Barton Wade C, Kumari Asha, Mack Zachary T, Schools Gary P, Quintero Liz Macias, Choi Alex Seok, Rangavajhula Karthik, Arend Rebecca C, Broude Eugenia V, Mythreye Karthikeyan

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

介质激酶抑制剂可逆转晚期前列腺癌的去势抵抗性

Li, Jing; Hilimire, Thomas A; Liu, Yueying; Wang, Lili; Liang, Jiaxin; Gyorffy, Balazs; Sikirzhytski, Vitali; Ji, Hao; Zhang, Li; Cheng, Chen; Ding, Xiaokai; Kerr, Kendall R; Dowling, Charles E; Chumanevich, Alexander A; Mack, Zachary T; Schools, Gary P; Lim, Chang-Uk; Ellis, Leigh; Zi, Xiaolin; Porter, Donald C; Broude, Eugenia V; McInnes, Campbell; Wilding, George; Lilly, Michael B; Roninson, Igor B; Chen, Mengqian

Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors

介导激酶抑制剂可抑制三阴性乳腺癌的生长,并延长mTOR和AKT抑制剂的肿瘤抑制作用。

Ding, Xiaokai; Liang, Jiaxin; Sharko, Amanda C; Hilimire, Thomas A; Li, Jing; Loskutov, Jürgen; Mack, Zachary T; Ji, Hao; Schools, Gary P; Cai, Chao; Pugacheva, Elena N; Chen, Mengqian; Roninson, Igor B; Broude, Eugenia V

Suppression of HIV-TAT and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters

细胞穿透性衣康酸酯抑制 HIV-TAT 和可卡因引起的神经毒性和炎症

B Celia Cui #, Marina Aksenova #, Aliaksandra Sikirzhytskaya, Diana Odhiambo, Elizaveta Korunova, Vitali Sikirzhytski, Hao Ji, Diego Altomare, Eugenia Broude, Norma Frizzell, Rosemarie Booze, Michael D Wyatt, Michael Shtutman

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

宿主来源的白细胞介素1α通过调节单核细胞向巨噬细胞的分化诱导免疫抑制性肿瘤微环境。

Raja, Manikanda Raja Keerthi; Gupta, Gourab; Atkinson, Grace; Kathrein, Katie; Armstrong, Alissa; Gower, Michael; Roninson, Igor; Broude, Eugenia; Chen, Menqiang; Ji, Hao; Lim, Changuk; Wang, Hongjun; Fan, Daping; Xu, Peisheng; Li, Jie; Zhou, Gang; Chen, Hexin

Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes.

抑制细胞周期蛋白依赖性激酶 8/19 可限制单核细胞中细菌和病毒诱导的炎症反应

Kokinos Elena K, Tsymbal Sergey A, Galochkina Anastasia V, Bezlepkina Svetlana A, Nikolaeva Julia V, Vershinina Sofia O, Shtro Anna A, Tatarskiy Victor V, Shtil Alexander A, Broude Eugenia V, Roninson Igor B, Dukhinova Marina

RASSF1 is identified by transcriptome coordination analysis as a target of ATF4

转录组协调分析确定 RASSF1 是 ATF4 的靶标

Youwen Zhang, Kim-Tuyen Huynh-Dam, Xiaokai Ding, Vitali Sikirzhytski, Chang-Uk Lim, Eugenia Broude, Hippokratis Kiaris