日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Recent breakthroughs in understanding the allosteric features of Ras GTPases and their effector and regulatory protein interactions, enabling drug design

近年来,在理解Ras GTP酶的变构特征及其效应蛋白和调节蛋白相互作用方面取得了突破性进展,这为药物设计提供了可能。

Bhattarai, Nisha; Buck, Matthias

Structural basis for ligand promiscuity and high signaling activity of Kaposi's Sarcoma-associated Herpesvirus-encoded GPCR.

卡波西肉瘤相关疱疹病毒编码的 GPCR 配体混杂性和高信号活性的结构基础。

Park Jun Bae, Sahoo Bibekananda, Sahoo Amita Rani, Kim Dokyun, Seo Hogyu David, Bowman James, Kwak Mi-Jeong, Suh Sophia, Buck Matthias, Dai Xinghong, Jung Jae U

Computational model predicts function of Rho-GTPase binding for plexin receptor GAP activity on Rap1b via dynamic allosteric changes

计算模型预测 Rho-GTPase 结合通过动态变构变化影响 Rap1b 上 plexin 受体 GAP 活性的功能

Bhattarai, Nisha; Morrison, Lindsay; Gomes, Alexandre F; Savage, Paul; Sahoo, Amita R; Buck, Matthias

Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptor.

胆固醇抑制 EphA2 受体的组装和致癌激活

Schuck Ryan J, Ward Alyssa E, Sahoo Amita R, Rybak Jennifer A, Pyron Robert J, Trybala Thomas N, Simmons Timothy B, Baccile Joshua A, Sgouralis Ioannis, Buck Matthias, Lamichhane Rajan, Barrera Francisco N

Cholesterol-dependent dimerization and conformational dynamics of EphA2 receptors from coarse-grained and all-atom simulations

基于粗粒化和全原子模拟的EphA2受体胆固醇依赖性二聚化和构象动力学

Sahoo, Amita Rani; Bhattarai, Nisha; Buck, Matthias

STEM-13. CYTOMEGALOVIRUS-ENCODED GPCR, US28, DRIVES GLIOMA STEM CELL EXPANSION

STEM-13. 巨细胞病毒编码的G蛋白偶联受体US28驱动胶质瘤干细胞扩增

Sahoo, Amita R; Bhattarai, Nisha; Buck, Matthias; Qi, Xu; Sloan, Anthony; Wass, Amanda; Lathia, Justin; O’Connor, Christine

Tyrosine phosphorylation and the inhibitory C-terminal SAM domain moderately affect transient interactions in a EphA2 cytoplasmic fragment in solution: A combined experimental and molecular modeling study

酪氨酸磷酸化和抑制性C端SAM结构域对溶液中EphA2胞质片段的瞬时相互作用有中等程度的影响:一项结合实验和分子建模的研究

Shrestha, Pravesh; Sahoo, Amita Rani; Iannucci, Maria; Willard, Belinda; Buck, Matthias

Cholesterol-Dependent Dimerization and Conformational Dynamics of EphA2 Receptors: Insights from Coarse-Grained and All-Atom Simulations

胆固醇依赖性EphA2受体二聚化和构象动力学:来自粗粒化和全原子模拟的启示

Sahoo, Amita Rani; Bhattarai, Nisha; Buck, Matthias

Computation model predicts Rho GTPase function with the Plexin Transmembrane receptor GAP activity on Rap1b via dynamic allosteric changes

计算模型预测,Rho GTPase 功能通过动态变构变化与 Plexin 跨膜受体 GAP 活性共同作用于 Rap1b。

Bhattarai, Nisha; Morrison, Lindsay; Gomes, Alexandre F; Savage, Paul; Sahoo, Amita R; Buck, Matthias

Macropinocytosis mediates neurotropism of Cryptococcus neoformans in a human organoid model of the blood-brain barrier.

在人类血脑屏障类器官模型中,巨胞饮作用介导新型隐球菌的神经趋向性。

Bennett Amelia B, Lanser Dylan M, Vu Kiem, Sahoo Amita R, Buck Matthias, Gelli Angie