日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multimodal bHLH-PAS DNA binding controls specificity and drives obesity

多模式 bHLH-PAS DNA 结合控制特异性并驱动肥胖

Bersten, David C; McDougal, Daniel P; Sullivan, Adrienne E; Gerassimou, Alexis; Breen, James; Fitzsimmons, Rebecca L; Muscat, George E O; Pederson, Stephen; Bruning, John B; Fan, Chen-Ming; Thomas, Paul Q; Russell, Darryl L; Peet, Daniel J; Whitelaw, Murray L

Structural basis for substrate-dependent allostery in oxygen activation by a cytochrome P450 enzyme revealed by analysis at different temperatures

通过不同温度下的分析揭示了细胞色素P450酶氧活化过程中底物依赖性变构的结构基础

Podgorski, Matthew N; McDougal, Daniel P; Campbell, Eleanor C; Bruning, John B; Bell, Stephen G

A ternary switch model governing ERα ligand binding domain conformation

控制ERα配体结合域构象的三元开关模型

McDougal, Daniel P; Pederick, Jordan L; Novick, Scott J; Jovcevski, Blagojce; Warrender, Annmaree K; Pascal, Bruce D; Griffin, Patrick R; Bruning, John B

Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications.

非共价 PPARγ 反向激动作用的结构决定因素及其治疗意义。

Kuo Kuang-Ting, Bdiri Bilel, He Yuanjun, Garcia-Ordonez Ruben D, McDougal Daniel P, Ruiz Claudia, Chang Mi Ra, Cameron Michael D, Bruning John B, Kamenecka Theodore M, Griffin Patrick R

Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.

蛋白质二硫键异构酶调节雄激素受体稳定性,促进前列腺癌细胞生长和存活。

Xie Jianling, Shen Kaikai, Liang Wenken, Kuang Zijian, Shrestha Raj K, Hanson Adrienne R, Townley Scott L, He Meiling, Yu Sishu, Zhou Peiwen, Zhu Liangzhen, Gong Zhiwen, Ao Xiang, Rao Sushma R, Zhang Qing, Chen Kaijie, Wei Jinfen, Marri Shashikanth, Snel Marten F, Irani Swati, Chen Liye, Wang Ling, McDougal Daniel P, Bruning John B, Ou Minglin, Wang Shaobo, Proud Christopher G, Du Hongli, Butler Lisa M, Selth Luke A

Evolutionary insights into the selectivity of sterol oxidising cytochrome P450 enzymes based on ancestral sequence reconstruction

基于祖先序列重建的甾醇氧化细胞色素P450酶选择性的进化见解

Doherty, Daniel Z; De Voss, James J; Bruning, John B; Bell, Stephen G

Functional and structural characterization of Staphylococcus aureus N-acetylglucosamine 1-phosphate uridyltransferase (GlmU) reveals a redox-sensitive acetyltransferase activity.

金黄色葡萄球菌 N-乙酰氨基葡萄糖 1-磷酸尿苷酰转移酶 (GlmU) 的功能和结构表征揭示了氧化还原敏感的乙酰转移酶活性

Pederick Jordan L, Kumar Akhil, Pukala Tara L, Bruning John B

Antigenic structural analysis of bat and human norovirus protruding (P) domains

蝙蝠和人类诺如病毒突出(P)结构域的抗原结构分析

Holroyd, Dayna L; Kumar, Akhil; Vasquez, Eduardo; Masic, Veronika; von Itzstein, Mark; Bruning, John B; Hansman, Grant S

Identification of Cysteine Metabolism Regulator (CymR)-Derived Pentapeptides as Nanomolar Inhibitors of Staphylococcus aureus O-Acetyl-l-serine Sulfhydrylase (CysK)

鉴定半胱氨酸代谢调节因子(CymR)衍生的五肽为金黄色葡萄球菌O-乙酰-L-丝氨酸硫氢酶(CysK)的纳摩尔抑制剂

Pederick, Jordan L; Vandborg, Bethiney C; George, Amir; Bovermann, Hannah; Boyd, Jeffrey M; Freundlich, Joel S; Bruning, John B

Structural constraints prevent a bat norovirus from binding to histo-blood group antigen co-factors

结构限制阻止蝙蝠诺如病毒与组织血型抗原辅助因子结合。

Holroyd, Dayna L; Bruning, John B; von Itzstein, Mark; Hansman, Grant S