日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Fat or flat? The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules

胖还是扁？偶极矩矢量对芳香标签与大分子间非共价相互作用的影响

期刊:Inorganic Chemistry Frontiers
影响因子:6.4
doi:10.1039/d5qi01546d
Holub, Josef; Jílková, Adéla; Lemke, Carina; Cianni, Lorenzo; Spiwoková, Petra; Horn, Martin; Breuer, Christian; Leontovyč, Adrian; Brynda, Jiří; Mertlíková-Kaiserová, Helena; Chanová, Marta; Dos Reis Rocho, Fernanda; Montanari, Carlos A; El-Sakkary, Nelly; Caffrey, Conor R; Gütschow, Michael; Hnyk, Drahomír; Mareš, Michael; Fanfrlík, Jindřich
发表日期：2026
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Steroidal A/B-ring fusion as a strategy for isoform-selective inhibition of human carbonic anhydrases

甾体A/B环融合作为选择性抑制人碳酸酐酶的策略

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra06507k
Brynda, Jiří; Kiss, Anita; Pospíšilová, Klára; Kapras, Vojtěch; Sieglová, Irena; Slavíková, Barbora; Řezáčová, Pavlína; Kudová, Eva
发表日期：2026
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Affinity and Selectivity of Protein-Ligand Recognition: A Minor Chemical Modification Changes Carbonic Anhydrase Binding Profile

蛋白质-配体识别的亲和力和选择性：微小的化学修饰改变碳酸酐酶的结合谱

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01421
Zakšauskas, Audrius; Paketurytė-Latvė, Vaida; Janku̅naitė, Alberta; Čapkauskaitė, Edita; Becart, Yann; Smirnov, Alexey; Pospíšilová, Klára; Leitans, Janis; Brynda, Jiří; Kazaks, Andris; Baranauskienė, Lina; Manakova, Elena; Gražulis, Saulius; Kairys, Visvaldas; Tars, Kaspars; Řezáčová, Pavlína; Matulis, Daumantas
发表日期：2025
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On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

新型隐球菌 May1 大环抑制剂的树脂上组装：通往强效抗真菌剂的途径

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00396
Kryštůfek Robin, Verner Václav, Šácha Pavel, Hadzima Martin, Trajhan Filip, Starková Jana, Tloušt'ová Eva, Dvořáková Alexandra, Pecina Adam, Brynda Jiří, Chalupský Karel, Hájek Miroslav, Boucher Michael J, Majer Pavel, Řezáč Jan, Madhani Hiten D, Craik Charles S, Konvalinka Jan
微生物学
发表日期：2025
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Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors

超越天然类黄酮：探索生物等排性在流感核酸内切酶抑制剂设计与合成中的应用

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00071h
Reiberger, Róbert; Kráľ, Michal; Radilová, Kateřina; Kotačka, Tomáš; Dračínský, Martin; Tsalyy, Artem; Brynda, Jiří; Majer, Pavel; Konvalinka, Jan; Kožíšek, Milan; Machara, Aleš
微生物学
流感
发表日期：2025
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Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis

源自自然的加林酰胺是有效的抗血吸虫剂：抑制组织蛋白酶 B1 蛋白酶靶标和结合模式分析

期刊:ACS Infectious Diseases
影响因子:4
doi:10.1021/acsinfecdis.3c00589
Petra Spiwoková, Martin Horn, Jindřich Fanfrlík, Adéla Jílková, Pavla Fajtová, Adrian Leontovyč, Radka Houštecká, Lucia Bieliková, Jiří Brynda, Marta Chanová, Helena Mertlíková-Kaiserová, Eduardo J E Caro-Diaz, Jehad Almaliti, Nelly El-Sakkary, William H Gerwick, Conor R Caffrey, Michael Mareš
信号转导
发表日期：2024
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Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

新型嘌呤核苷磷酸化酶抑制剂的设计、合成、生物学评价及晶体学研究

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.2c02097
Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský, Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt'ová, Zuzana Král'ová, Markéta Šmídková, Jan Voldřich, Michaela Rumlová, Petr Pachl, Jiří Brynda, Tereza Vučková, Milan Fábry, Jan Snášel, Iva Pichová, Pavlína Ř
表观遗传
发表日期：2023
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PLCL/PCL Dressings with Platelet Lysate and Growth Factors Embedded in Fibrin for Chronic Wound Regeneration

含有血小板裂解物和生长因子的纤维蛋白 PLCL/PCL 敷料用于慢性伤口再生

期刊:International Journal of Nanomedicine
影响因子:6.6
doi:10.2147/IJN.S393890
Johanka Táborská, Andreu Blanquer, Eduard Brynda, Elena Filová, Lenka Stiborová, Věra Jenčová, Kristýna Havlíčková, Zuzana Riedelová, Tomáš Riedel
信号转导
血小板
ELISA
发表日期：2023
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X-ray structure of human aldo-keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis

人醛酮还原酶1C3与胆汁酸稠合四唑抑制剂复合物的X射线晶体结构：实验验证、分子对接和结构分析

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d2md00387b
Marinović, Maja A; Bekić, Sofija S; Kugler, Michael; Brynda, Jiří; Škerlová, Jana; Škorić, Dušan Đ; Řezáčová, Pavlína; Petri, Edward T; Ćelić, Andjelka S
发表日期：2023
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Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists

新型 7-脱氮嘌呤环二核苷酸类似物作为 STING 受体激动剂的设计、合成及生化和生物学评价

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.2c01305
Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, Gabriel Birkuš
STING
信号转导
发表日期：2022
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