日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Crystal structures reveal phosphorylation-dependent disruption of the heat shock protein 70-CHIP interface: A compensatory G132N variant restores binding affinity

晶体结构揭示了磷酸化依赖性的热休克蛋白70-CHIP界面破坏：补偿性G132N变体恢复了结合亲和力

期刊:Cell Stress & Chaperones
影响因子:3.2
doi:10.1016/j.cstres.2026.100166
Stewart, Mariah; Paththamperuma, Chathura; McCann, Colleen; Cottingim, Kelsey; Zhang, Huaqun; DelVecchio, Rian; Peng, Ivy; Fennimore, Erica; Nix, Jay C; Saeed, Morcos N; George, Kathleen; Makaroff, Katherine; Colie, Meagan; Paulakonis, Ethan; Almeida, Michael F; Afolayan, Adeleye J; Brown, Nicholas G; Page, Richard C; Schisler, Jonathan C
信号转导
磷酸化
CHIP
发表日期：2026
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USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination.

USP37 通过 MCM 复合物去泛素化防止非计划的复制体卸载

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59770-7
Bolhuis Derek L, Fleifel Dalia, Bonacci Thomas, Wang Xianxi, Mouery Brandon L, Cook Jeanette Gowen, Brown Nicholas G, Emanuele Michael J
表观遗传
泛素化
发表日期：2025
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APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.

APC/C介导的核外组蛋白复合物泛素化，缺乏典型的降解信号

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-57384-7
Skrajna Aleksandra, Bodrug Tatyana, Martinez-Chacin Raquel C, Fisher Caleb B, Welsh Kaeli A, Simmons Holly C, Arteaga Eyla C, Simmons Jake M, Nasr Mohamed A, LaPak Kyle M, Nguyen Anh, Huynh Mai T, Fargo Isabel, Welfare Joshua G, Zhao Yani, Lawrence David S, Goldfarb Dennis, Brown Nicholas G, McGinty Robert K
信号转导
泛素化
发表日期：2025
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Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison.

通过旁系同源序列分析比较揭示 USP18 对 ISG15 的特异性机制

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110288
Bonacci Thomas, Bolhuis Derek L, Brown Nicholas G, Emanuele Michael J
SP1
发表日期：2025
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High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds

高通量蛋白质靶标定位可加速 ToxCast 和 PFAS 化合物的生物活性发现。

期刊:
影响因子:
doi:10.1101/2025.03.20.644436
Yang, Diwen; Wang, Xiaoyun; Liu, Jiabao; Gong, Yufeng; Nair, Pranav; Sun, Jianxian; Qian, Xing; Cui, Claire; Zeng, Hong; Dong, Aiping; Harding, Rachel J; Burgess-Brown, Nicola; Beyett, Tyler S; Song, Datong; Krause, Henry; Diamond, Miriam L; Bolhuis, Derek L; Brown, Nicholas G; Arrowsmith, Cheryl H; Edwards, Aled M; Halabelian, Levon; Peng, Hui
FAS
发表日期：2025
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Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering

磷酸化状态调控HSP70的结合：结构解析和补偿性蛋白工程

期刊:
影响因子:
doi:10.1101/2025.02.17.637997
Stewart, Mariah; Paththamperuma, Chathura; McCann, Colleen; Cottingim, Kelsey; Zhang, Huaqun; DelVecchio, Rian; Peng, Ivy; Fennimore, Erica; Nix, Jay C; Saeed, Morcos N; George, Kathleen; Makaroff, Katherine; Colie, Meagan; Paulakonis, Ethan; Almeida, Michael F; Afolayan, Adeleye J; Brown, Nicholas G; Page, Richard C; Schisler, Jonathan C
信号转导
SP7
HSP70
磷酸化
发表日期：2025
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Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

协同MAPT突变作为揭示tau蛋白致病机制修饰因子的平台

期刊:
影响因子:
doi:10.1101/2025.02.07.636933
Bryan, Miles R; Almeida, Michael; Pellegrino, Kyle; Opland, Carli; Paulakonis, Ethan; McGillion-Moore, Jake; Trzeciakiewicz, Hanna; King, Diamond; Tian, Xu; Tseng, Jui-Heng; Schisler, Jonathan; Brown, Nicholas G; Bahr, Ben; Cohen, Todd J
发表日期：2025
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Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

敌友难辨？E3泛素连接酶和去泛素化酶之间的相互调控

期刊:Biochemical Society Transactions
影响因子:4.3
doi:10.1042/BST20230454
Bolhuis, Derek L; Emanuele, Michael J; Brown, Nicholas G
信号转导
泛素化
表观遗传
发表日期：2024
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Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation

利用核磁共振监测TET依赖性甲基胞嘧啶双加氧酶的活性和调控

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.3c00619
Treadway, Colton J; Boyer, Joshua A; Yang, Shiyue; Yang, Hui; Liu, Mengxi; Li, Zhijun; Cheng, Meng; Marzluff, William F; Ye, Dan; Xiong, Yue; Baldwin, Albert S; Zhang, Qi; Brown, Nicholas G
信号转导
发表日期：2024
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Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase

利用一种具有广泛底物特异性的正交氨酰-tRNA合成酶，实现mRNA展示中的遗传密码扩展和肽大环化。

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.2c11294
Iskandar, Sabrina E; Pelton, Jarrett M; Wick, Elizaveta T; Bolhuis, Derek L; Baldwin, Albert S; Emanuele, Michael J; Brown, Nicholas G; Bowers, Albert A
发表日期：2023
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