Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter

雌激素和孕酮通过 c-Jun/c-Fos/雌激素受体（孕酮受体）复合物组装到远端调控元件上，诱导转录去抑制，并将细胞周期蛋白 D1 募集到其自身的基因启动子上，从而促进 G1 期间 CCND1 基因的持续激活