日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M(1) positive allosteric modulator VU0467319 for Alzheimer's disease: a single ascending-dose study in healthy participants

毒蕈碱M(1)正向变构调节剂VU0467319治疗阿尔茨海默病的安全性、耐受性、药代动力学和药效学效应:一项在健康受试者中进行的单次递增剂量研究

Conley, Alexander C; Key, Alexandra P; Blackford, Jennifer U; Russell, Jason K; Albert, Kimberly M; Gong, Xuewen; Bubser, Michael; Rook, Jerri M; Conn, P Jeffrey; Lindsley, Craig W; Jones, Carrie K; Newhouse, Paul A

Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)

选择性和中枢神经系统渗透性炔基TREK抑制剂的优化:ONO-9517601 (VU6022856) 和 ONO-7927846 (VU6024391) 的发现和表征

Tanaka, Motoyuki; Sekioka, Yoko; Hashimoto, Gakuji; Mori, Takahiro; Shono, Tomoyuki; Isaji, Yuuki; Hisaichi, Katsuya; Childress, Elizabeth S; Bollinger, Sean; Schmitt, Joza A; Chopko, Trevor C; Garrison, Aaron T; Perry, Charles K; Chronister, Keagan; Kramer, Meghan; Chang, Sichen; Watson, Katherine J; Dickerson, Jonathan W; Bubser, Michael; Rook, Jerri M; Jones, Carrie K; Boutaud, Olivier; Bridges, Thomas M; Denton, Jerod S; Engers, Darren W; Kurata, Haruto; Lindsley, Craig W

Discovery of VU6052254: A Novel, Potent M(1) Positive Allosteric Modulator

VU6052254 的发现:一种新型、强效的 M(1) 正向变构调节剂

Engers, Julie L; Bungard, Joseph D; Presley, Christopher C; Zagol-Ikapitte, Irene; Watson, Katherine J; Chang, Sichen; O'Carroll, Colin; Dey, P Markus; Burstein, Ethan S; Dickerson, Jonathan W; Thompson Gray, Analisa; Bubser, Michael; Rook, Jerri M; Cho, Hyekyung P; Kramlinger, Valerie M; Boutaud, Olivier; Jones, Carrie K; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W

Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M(5) Muscarinic Acetylcholine Receptor

VU6036864 的开发:一种基于三唑并吡啶的高质量 M(5) 毒蕈碱乙酰胆碱受体拮抗剂工具化合物

Li, Jinming; Orsi, Douglas L; Engers, Julie L; Long, Madeline F; Capstick, Rory A; Maurer, Mallory A; Presley, Christopher C; Vinson, Paige N; Rodriguez, Alice L; Han, Allie; Cho, Hyekyung P; Chang, Sichen; Jackson, Megan; Bubser, Michael; Blobaum, Anna L; Boutaud, Olivier; Nader, Michael A; Niswender, Colleen M; Conn, P Jeffrey; Jones, Carrie K; Lindsley, Craig W; Han, Changho

Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

VU6016235 的发现:一种高选择性、口服生物利用度高且结构独特的三环 M(4) 毒蕈碱乙酰胆碱受体正向变构调节剂 (PAM)

Engers, Julie L; Baker, Logan A; Chang, Sichen; Luscombe, Vincent B; Rodriguez, Alice L; Niswender, Colleen M; Cho, Hyekyung P; Bubser, Michael; Gray, Analisa Thompson; Jones, Carrie K; Peng, Weimin; Rook, Jerri M; Bridges, Thomas M; Boutaud, Olivier; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W; Temple, Kayla J

Clinical recommendations for polygenic risk score-enhanced breast cancer screening: Can.Heal project

基于多基因风险评分的乳腺癌筛查临床建议:Can.Heal 项目

Bubser, Michael; Bridges, Thomas M; Dencker, Ditte; Gould, Robert W; Grannan, Michael; Noetzel, Meredith J; Lamsal, Atin; Niswender, Colleen M; Daniels, J Scott; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Byers, Frank W; Wess, Jürgen; Duggan, Mark E; Dunlop, John; Wood, Michael W; Brandon, Nicholas J; Wood, Michael R; Lindsley, Craig W; Conn, P Jeffrey; Jones, Carrie K; Taha, A; Matt McCrary, J; van Rooij, J; Lahousse, L; Paoletti, F; Pascucci, E; Vaht, M; Pastorino, R; Pezzullo, A M; Boccia, S

Early initiation of antibiotic therapy and short-term outcomes in preterm infants: a single-centre retrospective cohort analysis

早期应用抗生素治疗对早产儿短期预后的影响:一项单中心回顾性队列分析

Köstlin-Gille, Natascha; Serna-Higuita, Lina Maria; Bubser, Caren; Arand, Joerg; Haag, Laura; Schwarz, Christoph E; Heideking, Martin; Poets, Christian F; Gille, Christian

Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis

早期抗生素暴露对极早产儿潜在病原体定植风险的影响:一项回顾性队列分析

Bubser, Caren; Liese, Jan; Serna-Higuita, Lina Maria; Müller, Andreas; Vochem, Matthias; Arand, Jörg; Karck, Ulrich; Gross, Maximilian; Poets, Christian F; Härtel, Christoph; Zemlin, Michael; Gille, Christian; Köstlin-Gille, Natascha

Modulation of arousal and sleep/wake architecture by M(1) PAM VU0453595 across young and aged rodents and nonhuman primates

M(1) PAM VU0453595 对幼年和老年啮齿动物以及非人灵长类动物的觉醒和睡眠/觉醒结构的调节

Gould, Robert W; Russell, Jason K; Nedelcovych, Michael T; Bubser, Michael; Blobaum, Anna L; Bridges, Thomas M; Newhouse, Paul A; Lindsley, Craig W; Conn, P Jeffrey; Nader, Michael A; Jones, Carrie K

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

GIRK 激活剂 VU0466551 单独使用及与吗啡联合使用在急性及持续性疼痛模型中的镇痛效果

Abney, Kristopher K; Bubser, Michael; Du, Yu; Kozek, Krystian A; Bridges, Thomas M; Linsdley, Craig W; Daniels, J Scott; Morrison, Ryan D; Wickman, Kevin; Hopkins, Corey R; Jones, Carrie K; Weaver, C David