日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

大环分子胶用于 14-3-3/ChREBP 相互作用：亲和力和协同性呈反比关系

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202521678
Pennings, Marloes A M; van den Bosch, Merel A W; Oberheide, Ansgar; Verhoef, Carlo J A; Ottmann, Christian; Markvoort, Albert J; Miley, Galen P; Brunsveld, Luc
EBP
ChREBP
发表日期：2026
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Automated navigation of condensate phase behavior with active machine learning

利用主动机器学习实现冷凝相行为的自动导航

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-64617-2
Leurs, Yannick H A; van den Hout, Willem; Gardin, Andrea; van Dongen, Joost L J; Rodriguez-Abetxuko, Andoni; Erkamp, Nadia A; van Hest, Jan C M; Grisoni, Francesca; Brunsveld, Luc
发表日期：2025
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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex.

针对 14-3-3/ERα 复合物的分子胶的支架跃迁

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-61176-4
Konstantinidou Markella, Zingiridis Marios, Pennings Marloes A M, Fragkiadakis Michael, Virta Johanna M, Revalde Jezrael L, Visser Emira J, Ottmann Christian, Brunsveld Luc, Neochoritis Constantinos G, Arkin Michelle R
其它
发表日期：2025
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Modulation of Protein-Protein Interactions with Molecular Glues in a Synthetic Condensate Platform

利用分子胶在合成凝聚体平台中调控蛋白质-蛋白质相互作用

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.4c17567
van Veldhuisen, Thijs W; Dijkstra, Renske M J; Koops, Auke A; Cossar, Peter J; van Hest, Jan C M; Brunsveld, Luc
信号转导
发表日期：2025
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Stabilization of Condensate Interfaces Using Dynamic Protein Insertion

利用动态蛋白质插入稳定凝聚界面

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c03740
Leurs, Yannick H A; Giezen, Sanne N; Li, Yudong; van den Hout, Willem; Beeren, Jay; van den Aker, Linn J M; Voets, Ilja K; van Hest, Jan C M; Brunsveld, Luc
发表日期：2025
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Proximity-enhanced cysteine-histidine crosslinking for elucidating intrinsically disordered and other protein complexes

利用邻近增强的半胱氨酸-组氨酸交联来阐明固有无序蛋白复合物和其他蛋白复合物

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d4sc07419j
Wu, Qi; van den Wildenberg, Sebastian A H; Brzoskowski, Jeroen C R; van den Oetelaar, Maxime C M; Verhoef, Carlo J A; Genet, Sylvia A A M; Ottmann, Christian; Markvoort, Albert J; Brunsveld, Luc; Cossar, Peter J
发表日期：2025
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Immunoaffinity Intact Top-Down Mass Spectrometry for Quantification of Neuron-Specific Enolase Gamma, a Low-Abundance Protein Biomarker

免疫亲和完整自上而下质谱法定量分析神经元特异性烯醇化酶γ（一种低丰度蛋白质生物标志物）

期刊:Analytical Chemistry
影响因子:6.7
doi:10.1021/acs.analchem.4c04677
van den Wildenberg, Sebastian A H; Genet, Sylvia A A M; Broeren, Maarten A C; van Dongen, Joost L J; van den Oetelaar, Maxime C M; Brunsveld, Luc; Scharnhorst, Volkher; van de Kerkhof, Daan
神经科学
免疫/内分泌
发表日期：2025
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Identifying 14-3-3 interactome binding sites with deep learning

利用深度学习识别 14-3-3 相互作用组的结合位点

期刊:Digital Discovery
影响因子:5.6
doi:10.1039/d5dd00132c
van Weesep, Laura; Özçelik, Rıza; Pennings, Marloes; Criscuolo, Emanuele; Ottmann, Christian; Brunsveld, Luc; Grisoni, Francesca
发表日期：2025
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Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation.

化学计量比的 14-3-3ζ 结合促进磷酸化 Tau 微管解离，减少聚集和凝聚

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-08548-0
Hochmair Janine, van den Oetelaar Maxime C M, Ravatt Leandre, Diez Lisa, Lemmens Lenne J M, Ponce-Lina Renata, Sankar Rithika, Franck Maximilian, Nolte Gesa, Semenova Ekaterina, Mohapatra Satabdee, Ottmann Christian, Brunsveld Luc, Wegmann Susanne
其它
磷酸化
发表日期：2025
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Structural Elucidation and Covalent Modulation of the Autorepressed Orphan Nuclear Receptor NR2F6

自抑制孤儿核受体NR2F6的结构解析和共价调控

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.5c00475
Oerlemans, Guido J M; van den Oetelaar, Maxime C M; van den Elzen, Siebe P; Brunsveld, Luc
信号转导
发表日期：2025
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