日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases

英国犬血小板减少症的病因:一项对762例病例的回顾性研究

Martín-Ambrosio Francés, Marina; Seth, Mayank; Sharman, Mellora; Pollard, Danica; Ortiz, Ana Liza; Miller, Rachel; Natsiopoulos, Thomas; Walker, David; Jones, Bryn; Hardwick, Joshua; Glanemann, Barbara; Garcia, Andrés Salas; Bacon, Jessica; Selgas, Aida Gómez

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

BRCA2-RAD51 相互作用的小分子抑制剂可调节 RAD51 组装并增强 DNA 损伤引起的细胞死亡

Duncan E Scott, Nicola J Francis-Newton, May E Marsh, Anthony G Coyne, Gerhard Fischer, Tommaso Moschetti, Andrew R Bayly, Timothy D Sharpe, Kalina T Haas, Lorraine Barber, Chiara R Valenzano, Rajavel Srinivasan, David J Huggins, Miyoung Lee, Amy Emery, Bryn Hardwick, Matthias Ehebauer, Claudio Dago

The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis

药物溶剂 N-甲基-2-吡咯烷酮 (NMP) 通过激活 Krüppel 样因子 2 来减轻炎症,从而减少动脉粥样硬化的形成

Marta Roche-Molina #, Bryn Hardwick #, Cristina Sanchez-Ramos, David Sanz-Rosa, Dirk Gewert, Francisco M Cruz, Andres Gonzalez-Guerra, Vicente Andres, Joaquin A Palma, Borja Ibanez, Grahame Mckenzie, Juan A Bernal

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

polo 样激酶 PLK1 的 polo-box 结构域中的隐秘疏水口袋调节底物识别和有丝分裂染色体分离

Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman

Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS

调节有丝分裂 Polo 样激酶的蛋白质-蛋白质相互作用以靶向突变型 KRAS

Ana J Narvaez, Suzan Ber, Alex Crooks, Amy Emery, Bryn Hardwick, Estrella Guarino Almeida, David J Huggins, David Perera, Meredith Roberts-Thomson, Roberta Azzarelli, Fiona E Hood, Ian A Prior, David W Walker, Richard Boyce, Robert G Boyle, Samuel P Barker, Christopher J Torrance, Grahame J McKenzie

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2

通过小分子抑制剂对 AURKA 激酶活性进行变构调节,抑制其与 TPX2 的蛋白质-蛋白质相互作用

Matej Janeček, Maxim Rossmann, Pooja Sharma, Amy Emery, David J Huggins, Simon R Stockwell, Jamie E Stokes, Yaw S Tan, Estrella Guarino Almeida, Bryn Hardwick, Ana J Narvaez, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman