日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bacterial ligases reveal fundamental principles of polyubiquitin specificity

细菌连接酶揭示了多聚泛素特异性的基本原理

Franklin, Tyler G; Brzovic, Peter S; Pruneda, Jonathan N

Bacterial mimicry of eukaryotic HECT ubiquitin ligation

细菌对真核生物HECT泛素连接的模拟

Franklin, Tyler G; Brzovic, Peter S; Pruneda, Jonathan N

The ubiquitin ligase SspH1 from Salmonella uses a modular and dynamic E3 domain to catalyze substrate ubiquitylation

沙门氏菌的泛素连接酶SspH1利用模块化和动态的E3结构域催化底物泛素化。

Cook, Matt; Delbecq, Scott P; Schweppe, Thomas P; Guttman, Miklos; Klevit, Rachel E; Brzovic, Peter S

Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector

军团菌单个效应蛋白介导的磷酸核糖基泛素化机制

Akturk, Anil; Wasilko, David J; Wu, Xiaochun; Liu, Yao; Zhang, Yong; Qiu, Jiazhang; Luo, Zhao-Qing; Reiter, Katherine H; Brzovic, Peter S; Klevit, Rachel E; Mao, Yuxin

E2 enzymes: more than just middle men

E2酶:不仅仅是中间商

Stewart, Mikaela D; Ritterhoff, Tobias; Klevit, Rachel E; Brzovic, Peter S

Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b

辅助蛋白TRIP8b调控HCN离子通道的结构机制

DeBerg, Hannah A; Bankston, John R; Rosenbaum, Joel C; Brzovic, Peter S; Zagotta, William N; Stoll, Stefan

Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases

调控调控因子:E3泛素连接酶调控的最新发现

Vittal, Vinayak; Stewart, Mikaela D; Brzovic, Peter S; Klevit, Rachel E

E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis

E2~Ub缀合物在致病过程中调节志贺氏菌效应蛋白OspG的激酶活性。

Pruneda, Jonathan N; Smith, F Donelson; Daurie, Angela; Swaney, Danielle L; Villén, Judit; Scott, John D; Stadnyk, Andrew W; Le Trong, Isolde; Stenkamp, Ronald E; Klevit, Rachel E; Rohde, John R; Brzovic, Peter S

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

通过高通量诱变鉴定的 E3 泛素连接酶活性增强突变

Starita Lea M, Pruneda Jonathan N, Lo Russell S, Fowler Douglas M, Kim Helen J, Hiatt Joseph B, Shendure Jay, Brzovic Peter S, Fields Stanley, Klevit Rachel E

Biochemical and structural characterization of the ubiquitin-conjugating enzyme UBE2W reveals the formation of a noncovalent homodimer

对泛素结合酶UBE2W的生化和结构表征揭示了非共价同源二聚体的形成。

Vittal, Vinayak; Wenzel, Dawn M; Brzovic, Peter S; Klevit, Rachel E