日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis

TLE3 维持管腔乳腺癌谱系保真度以抑制转移

Lindsey J Anstine, Parth R Majmudar, Amy Aponte, Salendra Singh, Ran Zhao, Kristen L Weber-Bonk, Fadi W Abdul-Karim, Mitchell Valentine, Darcie D Seachrist, Katelyn E Grennel-Nickelson, Leslie Cuellar-Vite, Gina M Sizemore, Steven T Sizemore, Bryan M Webb, Cheryl L Thompson, Ruth A Keri

Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction

CDK7 信号中断会导致灾难性的染色体不稳定性,同时还会导致凝聚蛋白介导的染色质压缩丧失

Katrina M Piemonte, Bryan M Webb, Jessica R Bobbitt, Parth R Majmudar, Leslie Cuellar-Vite, Benjamin L Bryson, Nicholas C Latina, Darcie D Seachrist, Ruth A Keri

TGF-β/activin signaling promotes CDK7 inhibitor resistance in triple-negative breast cancer cells through upregulation of multidrug transporters

TGF-β/促活素信号通过上调多药转运蛋白促进三阴性乳腺癌细胞对 CDK7 抑制剂产生耐药性

Bryan M Webb, Benjamin L Bryson, Eduardo Williams-Medina, Jessica R Bobbitt, Darcie D Seachrist, Lindsey J Anstine, Ruth A Keri

KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene

KLF4 通过抑制 EGFR 基因来定义表皮生长因子受体抑制剂厄洛替尼对三阴性乳腺癌细胞的疗效

Melyssa S Roberts, Lindsey J Anstine, Viviane S Finke, Benjamin L Bryson, Bryan M Webb, Kristen L Weber-Bonk, Darcie D Seachrist, Parth R Majmudar, Ruth A Keri

The transcriptional repressor BCL11A promotes breast cancer metastasis

转录抑制因子 BCL11A 促进乳腺癌转移

Darcie D Seachrist, Molly M Hannigan, Natasha N Ingles, Bryan M Webb, Kristen L Weber-Bonk, Peng Yu, Gurkan Bebek, Salendra Singh, Steven T Sizemore, Vinay Varadan, Donny D Licatalosi, Ruth A Keri

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells

靶向 BCL-xL 可诱导衰老细胞死亡,从而提高溴结构域和末端外蛋白抑制剂对三阴性乳腺癌的疗效

Sylvia S Gayle, Jennifer M Sahni, Bryan M Webb, Kristen L Weber-Bonk, Melyssa S Shively, Raffaella Spina, Eli E Bar, Mathew K Summers, Ruth A Keri

Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors

与 LIN9 相关的三阴性乳腺癌有丝分裂脆弱性可通过 BET 抑制剂进行靶向治疗

Jennifer M Sahni, Sylvia S Gayle, Bryan M Webb, Kristen L Weber-Bonk, Darcie D Seachrist, Salendra Singh, Steven T Sizemore, Nicole A Restrepo, Gurkan Bebek, Peter C Scacheri, Vinay Varadan, Matthew K Summers, Ruth A Keri