日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Probody T Cell-Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity

靶向 EGFR 和 CD3 的 Probody T 细胞结合双特异性抗体可抑制结肠癌生长且毒性有限

Leila M Boustany, Sherry L LaPorte, Laurie Wong, Clayton White, Veena Vinod, Joel Shen, Wendy Yu, David Koditek, Michael B Winter, Stephen J Moore, Li Mei, Linnea Diep, Yuanhui Huang, Shouchun Liu, Olga Vasiljeva, Jim West, Jennifer Richardson, Bryan Irving, Marcia Belvin, W Michael Kavanaugh

Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents

条件性PD-1/PD-L1前体疗法与传统抗PD-1/PD-L1药物相比,可诱导相似的抗肿瘤免疫,但全身毒性更低。

Hikmat H Assi ,Chihunt Wong ,Kimberly A Tipton ,Li Mei ,Ken Wong ,Jennifer Razo ,Chanty Chan ,Bruce Howng ,Jason Sagert ,Michael Krimm ,Linnea Diep ,Andrew Jang ,Margaret T Nguyen ,Nicole Lapuyade ,Victoria Singson ,Ruth Villanueva ,Madan Paidhungat ,Shouchun Liu ,Vangipuram Rangan ,Olga Vasiljeva ,James W West ,Jennifer H Richardson ,Bryan Irving ,Dylan Daniel ,Marcia Belvin ,W Michael Kavanaugh

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

肿瘤和宿主细胞 PD-L1 是介导小鼠抗肿瘤免疫抑制的必要条件

Janet Lau, Jeanne Cheung, Armando Navarro, Steve Lianoglou, Benjamin Haley, Klara Totpal, Laura Sanders, Hartmut Koeppen, Patrick Caplazi, Jacqueline McBride, Henry Chiu, Rebecca Hong, Jane Grogan, Vincent Javinal, Robert Yauch, Bryan Irving, Marcia Belvin, Ira Mellman, Jeong M Kim, Maike Schmidt

MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments

MTRX1011A,一种人源化抗 CD4 单克隆抗体,用于治疗类风湿性关节炎患者:一项结合药效学生物标志物评估的 I 期随机、双盲、安慰剂对照研究

Heleen Scheerens, Zheng Su, Bryan Irving, Michael J Townsend, Yanan Zheng, Eric Stefanich, Vishala Chindalore, Clifton O Bingham 3rd, John C Davis Jr