日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors

靶向IDR的化合物通过破坏磷酸化BRD4与DNA损伤反应因子的结合来抑制HPV基因组复制。

Shwu-Yuan Wu ,Hsien-Tsung Lai ,N Sanjib Banerjee ,Zonghui Ma ,Juan F Santana ,Shuguang Wei ,Xisheng Liu ,Meirong Zhang ,Jian Zhan ,Haiying Chen ,Bruce Posner ,Yadong Chen ,David H Price ,Louise T Chow ,Jia Zhou ,Cheng-Ming Chiang

Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening

通过高通量筛选鉴定一类 WNK 异构体特异性抑制剂

Julita Chlebowicz, Radha Akella, John M Humphreys, Haixia He, Ashari R Kannangara, Shuguang Wei, Bruce Posner, Elizabeth J Goldsmith

A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins

多管齐下的方法证实,β-微管蛋白的共价修饰是苯甲酰胺类抗癌毒素的作用机制

Juan Manuel Povedano,Rameshu Rallabandi,Xin Bai,Xuecheng Ye,Joel Liou,Hong Chen,Jiwoong Kim,Yang Xie,Bruce Posner,Luke Rice,Jef K De Brabander,David G McFadden

Chemical intervention of influenza virus mRNA nuclear export

流感病毒 mRNA 核输出的化学干预

Matthew Esparza, Amir Mor, Hanspeter Niederstrasser, Kris White, Alexander White, Ke Zhang, Shengyan Gao, Juan Wang, Jue Liang, Sei Sho, Ramanavelan Sakthivel, Adwait A Sathe, Chao Xing, Raquel Muñoz-Moreno, Jerry W Shay, Adolfo García-Sastre, Joseph Ready, Bruce Posner, Beatriz M A Fontoura

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening

前列腺素脱氢酶是成功诱导宫颈成熟的目标

Annavarapu Hari Kishore, Hanquan Liang, Mohammed Kanchwala, Chao Xing, Thota Ganesh, Yucel Akgul, Bruce Posner, Joseph M Ready, Sanford D Markowitz, Ruth Ann Word

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

结肠直肠癌中突变型腺瘤性息肉病 (APC) 的选择性靶向治疗

Lu Zhang, Panayotis C Theodoropoulos, Ugur Eskiocak, Wentian Wang, Young-Ah Moon, Bruce Posner, Noelle S Williams, Woodring E Wright, Sang Bum Kim, Deepak Nijhawan, Jef K De Brabander, Jerry W Shay

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

高通量同时筛选和反筛选鉴定出高三尖杉酯碱为合成致死物,导致肾细胞癌出现冯·希佩尔-林道基因缺失

Nicholas C Wolff, Andrea Pavía-Jiménez, Vanina T Tcheuyap, Shane Alexander, Mridula Vishwanath, Alana Christie, Xian-Jin Xie, Noelle S Williams, Payal Kapur, Bruce Posner, Renée M McKay, James Brugarolas

Identification of DNMT1 selective antagonists using a novel scintillation proximity assay

使用新型闪烁近接分析法鉴定 DNMT1 选择性拮抗剂

Jessica A Kilgore, Xinlin Du, Lisa Melito, Shuguang Wei, Changguang Wang, Hang Gyeong Chin, Bruce Posner, Sriharsa Pradhan, Joseph M Ready, Noelle S Williams

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor

生长素释放肽受体的螺环哌啶-氮杂环丁烷逆激动剂的鉴定

Daniel W Kung, Steven B Coffey, Ryan M Jones, Shawn Cabral, Wenhua Jiao, Michael Fichtner, Philip A Carpino, Colin R Rose, Richard F Hank, Michael G Lopaze, Roger Swartz, Hou Tommy Chen, Zachary Hendsch, Bruce Posner, Christopher F Wielis, Brian Manning, Jeffrey Dubins, Ingrid A Stock, Sam Varma, Ma