日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of covalent chemogenetic K(2P) channel activators.

共价化学遗传K(2P)通道激活剂的开发

Deal Parker E, Lee Haerim, Mondal Abhisek, Lolicato Marco, Mendonça Philipe Ribeiro Furtado de, Black Holly, Jang Seil, El-Hilali Xochina, Bryant Clifford, Isacoff Ehud Y, Renslo Adam R, Minor Daniel L Jr

Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6

激活非催化性半胱氨酸残基可强效且选择性地抑制Caspase-6。

Van Horn, Kurt S; Wang, Dongju; Medina-Cleghorn, Daniel; Lee, Peter S; Bryant, Clifford; Altobelli, Chad; Jaishankar, Priyadarshini; Leung, Kevin K; Ng, Raymond A; Ambrose, Andrew J; Tang, Yinyan; Arkin, Michelle R; Renslo, Adam R

K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site

K(2P)2.1 (TREK-1) 激活复合物揭示了一个隐蔽的选择性过滤器结合位点

Lolicato, Marco; Arrigoni, Cristina; Mori, Takahiro; Sekioka, Yoko; Bryant, Clifford; Clark, Kimberly A; Minor, Daniel L Jr

Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains

不同的2-氨基噻唑类药物在小鼠脑中产生不同的羊瘙痒病朊病毒神经病理学模式

Giles, Kurt; Berry, David B; Condello, Carlo; Hawley, Ronald C; Gallardo-Godoy, Alejandra; Bryant, Clifford; Oehler, Abby; Elepano, Manuel; Bhardwaj, Sumita; Patel, Smita; Silber, B Michael; Guan, Shenheng; DeArmond, Stephen J; Renslo, Adam R; Prusiner, Stanley B

Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease

具有改善的药代动力学特性的四氟苯氧甲基酮类克鲁兹蛋白酶抑制剂可作为治疗恰加斯病的先导化合物

Neitz, R Jeffrey; Bryant, Clifford; Chen, Steven; Gut, Jiri; Hugo Caselli, Estefania; Ponce, Servando; Chowdhury, Somenath; Xu, Haichao; Arkin, Michelle R; Ellman, Jonathan A; Renslo, Adam R

Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice

联芳基酰胺和腙类化合物作为转基因小鼠朊病毒病的治疗药物

Lu, Duo; Giles, Kurt; Li, Zhe; Rao, Satish; Dolghih, Elena; Gever, Joel R; Geva, Michal; Elepano, Manuel L; Oehler, Abby; Bryant, Clifford; Renslo, Adam R; Jacobson, Matthew P; Dearmond, Stephen J; Silber, B Michael; Prusiner, Stanley B

2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease

2-氨基噻唑类化合物具有改善的药理治疗特性,可用于治疗朊病毒病

Li, Zhe; Silber, B Michael; Rao, Satish; Gever, Joel R; Bryant, Clifford; Gallardo-Godoy, Alejandra; Dolghih, Elena; Widjaja, Kartika; Elepano, Manuel; Jacobson, Matthew P; Prusiner, Stanley B; Renslo, Adam R

Predicting binding to p-glycoprotein by flexible receptor docking

通过柔性受体对接预测与P-糖蛋白的结合

Dolghih, Elena; Bryant, Clifford; Renslo, Adam R; Jacobson, Matthew P

Divergent modes of enzyme inhibition in a homologous structure-activity series

同源结构-活性系列中酶抑制的不同模式

Ferreira, Rafaela S; Bryant, Clifford; Ang, Kenny K H; McKerrow, James H; Shoichet, Brian K; Renslo, Adam R