日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IGM-7354, an Immunocytokine with IL15 Fused to an Anti-PD-L1 IgM, Induces NK and CD8+ T cell-Mediated Cytotoxicity of PD-L1-Positive Tumor Cells

IGM-7354 是一种免疫细胞因子,其由 IL15 与抗 PD-L1 IgM 融合而成,可诱导 NK 细胞和 CD8+ T 细胞介导的对 PD-L1 阳性肿瘤细胞的细胞毒性。

Mélanie Desbois ,Thierry Giffon ,Poonam Yakkundi ,Carolyn R Denson ,Keerthana Sekar ,Kevin C Hart ,Daniel Santos ,Susan E Calhoun ,Kathryn Logronio ,Sivani Pandey ,Dean Ng ,Avneesh K Saini ,Beatrice T Wang ,Bruce A Keyt ,Angus M Sinclair ,Maya F Kotturi

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

ACE2十聚体病毒陷阱作为当前和未来SARS-CoV的持久干预方案

Hailong Guo,Bomsoo Cho,Paul R Hinton,Sijia He,Yongjun Yu,Ashwin Kumar Ramesh,Jwala Priyadarsini Sivaccumar,Zhiqiang Ku,Kristen Campo,Sarah Holland,Sameer Sachdeva,Christopher Mensch,Mohamed Dawod,Annalis Whitaker,Philip Eisenhauer,Allison Falcone,Rebekah Honce,Jason W Botten,Stephen F Carroll,Bruce A Keyt,Andrew W Womack,William R Strohl,Kai Xu,Ningyan Zhang,Zhiqiang An,Sha Ha,John W Shiver,Tong-Ming Fu

Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants

鼻腔注射 IgM 可广泛预防 SARS-CoV-2 变体

Zhiqiang Ku #, Xuping Xie #, Paul R Hinton #, Xinli Liu #, Xiaohua Ye, Antonio E Muruato, Dean C Ng, Sujit Biswas, Jing Zou, Yang Liu, Deepal Pandya, Vineet D Menachery, Sachi Rahman, Yu-An Cao, Hui Deng, Wei Xiong, Kevin B Carlin, Junquan Liu, Hang Su, Elizabeth J Haanes, Bruce A Keyt, Ningyan Zhan

Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199

多聚抗 DR5 IgM 激动剂抗体 IGM-8444 是癌细胞凋亡的强效诱导剂,并与化疗和 BCL-2 抑制剂 ABT-199 产生协同作用

Beatrice T Wang, Tasnim Kothambawala #, Ling Wang #, Thomas J Matthew #, Susan E Calhoun, Avneesh K Saini, Maya F Kotturi, Genevive Hernandez, Eric W Humke, Marvin S Peterson, Angus M Sinclair, Bruce A Keyt

Antibody discovery via multiplexed single cell characterization

通过多路复用单细胞表征发现抗体

William D Harriman, Ellen J Collarini, Gizette V Sperinde, Magnus Strandh, Marjan M Fatholahi, April Dutta, Yunji Lee, Shelley E Mettler, Bruce A Keyt, Stote L Ellsworth, Lawrence M Kauvar