日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

苯并恶唑衍生物可增强前颗粒蛋白的表达,并逆转由 GRN 单倍体不足引起的溶酶体蛋白质组异常

Rachel Tesla #, Charlotte Guhl #, Gordon C Werthmann #, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M Fass, Zachary Rosenthal, Stephen J Haggarty, Noelle S Williams, Bruce A Posner, Joseph M Ready, Joachim Herz

Targeting ESR1 mutation-induced transcriptional addiction in breast cancer with BET inhibition

通过 BET 抑制靶向 ESR1 突变诱导的乳腺癌转录成瘾

Sm N Udden, Qian Wang, Sunil Kumar, Venkat S Malladi, Shwu-Yuan Wu, Shuguang Wei, Bruce A Posner, Sophie Geboers, Noelle S Williams, Yulun Liu, Jayesh K Sharma, Ram S Mani, Srinivas Malladi, Karla Parra, Mia Hofstad, Ganesh V Raj, Jose M Larios, Reshma Jagsi, Max S Wicha, Ben Ho Park, Gaorav P Gupta

Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones

使用独特的 ecDHFR 药理伴侣同时控制内源性和用户定义的遗传途径

Prerana Ramadurgum, DaNae R Woodard, Steffi Daniel, Hui Peng, Prema L Mallipeddi, Hanspeter Niederstrasser, Melina Mihelakis, Viet Q Chau, Peter M Douglas, Bruce A Posner, John D Hulleman

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia

自噬蛋白Beclin 1与Na+,K+-ATPase在饥饿、运动和缺血期间的相互作用

Álvaro F Fernández ,Yang Liu ,Vanessa Ginet ,Mingjun Shi ,Jihoon Nah ,Zhongju Zou ,Anwu Zhou ,Bruce A Posner ,Guanghua Xiao ,Marion Tanguy ,Valérie Paradis ,Junichi Sadoshima ,Pierre-Emmanuel Rautou ,Julien Puyal ,Ming Chang Hu ,Beth Levine

Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics

胰腺导管腺癌 (PDA) 化疗药物的协同细胞和体内筛选

Somayeh Layeghi-Ghalehsoukhteh, Shreoshi Pal Choudhuri, Ozhan Ocal, Yalda Zolghadri, Victor Pashkov, Hanspeter Niederstrasser, Bruce A Posner, Havish S Kantheti, Ana C Azevedo-Pouly, Huocong Huang, Luc Girard, Raymond J MacDonald, Rolf A Brekken, Thomas M Wilkie1

HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress

HORMAD1 是肺腺癌的负面预后指标,并具有抗氧化和基因毒性应激的能力

Brandt A Nichols, Nathaniel W Oswald, Elizabeth A McMillan, Kathleen McGlynn, Jingsheng Yan, Min S Kim, Janapriya Saha, Prema L Mallipeddi, Sydnie A LaDuke, Pamela A Villalobos, Jaime Rodriguez-Canales, Ignacio I Wistuba, Bruce A Posner, Anthony J Davis, John D Minna, John B MacMillan, Angelique W W

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding

通过高通量筛选鉴定通过破坏 Beclin 1/Bcl-2 结合发挥作用的自噬诱导剂

Wei-Chung Chiang, Yongjie Wei, Yi-Chun Kuo, Shuguang Wei, Anwu Zhou, Zhongju Zou, Jenna Yehl, Matthew J Ranaghan, Adam Skepner, Joshua A Bittker, Jose R Perez, Bruce A Posner, Beth Levine

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

SMARCA4 失活突变可增加非小细胞肺癌对 Aurora 激酶 A 抑制剂 VX-680 的敏感性

Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A Brekken, Bruce A Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A Wheeler, John D Minna, Michael A White, Adi F Gazdar, Michael G Roth

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

小分子 TFEB 通路激动剂可改善小鼠代谢综合征并延长秀丽隐杆线虫寿命

Chensu Wang, Hanspeter Niederstrasser, Peter M Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W Oswald, Anwu Zhou, Elizabeth A McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A Brekken, Bruce A Posner, John B MacMillan, Jinming Gao, Michael A

TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer

TBK1 为肺癌中激活的 AKT/mTOR 通路提供环境选择性支持

Jonathan M Cooper, Yi-Hung Ou, Elizabeth A McMillan, Rachel M Vaden, Aubhishek Zaman, Brian O Bodemann, Gurbani Makkar, Bruce A Posner, Michael A White