日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure

比较纳入胎盘转运的二甲双胍生理药代动力学模型以预测胎儿和母体暴露量

Tiley, Jacqueline B; Hartauer, Mattie E; Whigham, Tajhia L; Mendes, Maïlys De Sousa; Brouwer, Kim L R; Hebert, Mary F

Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model

肥胖和MASH对肝细胞区域性他汀类药物暴露的影响:基于渗透性受限多室肝脏模型的药效学见解

Murphy, William A; Sjöstedt, Noora; Mendes, Mailys De Sousa; Hartauer, Mattie; Brouwer, Kim L R; Neuhoff, Sibylle

Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity.

具有体内抗甲病毒活性的共价nsP2蛋白酶抑制剂的物种依赖性代谢

Hossain Mohammad Anwar, Mayo Abigail K, Ghoshal Anirban, Taft-Benz Sharon, Anderson Elizabeth, Morales Noah L, Pressey Katia D, Vargason Ava, Brouwer Kim L R, Moorman Nathaniel J, Heise Mark T, Willson Timothy M

Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters

评估人类三维多细胞肝球体模型作为研究肝脏转运蛋白的平台

Hartauer, Mattie; Ho, Henry; Wan, Meimei; Murphy, William A; Tiley, Jacqueline B; Fallon, John K; Bishop, Colin E; Brouwer, Kim L R

Understanding Coproporphyrins and Their Disposition: Coproporphyrinuria is Common, of Diverse Cause, and Rarely Indicates Porphyria

了解粪卟啉及其代谢:粪卟啉尿症很常见,病因多样,但很少提示卟啉症。

Bonkovsky, Herbert L; Ma, Christopher D; Araque, Manuela; Tiley, Jacqueline B; Brouwer, Kim L R; Stölzel, Ulrich

Development of an in vitro metabolic dysfunction-associated steatohepatitis model to investigate altered drug metabolizing enzymes, transport proteins, and hepatobiliary disposition

建立体外代谢功能障碍相关脂肪性肝炎模型,以研究药物代谢酶、转运蛋白和肝胆处置的改变

Murphy, William A; Kyburz, Sarina; Ho, Henry; Loop, Matthew Shane; Fallon, John K; Tiley, Jacqueline B; Kralj, Thomas; Brouwer, Kim L R

Altered bile acid and coproporphyrin-I disposition in patients with autosomal dominant polycystic kidney disease

常染色体显性多囊肾病患者胆汁酸和粪卟啉-I代谢改变

Tiley, Jacqueline B; Beaudoin, James J; Derebail, Vimal K; Murphy, William A; Park, Christine C; Veeder, Justin A; Tran, Lana; Beers, Jessica L; Jia, Wei; Stewart, Paul W; Brouwer, Kim L R

Membrane transporters in drug development and as determinants of precision medicine

膜转运蛋白在药物研发中的作用以及作为精准医疗的决定因素

Galetin, Aleksandra; Brouwer, Kim L R; Tweedie, Donald; Yoshida, Kenta; Sjöstedt, Noora; Aleksunes, Lauren; Chu, Xiaoyan; Evers, Raymond; Hafey, Michael J; Lai, Yurong; Matsson, Pär; Riselli, Andrew; Shen, Hong; Sparreboom, Alex; Varma, Manthena V S; Yang, Jia; Yang, Xinning; Yee, Sook Wah; Zamek-Gliszczynski, Maciej J; Zhang, Lei; Giacomini, Kathleen M

Effects of PFAS on human liver transporters: implications for health outcomes

全氟烷基物质对人类肝脏转运蛋白的影响:对健康结果的意义

Vujic, Ena; Ferguson, Stephen S; Brouwer, Kim L R

Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework

肝脏 OATP1B 区域分布:基于 PBPK 框架探讨利福平介导的药物相互作用的影响

Hartauer, Mattie; Murphy, William A; Brouwer, Kim L R; Southall, Roz; Neuhoff, Sibylle