日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

药物 HIF-2α 拮抗剂对缺氧通气控制的显著和快速作用

Xiaotong Cheng, Maria Prange-Barczynska, James W Fielding, Minghao Zhang, Alana L Burrell, Joanna Dcc Lima, Luise Eckardt, Isobel LA Argles, Christopher W Pugh, Keith J Buckler, Peter A Robbins, Emma J Hodson, Richard K Bruick, Lucy M Collinson, Fraydoon Rastinejad, Tammie Bishop, Peter J Ratcliffe

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin α interactions

输入蛋白α的结构、ChREBP的核定位肽以及ChREBP-输入蛋白α相互作用的小分子化合物抑制剂

Jung, Hunmin; Takeshima, Tomomi; Nakagawa, Tsutomu; MacMillan, Karen S; Wynn, R Max; Wang, Hanzhi; Sakiyama, Haruhiko; Wei, Shuguang; Li, Yang; Bruick, Richard K; Posner, Bruce A; De Brabander, Jef K; Uyeda, Kosaku

Modulation of HIF-2α PAS-B domain contributes to physiological responses

HIF-2α PAS-B 结构域的调控有助于生理反应

Feng, Zhihui; Zou, Xuan; Chen, Yaomin; Wang, Hanzhi; Duan, Yingli; Bruick, Richard K

Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD

缺氧诱导因子-2α在胃食管反流病(GORD)的食管炎中发挥作用。

Huo, Xiaofang; Agoston, Agoston T; Dunbar, Kerry B; Cipher, Daisha J; Zhang, Xi; Yu, Chunhua; Cheng, Edaire; Zhang, Qiuyang; Pham, Thai H; Tambar, Uttam K; Bruick, Richard K; Wang, David H; Odze, Robert D; Spechler, Stuart J; Souza, Rhonda F

Targeting renal cell carcinoma with a HIF-2 antagonist

使用 HIF-2 拮抗剂治疗肾细胞癌

Wenfang Chen, Haley Hill, Alana Christie, Min Soo Kim, Eboni Holloman, Andrea Pavia-Jimenez, Farrah Homayoun, Yuanqing Ma, Nirav Patel, Paul Yell, Guiyang Hao, Qurratulain Yousuf, Allison Joyce, Ivan Pedrosa, Heather Geiger, He Zhang, Jenny Chang, Kevin H Gardner, Richard K Bruick, Catherine Reeves,

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

HIF-2α拮抗剂在临床前肾癌模型中的靶向疗效

Cho, Hyejin; Du, Xinlin; Rizzi, James P; Liberzon, Ella; Chakraborty, Abhishek A; Gao, Wenhua; Carvo, Ingrid; Signoretti, Sabina; Bruick, Richard K; Josey, John A; Wallace, Eli M; Kaelin, William G

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

一种小分子调节 Jumonji 组蛋白去甲基化酶活性并选择性抑制癌症生长

Lei Wang, Jianjun Chang, Diana Varghese, Michael Dellinger, Subodh Kumar, Anne M Best, Julio Ruiz, Richard Bruick, Samuel Peña-Llopis, Junjie Xu, David J Babinski, Doug E Frantz, Rolf A Brekken, Amy M Quinn, Anton Simeonov, Johnny Easmon, Elisabeth D Martinez

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

利用小分子对缺氧诱导因子-2进行变构抑制

Thomas H Scheuermann, Qiming Li, He-Wen Ma, Jason Key, Lei Zhang, Rui Chen, Joseph A Garcia, Jacinth Naidoo, Jamie Longgood, Doug E Frantz, Uttam K Tambar, Kevin H Gardner, Richard K Bruick

Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules

调节 ARNT/TACC3 轴:利用小分子操纵蛋白质/蛋白质相互作用的多种方法

Yirui Guo, Carrie L Partch, Jason Key, Paul B Card, Victor Pashkov, Anjana Patel, Richard K Bruick, Heiko Wurdak, Kevin H Gardner

Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms

F-box 和富含亮氨酸重复蛋白 5 (FBXL5) 内的类血红蛋白结构域通过不同的机制传达细胞铁和氧气的可用性

Srinivas Chollangi, Joel W Thompson, Julio C Ruiz, Kevin H Gardner, Richard K Bruick