日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.

发现并表征了具有强大髓系激活和抗肿瘤活性的首创 LIV1-TLR7/8 免疫调节偶联物

Yamazoe Sayumi, Poudel Yam, Sega Emanuela, Mukhopadhyay Anandaroop, Ramakrishnan Radha, Ukairo Okechukwu, Liu Scot, Akter Rahima, Sadanala Keerthi, Que Kathryn, Cheng Qinqin, Kotapati Srikanth, Deshpande Madhura, Cox Matthew, Chourey Shishir, Gupta Anuradha, Kempson James, Pabbisetty Kumar, Kaspady Mahammed, Bhattasali Debabrata, Yip Shiuhang, Wu Dauh-Rurng, Pookot Deepa, Li Yvonne, Kozhich Alexander, Drexler Dieter, Carl Stephen, Deyanova Ekaterina, Smith Michael, Chan Henry, West Sean, Diong S J, Chang Aram, Florin Lore, Mathur Arvind, Strop Pavel, Zapf Christoph W, Law Deborah, Wilson Nicholas, Broz Miranda, Chekler Eugene P

Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells

将TLR7激动剂靶向递送至肿瘤微环境可通过激活肿瘤驻留髓系细胞增强肿瘤免疫力

Sega, Emanuela; Kotapati, Srikanth; Poudel, Yam B; Cheng, Qinqin; Sadanala, Keerthi; Schneider, Bridget; Chekler, Eugene P; Rao, Chetana; Gangwar, Sanjeev; Sproul, Tim; Law, Deborah; Broz, Miranda; Strop, Pavel; Yamazoe, Sayumi

Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein.

应用药代动力学/药效学模型连接小鼠抗肿瘤疗效和猴子毒理学数据,以确定白细胞介素-10 Fc融合蛋白的治疗指数

Yang Zheng, Loy James, Poirson Brian, Dai Yanshan, Rajendran Surendran, Xu Shihua, Spires Vanessa, Gururajan Murali, Lin Zheng, Arbanas Jaren, Carl Stephen, Pace Samantha, Wang Yun, Mehl John, Vasudevan Krishna, Spires Thomas, Novosiadly Ruslan, Coker Shodeinde, Perez Raymond, Covello Kelly, Morin Paul, Graziano Robert, Broz Miranda, Lehman-McKeeman Lois

The emerging understanding of myeloid cells as partners and targets in tumor rejection

人们逐渐认识到髓系细胞既是肿瘤排斥反应的伙伴,也是其靶点。

Broz, Miranda L; Krummel, Matthew F

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity

对肿瘤髓系细胞进行解剖,揭示了对T细胞免疫至关重要的罕见激活性抗原呈递细胞。

Broz, Miranda L; Binnewies, Mikhail; Boldajipour, Bijan; Nelson, Amanda E; Pollack, Joshua L; Erle, David J; Barczak, Andrea; Rosenblum, Michael D; Daud, Adil; Barber, Diane L; Amigorena, Sebastian; Van't Veer, Laura J; Sperling, Anne I; Wolf, Denise M; Krummel, Matthew F

Arabidopsis tetraspanins are confined to discrete expression domains and cell types in reproductive tissues and form homo- and heterodimers when expressed in yeast

拟南芥四跨膜蛋白在生殖组织中局限于特定的表达区域和细胞类型,并且在酵母中表达时形成同源二聚体和异源二聚体。

Boavida, Leonor C; Qin, Peng; Broz, Miranda; Becker, Jörg D; McCormick, Sheila

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer

对既往存档样本和前瞻性收集的样本进行深入调查,未发现前列腺癌中存在XMRV感染的证据。

Lee, Deanna; Das Gupta, Jaydip; Gaughan, Christina; Steffen, Imke; Tang, Ning; Luk, Ka-Cheung; Qiu, Xiaoxing; Urisman, Anatoly; Fischer, Nicole; Molinaro, Ross; Broz, Miranda; Schochetman, Gerald; Klein, Eric A; Ganem, Don; Derisi, Joseph L; Simmons, Graham; Hackett, John Jr; Silverman, Robert H; Chiu, Charles Y