Brouillet Emmanuel相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Modeling the effects of Huntington's disease on age-related genes reveals CXXC4 as an epigenetic target to restore health and excitability of Drd1-expressing striatal neurons

通过模拟亨廷顿病对年龄相关基因的影响，发现 CXXC4 是一个表观遗传靶点，可以恢复表达 Drd1 的纹状体神经元的健康和兴奋性。

doi:10.64898/2025.12.12.693965

Arrieta-Lobo, Maialen; Farina, Francesca; Aboy, Tamara Monteagudo; Mair, Megan; Mendoza, Cloé; Tran, Huy; Aaronson, Jeff; Rosinski, Jim; Ellerby, Lisa; Brouillet, Emmanuel; Botas, Juan; Neri, Christian; Megret, Lucile

发表日期：2025

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Longitudinal MRI and 1H-MRS study of SCA7 mouse forebrain reveals progressive multiregional atrophy and early brain metabolite changes indicating early neuronal and glial dysfunction

对SCA7小鼠前脑的纵向MRI和1H-MRS研究揭示了进行性多区域萎缩和早期脑代谢物变化，表明早期神经元和胶质细胞功能障碍。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0296790

Pérot, Jean-Baptiste; Niewiadomska-Cimicka, Anna; Brouillet, Emmanuel; Trottier, Yvon; Flament, Julien

细胞生物学

发表日期：2024

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Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the "better" may become the "enemy of the good" in the course of evolution

亨廷顿蛋白中多聚谷氨酰胺序列的极端保守性与神经发育功能相关：在进化过程中，“更好”的序列可能变成“好的敌人”。

期刊:Cell Death and Differentiation

影响因子:15.4

doi:10.1038/s41418-021-00927-4

Brouillet, Emmanuel

发育与干细胞

发表日期：2022

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Precision machine learning to understand micro-RNA regulation in neurodegenerative diseases

利用精准机器学习了解神经退行性疾病中的microRNA调控

期刊:Frontiers in Molecular Neuroscience

影响因子:3.8

doi:10.3389/fnmol.2022.914830

Mégret, Lucile; Mendoza, Cloé; Arrieta Lobo, Maialen; Brouillet, Emmanuel; Nguyen, Thi-Thanh-Yen; Bouaziz, Olivier; Chambaz, Antoine; Néri, Christian

发表日期：2022

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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington's disease reveals early gray and white matter alterations

对亨廷顿病基因敲入小鼠模型进行纵向多模态磁共振成像表征，揭示了早期灰质和白质的改变

期刊:Human Molecular Genetics

影响因子:3.2

doi:10.1093/hmg/ddac036

Pérot, Jean-Baptiste; Célestine, Marina; Palombo, Marco; Dhenain, Marc; Humbert, Sandrine; Brouillet, Emmanuel; Flament, Julien

发表日期：2022

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The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease

LRRK2 与 α-突触核蛋白在帕金森病中出人意料的合作

期刊:European Journal of Neuroscience

影响因子:2.4

doi:10.1111/ejn.14182

Cresto, Noémie; Gardier, Camille; Gubinelli, Francesco; Gaillard, Marie-Claude; Liot, Géraldine; West, Andrew B; Brouillet, Emmanuel

发表日期：2019

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Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat

增强神经纤维缠结的形成可降低可溶性tau蛋白在大鼠体内的急性毒性

影响因子:11.7

doi:10.1093/brain/awx342

d'Orange, Marie; Aurégan, Gwénaelle; Cheramy, Dimitri; Gaudin-Guérif, Mylène; Lieger, Sarah; Guillermier, Martine; Stimmer, Lev; Joséphine, Charlène; Hérard, Anne-Sophie; Gaillard, Marie-Claude; Petit, Fanny; Kiessling, Maren Christine; Schmitz, Christoph; Colin, Morvane; Buée, Luc; Panayi, Fany; Diguet, Elsa; Brouillet, Emmanuel; Hantraye, Philippe; Bemelmans, Alexis-Pierre; Cambon, Karine

发表日期：2018

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Contribution of Neuroepigenetics to Huntington's Disease

神经表观遗传学对亨廷顿病的影响

期刊:Frontiers in Human Neuroscience

影响因子:2.7

doi:10.3389/fnhum.2017.00017

Francelle, Laetitia; Lotz, Caroline; Outeiro, Tiago; Brouillet, Emmanuel; Merienne, Karine

发表日期：2017

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Evidence for a "metabolically inactive" inorganic phosphate pool in adenosine triphosphate synthase reaction using localized 31P saturation transfer magnetic resonance spectroscopy in the rat brain at 11.7 T

利用11.7 T大鼠脑内局部31P饱和转移磁共振波谱法，证实了腺苷三磷酸合成酶反应中存在“代谢不活跃”的无机磷酸盐池。

期刊:Journal of Cerebral Blood Flow and Metabolism

影响因子:4.5

doi:10.1177/0271678X16657095

Tiret, Brice; Brouillet, Emmanuel; Valette, Julien

发表日期：2016

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The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study

神经保护剂CNTF可降低大鼠纹状体神经元代谢物：一项体内多模态磁共振成像研究

期刊:Journal of Cerebral Blood Flow and Metabolism

影响因子:4.5

doi:10.1038/jcbfm.2015.48

Carrillo-de Sauvage, Maria-Angeles; Flament, Julien; Bramoulle, Yann; Ben Haim, Lucile; Guillermier, Martine; Berniard, Aurélie; Aurégan, Gwennaëlle; Houitte, Diane; Brouillet, Emmanuel; Bonvento, Gilles; Hantraye, Philippe; Valette, Julien; Escartin, Carole

发表日期：2015

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