日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel Spiro-Barbiturates Can Reverse the Action of General Anesthetics on the GABA(A)R

新型螺环巴比妥类药物可逆转全身麻醉剂对GABA(A)受体的作用。

Koinas, Dimosthenis; Zhou, Xiaojuan; Wu, Bo; Miller, Keith W; Bruzik, Karol S

Spiro Hydantoins Can Reverse the Action of Positive Allosteric Modulators on GABA(A)Rs

螺环乙内酰脲可以逆转正向变构调节剂对GABA(A)R的作用

Koinas, Dimosthenis A; Zhou, Xiaojuan; Bruzik, Karol S; Miller, Keith W

A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors

一种具有新型 GABAA 受体结合位点选择性的强效光反应性全身麻醉剂

Abdelrahman R Shalabi, Zhiyi Yu, Xiaojuan Zhou, Youssef Jounaidi, Hanwen Chen, Jiajia Dai, Daniel E Kent, Hua-Jun Feng, Stuart A Forman, Jonathan B Cohen, Karol S Bruzik, Keith W Miller

Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors

光亲和标记识别异源 GABA A 型 (GABAA) 受体中的亚基间类固醇结合位点

Selwyn S Jayakar, David C Chiara, Xiaojuan Zhou, Bo Wu, Karol S Bruzik, Keith W Miller, Jonathan B Cohen

Quantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis

利用生物传感器测量在临床和日常生活环境中量化多发性硬化症的神经系统疾病

Chitnis, Tanuja; Glanz, Bonnie I; Gonzalez, Cindy; Healy, Brian C; Saraceno, Taylor J; Sattarnezhad, Neda; Diaz-Cruz, Camilo; Polgar-Turcsanyi, Mariann; Tummala, Subhash; Bakshi, Rohit; Bajaj, Vikram S; Ben-Shimol, David; Bikhchandani, Nikhil; Blocker, Alexander W; Burkart, Joshua; Cendrillon, Raphael; Cusack, Michael P; Demiralp, Emre; Jooste, Sarel Kobus; Kharbouch, Alaa; Lee, Amy A; Lehár, Joseph; Liu, Manway; Mahadevan, Swaminathan; Murphy, Mark; Norton, Linda C; Parlikar, Tushar A; Pathak, Anupam; Shoeb, Ali; Soderberg, Erin; Stephens, Philip; Stoertz, Aaron H; Thng, Florence; Tumkur, Kashyap; Wang, Hongsheng; Rhodes, Jane; Rudick, Richard A; Ransohoff, Richard M; Phillips, Glenn A; Bruzik, Effie; Marks, William J; Weiner, Howard L; Snyder, Thomas M

Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo

GABAA 受体上的结合位点位置决定了静脉全身麻醉药混合物在体内是否产生协同作用或附加作用

Daniel E Kent, Pavel Y Savechenkov, Karol S Bruzik, Keith W Miller

Multiple Sclerosis Performance Test: Technical Development and Usability

多发性硬化症功能测试:技术开发和可用性

Rhodes, Jane K; Schindler, David; Rao, Stephen M; Venegas, Fernando; Bruzik, Efrosini T; Gabel, Wendy; Williams, James R; Phillips, Glenn A; Mullen, Colleen C; Freiburger, Jaime L; Mourany, Lyla; Reece, Christine; Miller, Deborah M; Bethoux, Francois; Bermel, Robert A; Krupp, Lauren B; Mowry, Ellen M; Alberts, Jay; Rudick, Richard A

A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor

别孕烯醇酮的光反应类似物可用于识别尼古丁乙酰胆碱受体中的类固醇结合位点。

Yu, Zhiyi; Chiara, David C; Savechenkov, Pavel Y; Bruzik, Karol S; Cohen, Jonathan B

Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands

神经甾体光亲和配体的合成及药理学评价

Savechenkov, Pavel Y; Chiara, David C; Desai, Rooma; Stern, Alexander T; Zhou, Xiaojuan; Ziemba, Alexis M; Szabo, Andrea L; Zhang, Yinghui; Cohen, Jonathan B; Forman, Stuart A; Miller, Keith W; Bruzik, Karol S

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects

致惊厥巴比妥类药物及其抗惊厥对映体对α1β3γ2LGABAA受体的相反作用解释了它们在体内的效应。

Desai, Rooma; Savechenkov, Pavel Y; Zolkowska, Dorota; Ge, Ri Le; Rogawski, Michael A; Bruzik, Karol S; Forman, Stuart A; Raines, Douglas E; Miller, Keith W