日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

吗啡烷衍生的双重μ-κ阿片受体激动剂镇痛药的合成与药理学研究

Varga Balazs R, Uprety Rajendra, Paul Barnali, Knoll Alexis, Ramos-Gonzalez Nokomis, Appourchaux Kevin, Taylor Tori, Turgutalp Bengisu, Shinouchi Ryosuke, Eans Shainnel O, Williams Ashai K, Vasquez-Grinnell Steven G, Zaidi Saheem, Nazarova Antonina L, Varadi Andras, Le Rouzic Valerie, Brown Taylor G, Martinez Shani, Ansonoff Michael, Dardashti Rebecca Notis, Hunkele Amanda, Subrath Joan, Welch Matthew, Xu Jin, Rossi Grace C, Pintar John, Pasternak Gavril W, Katritch Vsevolod, McLaughlin Jay P, Pan Ying Xian, Majumdar Susruta

Absence of hippocampal pathology persists in the Q175DN mouse model of Huntington's disease despite elevated HTT aggregation.

尽管亨廷顿病 Q175DN 小鼠模型中 HTT 聚集增加,但海马病理学仍然缺失

Solem Melissa A, G Pelzel Ross, Rozema Nicholas B, Brown Taylor G, Reid Emma, Mansky Rachel H, Gomez-Pastor Rocio

Correction: SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex

更正:SNCA基因降低揭示了α-突触核蛋白的认知功能存在性别差异

Brown, Jennifer L; Hart, Damyan W; Boyle, Gabriel E; Brown, Taylor G; LaCroix, Michael; Baraibar, Andrés M; Pelzel, Ross; Kim, Minwoo; Sherman, Mathew A; Boes, Samuel; Sung, Michelle; Cole, Tracy; Lee, Michael K; Araque, Alfonso; Lesné, Sylvain E

Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT Aggregation

尽管mHTT聚集增加,Q175DN小鼠的海马储备能力仍增强

Solem, Melissa A; Pelzel, Ross; Rozema, Nicholas B; Brown, Taylor G; Reid, Emma; Mansky, Rachel H; Gomez-Pastor, R

Correction to: CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington's disease

更正:CK2α'和α-突触核蛋白致病性功能相互作用介导亨廷顿病中的突触功能紊乱

Yu, Dahyun; Zarate, Nicole; White, Angel; Coates, De'jah; Tsai, Wei; Nanclares, Carmen; Cuccu, Francesco; Yue, Johnny S; Brown, Taylor G; Mansky, Rachel H; Jiang, Kevin; Kim, Hyuck; Nichols-Meade, Tessa; Larson, Sarah N; Gundry, Katherine; Zhang, Ying; Tomas-Zapico, Cristina; Lucas, Jose J; Benneyworth, Michael; Öz, Gülin; Cvetanovic, Marija; Araque, Alfonso; Gomez-Pastor, Rocio

Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats

男性海洛因滥用者和海洛因自我给药雄性大鼠内侧前额皮质中μ阿片受体基因OPRM1选择性剪接变体mRNA的表达失调

Brown, Taylor G; Xu, Jin; Hurd, Yasmin L; Pan, Ying-Xian

Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine

μ阿片受体C端选择性剪接影响吗啡的多种作用

Xu, Jin; Lu, Zhigang; Narayan, Ankita; Le Rouzic, Valerie P; Xu, Mingming; Hunkele, Amanda; Brown, Taylor G; Hoefer, William F; Rossi, Grace C; Rice, Richard C; Martínez-Rivera, Arlene; Rajadhyaksha, Anjali M; Cartegni, Luca; Bassoni, Daniel L; Pasternak, Gavril W; Pan, Ying-Xian