日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

ADT-030 是一种新型 PDE10 抑制剂，在胰腺导管腺癌中表现出强大的抗肿瘤活性。

期刊:
影响因子:
doi:10.64898/2026.02.11.705411
Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Foote, Jeremy B; Keeton, Adam B; Chen, Xi; Ramirez-Alcantara, Veronica; Holmes, Thomas; Akce, Mehmet; Singh, Anju; Powell, Craig M; Behera, Santosh; Azmi, Asfar S; Nurmemmedov, Elmar; Babic, Ivan; Gorman, Gregory S; Coward, Lori; Buchsbaum, Donald J; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F
肿瘤
肿瘤免疫
PDE10
发表日期：2026
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ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

ADT-1004：一种首创的口服泛RAS抑制剂，在胰腺导管腺癌的临床前模型中具有强大的抗肿瘤活性

期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-025-02288-9
Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Carstens, Julienne L; Foote, Jeremy B; Graff, Emily C; Fang, Yu-Hua D; Keeton, Adam B; Chen, Xi; Valiyaveettil, Jacob; Berry, Kristy L; Bae, Sejong; Akce, Mehmet; Gorman, Greg; Yoon, Karina J; Manne, Upender; Boyd, Michael R; Buchsbaum, Donald J; Azmi, Asfar S; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F
RAS
肿瘤
肿瘤免疫
发表日期：2025
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A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

一种具有独特作用机制的泛 RAS 抑制剂可抑制肿瘤生长并诱导胃肠道癌症的抗肿瘤免疫

期刊:Cancer Research
影响因子:16.6
doi:10.1158/0008-5472.CAN-24-0323
Foote Jeremy B, Mattox Tyler E, Keeton Adam B, Chen Xi, Smith Forrest T, Berry Kristy, Holmes Thomas W, Wang Junwei, Huang Chung-Hui, Ward Antonio, Mitra Amit K, Ramirez-Alcantara Veronica, Hardy Cherlene, Fleten Karianne G, Flatmark Kjersti, Yoon Karina J, Sarvesh Sujith, Nagaraju Ganji P, Bandi Dhana Sekhar Reddy, Maxuitenko Yulia Y, Valiyaveettil Jacob, Carstens Julienne L, Buchsbaum Donald J, Yang Jennifer, Zhou Gang, Nurmemmedov Elmar, Babic Ivan, Gaponeko Vadim, Abdelkarim Hazem, Boyd Michael R, Gorman Greg, Manne Upender, Bae Sejong, El-Rayes Bassel F, Piazza Gary A
肿瘤
肿瘤免疫
发表日期：2025
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Evaluation of a Novel Pan-RAS Inhibitor in 3D Bioprinted Tumor Models

在3D生物打印肿瘤模型中评估一种新型泛RAS抑制剂

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers17182958
De Nobrega, Daniela D; Eiler, Logan C; Ahirwar, Parmanand; Nallapu, Sonika; Rawal, Urvi P; Crawford, Chelsea L; Buchsbaum, Donald J; Keeton, Adam B; Maxuitenko, Yulia Y; Chen, Xi; Piazza, Gary A; Tsung, Allan; Budhwani, Karim I
3D/类器官
RAS
肿瘤
肿瘤免疫
发表日期：2025
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Editorial: RAS inhibitor therapy of cancer

社论：RAS抑制剂治疗癌症

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2025.1685295
Buchsbaum, Donald J; Nassar, Nicolas N; Piazza, Gary A
RAS
肿瘤
肿瘤免疫
发表日期：2025
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Potency and selectivity of a novel pan-RAS inhibitor in 3D bioprinted organoid tumor models

新型泛RAS抑制剂在3D生物打印类器官肿瘤模型中的效力和选择性

期刊:
影响因子:
doi:10.1101/2025.02.25.640132
De Nobrega, Daniela; Eiler, Logan C; Ahirwar, Parmanand; Rawal, Urvi P; Crawford, Chelsea L; Buchsbaum, Donald J; Keeton, Adam B; Maxuitenko, Yulia Y; Chen, Xi; Piazza, Gary A; Tsung, Allan; Budhwani, Karim I
3D/类器官
RAS
肿瘤
肿瘤免疫
发表日期：2025
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Editorial: Targeting the Wnt/β-catenin signaling pathway in cancer

社论：靶向Wnt/β-catenin信号通路治疗癌症

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2022.1022174
Patergnani, Simone; Buchsbaum, Donald J; Piazza, Gary A
信号转导
肿瘤
Wnt/β-Catenin
肿瘤免疫
发表日期：2022
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PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

PDE5 和 PDE10 抑制剂可激活 cGMP/PKG 信号通路，从而阻断 Wnt/β-catenin 转录、癌细胞生长和肿瘤免疫。

期刊:Drug Discovery Today
影响因子:7.5
doi:10.1016/j.drudis.2020.06.008
Piazza, Gary A; Ward, Antonio; Chen, Xi; Maxuitenko, Yulia; Coley, Alex; Aboelella, Nada S; Buchsbaum, Donald J; Boyd, Michael R; Keeton, Adam B; Zhou, Gang
信号转导
免疫/内分泌
肿瘤
PDE10
Wnt/β-Catenin
细胞生物学
肿瘤免疫
发表日期：2020
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B7-H3-targeted Radioimmunotherapy of Human Cancer

B7-H3靶向放射免疫疗法治疗人类癌症

期刊:Current Medicinal Chemistry
影响因子:3.5
doi:10.2174/0929867326666190228120908
Kasten, Benjamin B; Ferrone, Soldano; Zinn, Kurt R; Buchsbaum, Donald J
Human
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2020
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Histone deacetylase inhibition promotes intratumoral CD8(+) T-cell responses, sensitizing murine breast tumors to anti-PD1.

组蛋白去乙酰化酶抑制可促进肿瘤内 CD8(+) T 细胞反应，使小鼠乳腺肿瘤对 PD-1 抗体敏感

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-019-02430-9
McCaw Tyler R, Li Mei, Starenki Dmytro, Liu Mingyong, Cooper Sara J, Arend Rebecca C, Forero Andres, Buchsbaum Donald J, Randall Troy D
肿瘤
CD8
乙酰化
发表日期：2019
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