日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

靶向 BCL-XL 的 BH3 模拟物对 RB1 缺失和复制压力的实体瘤有效

Varkaris Andreas, Wang Keshan, Nouri Mannan, Kozlova Nina, Schmidt Daniel R, Stavridi Anastasia, Arai Seiji, Ambrosio Nicholas, Poluben Larysa, Jimenez-Vacas Juan M, Westaby Daniel, Carmichael Juliet, Xie Fang, Figueiredo Ines, Buroni Lorenzo, Neeb Antje, Gurel Bora, Chevalier Nicholas, Brown Lisha, Voznesensky Olga, Chen Shao-Yong, Russo Joshua W, Yuan Xin, Juric Dejan, Beltran Himisha, De Bono Johann S, Vander Heiden Matthew G, Einstein David J, Muranen Taru, Corey Eva, Sharp Adam, Balk Steven P

Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.

表观遗传分析可识别内分泌耐药性标志物,并为转移性去势抵抗性前列腺癌提供治疗选择

Severson Tesa M, Minnee Emma, Zhu Yanyun, Schuurman Karianne, Nguyen Holly M, Brown Lisha G, Hakkola Sini, Menezes Renee, Gregoricchio Sebastian, Kim Yongsoo, Kneppers Jeroen, Linder Simon, Stelloo Suzan, Lieftink Cor, van der Heijden Michiel S, Nykter Matti, van der Noort Vincent, Sanders Joyce, Morris Ben, Jenster Guido, van Leenders Geert Jlh, Pomerantz Mark, Freedman Matthew L, Beijersbergen Roderick L, Urbanucci Alfonso, Wessels Lodewyk, Nelson Peter S, Corey Eva, Prekovic Stefan, Zwart Wilbert, Bergman Andries M

Small-molecule disruption of androgen receptor-dependent chromatin clusters

小分子对雄激素受体依赖性染色质簇的破坏作用

Kohrt, Sarah E; Novak, Emily J; Tapadar, Subhashish; Wu, Bocheng; Strope, Jonathan; Asante, Yaw; Kim, Hyunmin; Chang, Matthew S; Gurdak, Douglas; Khalil, Athar; Rood, Michael; Raftery, Eric; Stavreva, Diana; Nguyen, Holly M; Brown, Lisha G; Ramser, Maddy; Peer, Cody; Meyers, Warren M; Aboreden, Nicholas; Chakravortee, Maharshi; Sallari, Richard; Nelson, Peter S; Kelly, Kathleen K; Graham, Thomas G W; Darzacq, Xavier; Figg, William D; Oyelere, Adegboyega K; Corey, Eva; Adelaiye-Ogala, Remi; Gryder, Berkley E

Targeting the fibroblast growth factor pathway in molecular subtypes of castration-resistant prostate cancer

靶向去势抵抗性前列腺癌分子亚型中的成纤维细胞生长因子通路

Labrecque, Mark P; Brown, Lisha G; Coleman, Ilsa M; Nguyen, Holly M; Dalrymple, Susan; Brennen, W Nathaniel; Isaacs, John T; Li, Dapei; Lakely, Bryce; DeLucia, Diana C; Lee, John K; Schweizer, Michael T; Lin, Daniel W; Corey, Eva; Nelson, Peter S; Morrissey, Colm

Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients

增强子谱分析可识别内分泌耐药的表观遗传标记,并揭示转移性去势抵抗性前列腺癌患者的治疗选择。

Severson, Tesa M; Zhu, Yanyun; Prekovic, Stefan; Schuurman, Karianne; Nguyen, Holly M; Brown, Lisha G; Hakkola, Sini; Kim, Yongsoo; Kneppers, Jeroen; Linder, Simon; Stelloo, Suzan; Lieftink, Cor; van der Heijden, Michiel; Nykter, Matti; van der Noort, Vincent; Sanders, Joyce; Morris, Ben; Jenster, Guido; van Leenders, Geert Jlh; Pomerantz, Mark; Freedman, Matthew L; Beijersbergen, Roderick L; Urbanucci, Alfonso; Wessels, Lodewyk; Corey, Eva; Zwart, Wilbert; Bergman, Andries M

RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer

RNA剪接因子SRRM3和SRRM4可区分去势抵抗性神经内分泌前列腺癌的分子表型

Labrecque, Mark P; Brown, Lisha G; Coleman, Ilsa M; Lakely, Bryce; Brady, Nicholas J; Lee, John K; Nguyen, Holly M; Li, Dapei; Hanratty, Brian; Haffner, Michael C; Rickman, David S; True, Lawrence D; Lin, Daniel W; Lam, Hung-Ming; Alumkal, Joshi J; Corey, Eva; Nelson, Peter S; Morrissey, Colm

Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts

恩扎卢胺耐药性前列腺癌对超生理睾酮的持久反应与患者来源异种移植瘤中多方面的生长抑制和DNA损伤反应转录组程序受损有关

Lam, Hung-Ming; Nguyen, Holly M; Labrecque, Mark P; Brown, Lisha G; Coleman, Ilsa M; Gulati, Roman; Lakely, Bryce; Sondheim, Daniel; Chatterjee, Payel; Marck, Brett T; Matsumoto, Alvin M; Mostaghel, Elahe A; Schweizer, Michael T; Nelson, Peter S; Corey, Eva

Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

分子谱分析可对难治性转移性去势抵抗性前列腺癌的不同表型进行分层

Labrecque, Mark P; Coleman, Ilsa M; Brown, Lisha G; True, Lawrence D; Kollath, Lori; Lakely, Bryce; Nguyen, Holly M; Yang, Yu C; da Costa, Rui M Gil; Kaipainen, Arja; Coleman, Roger; Higano, Celestia S; Yu, Evan Y; Cheng, Heather H; Mostaghel, Elahe A; Montgomery, Bruce; Schweizer, Michael T; Hsieh, Andrew C; Lin, Daniel W; Corey, Eva; Nelson, Peter S; Morrissey, Colm

Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts

去势抵抗性前列腺癌患者来源异种移植模型中阿比特龙超敏感表型的特征分析

Lam, Hung-Ming; McMullin, Ryan; Nguyen, Holly M; Coleman, Ilsa; Gormley, Michael; Gulati, Roman; Brown, Lisha G; Holt, Sarah K; Li, Weimin; Ricci, Deborah S; Verstraeten, Karin; Thomas, Shibu; Mostaghel, Elahe A; Nelson, Peter S; Vessella, Robert L; Corey, Eva

SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer

SRRM4表达和REST活性丧失可能促进去势抵抗性前列腺癌中神经内分泌表型的出现

Zhang, Xiaotun; Coleman, Ilsa M; Brown, Lisha G; True, Lawrence D; Kollath, Lori; Lucas, Jared M; Lam, Hung-Ming; Dumpit, Ruth; Corey, Eva; Chéry, Lisly; Lakely, Bryce; Higano, Celestia S; Montgomery, Bruce; Roudier, Martine; Lange, Paul H; Nelson, Peter S; Vessella, Robert L; Morrissey, Colm