日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity

研究呋喃脒结构修饰对DNA小沟结合及抗原生动物活性的影响

期刊:European Journal of Medicinal Chemistry
影响因子:5.9
doi:10.1016/j.ejmech.2023.115287
Farahat, Abdelbasset A; Kumar, Arvind; Wenzler, Tanja; Brun, Reto; Paul, Ananya; Guo, Pu; Wilson, W David; Boykin, David W
发表日期：2023
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Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

重新定位二氨基噻唑系列化合物，证实其靶向细胞周期蛋白依赖性激酶CRK12，可用于治疗非洲动物锥虫病

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c02104
Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H
信号转导
细胞生物学
发表日期：2022
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Michellamines A(6) and A(7), and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells

从刚果藤本植物 Ancistrocladus liana 中分离得到的 Michellamines A(6) 和 A(7) 以及其他单体和二聚体萘基异喹啉生物碱及其对胰腺癌细胞的抗增殖活性

期刊:RSC Advances
影响因子:4.6
doi:10.1039/c8ra00363g
Lombe, Blaise Kimbadi; Feineis, Doris; Mudogo, Virima; Brun, Reto; Awale, Suresh; Bringmann, Gerhard
肿瘤免疫
细胞生物学
胰腺癌
肿瘤
发表日期：2018
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Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity

来自灰叶菊（Vernonia cinerascens Sch. Bip.）的倍半萜内酯及其体外抗锥虫活性

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules23020248
Kimani, Njogu M; Matasyoh, Josphat C; Kaiser, Marcel; Brun, Reto; Schmidt, Thomas J
发表日期：2018
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Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

鉴定出一种 4-氟苄基 L-缬氨酸酰胺苯并硼氧杂环戊烯 (AN11736) 作为治疗动物非洲锥虫病 (AAT) 的潜在候选药物

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2017.11.028
Akama, Tsutomu; Zhang, Yong-Kang; Freund, Yvonne R; Berry, Pamela; Lee, Joanne; Easom, Eric E; Jacobs, Robert T; Plattner, Jacob J; Witty, Michael J; Peter, Rosemary; Rowan, Tim G; Gillingwater, Kirsten; Brun, Reto; Nare, Bakela; Mercer, Luke; Xu, Musheng; Wang, Jiangong; Liang, Hao
发表日期：2018
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Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm

来自毛叶菝葜（Vernonia lasiopus O. Hoffm）的抗锥虫埃莱曼内酯倍半萜内酯

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules22040597
Kimani, Njogu M; Matasyoh, Josphat C; Kaiser, Marcel; Brun, Reto; Schmidt, Thomas J
发表日期：2017
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Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense

从非洲霍拉赫纳（Holarrhena africana）中提取的甾体生物碱对罗得西亚锥虫（Trypanosoma brucei rhodesiense）具有强效活性。

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules22071129
Nnadi, Charles Okeke; Nwodo, Ngozi Justina; Kaiser, Marcel; Brun, Reto; Schmidt, Thomas J
发表日期：2017
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In Vitro, Ex Vivo, and In Vivo Activities of Diamidines against Trypanosoma congolense and Trypanosoma vivax.

二脒类化合物对刚果锥虫和维氏锥虫的体外、离体和体内活性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02356-16
Gillingwater Kirsten, Kunz Christina, Braghiroli Christiane, Boykin David W, Tidwell Richard R, Brun Reto
发表日期：2017
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Antiplasmodial Ealapasamines A-C,'Mixed' Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis

来自中非藤本植物 Ancistrocladus ealaensis 的抗疟原虫 Ealapasamines AC，“混合”萘基异喹啉二聚体

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-017-05719-w
Tshitenge, Dieudonné Tshitenge; Feineis, Doris; Mudogo, Virima; Kaiser, Marcel; Brun, Reto; Bringmann, Gerhard
发表日期：2017
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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

新型抗疟化合物ACT-451840的特性研究：活性和剂量-疗效模型的临床前评估

期刊:PLoS Medicine
影响因子:9.9
doi:10.1371/journal.pmed.1002138
Le Bihan, Amélie; de Kanter, Ruben; Angulo-Barturen, Iñigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Burrows, Jeremy; Dechering, Koen J; Delves, Michael; Ewerling, Sonja; Ferrer, Santiago; Fischli, Christoph; Gamo-Benito, Francisco Javier; Gnädig, Nina F; Heidmann, Bibia; Jiménez-Díaz, María Belén; Leroy, Didier; Martínez, Maria Santos; Meyer, Solange; Moehrle, Joerg J; Ng, Caroline L; Noviyanti, Rintis; Ruecker, Andrea; Sanz, Laura María; Sauerwein, Robert W; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N; Weller, Thomas; Fischli, Walter; Fidock, David A; Clozel, Martine; Wittlin, Sergio
发表日期：2016
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