日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects

Jeff 小鼠慢性中耳炎突变模型表现出功能获得和功能丧失效应

Oana Kubinyecz, Pratik P Vikhe, Thomas Purnell, Steve D M Brown, Hilda Tateossian

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

与肌萎缩侧索硬化症相关的SOD1突变体增强成年运动神经元的神经突生长和分支

Osking, Zachary; Ayers, Jacob I; Hildebrandt, Ryan; Skruber, Kristen; Brown, Hilda; Ryu, Daniel; Eukovich, Amanda R; Golde, Todd E; Borchelt, David R; Read, Tracy-Ann; Vitriol, Eric A

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

超氧化物歧化酶 1 中暴露于溶剂的赖氨酸残基的电荷丢失突变不会在培养细胞模型中诱导包涵体形成。

Crosby, Keith; Crown, Anthony M; Roberts, Brittany L; Brown, Hilda; Ayers, Jacob I; Borchelt, David R

Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

撤稿声明:过表达与肌萎缩侧索硬化症相关的蛋白Matrin 3的转基因小鼠会发展出严重的肌肉表型

Moloney, Christina; Rayaprolu, Sruti; Howard, John; Fromholt, Susan; Brown, Hilda; Collins, Matt; Cabrera, Mariela; Duffy, Colin; Siemienski, Zoe; Miller, Dave; Swanson, Maurice S; Notterpek, Lucia; Borchelt, David R; Lewis, Jada

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

显著提高SOD1突变小鼠脊髓运动神经元中αB-晶状体蛋白的水平并不能显著延缓瘫痪的发生或减弱突变蛋白的聚集。

Xu, Guilian; Fromholt, Susan; Ayers, Jacob I; Brown, Hilda; Siemienski, Zoe; Crosby, Keith W; Mayer, Christopher A; Janus, Christopher; Borchelt, David R

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

野生型 SOD1 增强双基因转基因小鼠中突变型 SOD1 毒性的直接和间接机制

Xu Guilian, Ayers Jacob I, Roberts Brittany L, Brown Hilda, Fromholt Susan, Green Cameron, Borchelt David R

Analysis of mutant SOD1 electrophoretic mobility by Blue Native gel electrophoresis; evidence for soluble multimeric assemblies

利用蓝胶电泳分析突变型SOD1的电泳迁移率;可溶性多聚体组装体的证据

Brown, Hilda H; Borchelt, David R

Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1.

野生型人类 SOD1 的特征限制了其与小鼠 G86R Sod1 错误折叠聚集体的相互作用

Qualls David A, Prudencio Mercedes, Roberts Brittany L T, Crosby Keith, Brown Hilda, Borchelt David R

Role of disulfide cross-linking of mutant SOD1 in the formation of inclusion-body-like structures

突变型SOD1二硫键交联在包涵体样结构形成中的作用

Roberts, Brittany L T; Patel, Kinaree; Brown, Hilda H; Borchelt, David R