日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells

ADAM17功能阻断抗体增强IL-15介导的NK细胞活化和增殖,该过程涉及CD16A、CD137和辅助细胞。

Anders W Matson ,Rob Hullsiek ,Kate J Dixon ,Sam Wang ,Anders J Lindstedt ,Ryan R Friess ,Shee Kwan Phung ,Tanya S Freedman ,Martin Felices ,Emily N Truckenbrod ,Jianming Wu ,Jeffrey S Miller ,Bruce Walcheck

iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma

iPSC 衍生的 NK 细胞表达高亲和力 IgG Fc 受体融合 CD64/16A,介导针对淋巴瘤的灵活、多肿瘤抗原靶向治疗

Kate J Dixon, Kristin M Snyder, Melissa Khaw, Robert Hullsiek, Zachary B Davis, Anders W Matson, Soheila Shirinbak, Bryan Hancock, Ryan Bjordahl, Martin Hosking, Jeffrey S Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck

iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting

表达 FcγR 融合 CD64/16A 的 iPSC 衍生自然杀伤细胞可配备抗体,实现多肿瘤抗原靶向

Kristin M Snyder, Kate J Dixon, Zachary Davis, Martin Hosking, Geoffrey Hart, Melissa Khaw, Anders Matson, Ryan Bjordahl, Bryan Hancock, Soheila Shirinbak, Jeffrey S Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck

Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production

利用 CRISPR/Cas9 技术敲除扩增的原代人 NK 细胞中的 SYK 激酶可增强细胞毒性和细胞因子产生。

James D Dahlvang ,Jenna K Dick ,Jules A Sangala ,Philippa R Kennedy ,Emily J Pomeroy ,Kristin M Snyder ,Juliette M Moushon ,Claire E Thefaine ,Jianming Wu ,Sara E Hamilton ,Martin Felices ,Jeffrey S Miller ,Bruce Walcheck ,Beau R Webber ,Branden S Moriarity ,Geoffrey T Hart

Detection of Antibody-Dependent Cell-Mediated Cytotoxicity-Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization

NK-92-CD16A 细胞外化 CD107a 检测抗体依赖性细胞介导的细胞毒性支持抗体:抗体无岩藻糖基化的识别和检测优化

Judith Cruz Amaya, Bruce Walcheck, Julie Smith-Gagen, Vincent C Lombardi, Dorothy Hudig

Dual antigen-targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia

双抗原靶向的现成 NK 细胞表现出持久反应并防止淋巴瘤和白血病中的抗原逃逸

Frank Cichocki, Jodie P Goodridge, Ryan Bjordahl, Sajid Mahmood, Zachary B Davis, Svetlana Gaidarova, Ramzey Abujarour, Brian Groff, Alec Witty, Hongbo Wang, Katie Tuininga, Behiye Kodal, Martin Felices, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T Lee, Bruce Walcheck, Bahram Valamehr, Jeffrey

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

四重基因工程自然杀伤细胞可实现多抗原靶向,对多发性骨髓瘤具有持久的抗肿瘤活性

Frank Cichocki #, Ryan Bjordahl #, Jodie P Goodridge, Sajid Mahmood, Svetlana Gaidarova, Ramzey Abujarour, Zachary B Davis, Aimee Merino, Katie Tuininga, Hongbo Wang, Akhilesh Kumar, Brian Groff, Alec Witty, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T Lee, Karl-Johan Malmberg, Bruce Walcheck, 

Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells

检测犬白细胞IgG Fc受体CD16A和CD64的表达及其在工程化NK细胞中的ADCC活性

Robert Hullsiek,Yunfang Li,Kristin M Snyder,Sam Wang,Da Di,Antonella Borgatti,Chae Lee,Peter F Moore,Cong Zhu,Chiara Fattori,Jaime F Modiano,Jianming Wu,Bruce Walcheck

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

利用适应性NK细胞的特性生成iPSC衍生NK细胞以增强免疫治疗

Karrune V Woan ,Hansol Kim ,Ryan Bjordahl ,Zachary B Davis ,Svetlana Gaidarova ,John Goulding ,Brian Hancock ,Sajid Mahmood ,Ramzey Abujarour ,Hongbo Wang ,Katie Tuininga ,Bin Zhang ,Cheng-Ying Wu ,Behiye Kodal ,Melissa Khaw ,Laura Bendzick ,Paul Rogers ,Moyar Qing Ge ,Greg Bonello ,Miguel Meza ,Martin Felices ,Janel Huffman ,Thomas Dailey ,Tom T Lee ,Bruce Walcheck ,Karl J Malmberg ,Bruce R Blazar ,Yenan T Bryceson ,Bahram Valamehr ,Jeffrey S Miller ,Frank Cichocki

Simultaneous Engagement of Tumor and Stroma Targeting Antibodies by Engineered NK-92 Cells Expressing CD64 Controls Prostate Cancer Growth

经基因工程改造的表达CD64的NK-92细胞同时激活肿瘤和基质靶向抗体,从而控制前列腺癌的生长。

Hallie M Hintz # ,Kristin M Snyder # ,Jianming Wu ,Robert Hullsiek ,James D Dahlvang ,Geoffrey T Hart ,Bruce Walcheck ,Aaron M LeBeau