日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

全基因组关联研究荟萃分析为心力衰竭及其亚型的病因学提供了新的见解

Henry, Albert; Mo, Xiaodong; Finan, Chris; Chaffin, Mark D; Speed, Doug; Issa, Hanane; Denaxas, Spiros; Ware, James S; Zheng, Sean L; Malarstig, Anders; Gratton, Jasmine; Bond, Isabelle; Roselli, Carolina; Miller, David; Chopade, Sandesh; Schmidt, A Floriaan; Abner, Erik; Adams, Lance; Andersson, Charlotte; Aragam, Krishna G; Ärnlöv, Johan; Asselin, Geraldine; Raja, Anna Axelsson; Backman, Joshua D; Bartz, Traci M; Biddinger, Kiran J; Biggs, Mary L; Bloom, Heather L; Boersma, Eric; Brandimarto, Jeffrey; Brown, Michael R; Brunak, Søren; Bruun, Mie Topholm; Buckbinder, Leonard; Bundgaard, Henning; Carey, David J; Chasman, Daniel I; Chen, Xing; Cook, James P; Czuba, Tomasz; de Denus, Simon; Dehghan, Abbas; Delgado, Graciela E; Doney, Alexander S; Dörr, Marcus; Dowsett, Joseph; Dudley, Samuel C; Engström, Gunnar; Erikstrup, Christian; Esko, Tõnu; Farber-Eger, Eric H; Felix, Stephan B; Finer, Sarah; Ford, Ian; Ghanbari, Mohsen; Ghasemi, Sahar; Ghouse, Jonas; Giedraitis, Vilmantas; Giulianini, Franco; Gottdiener, John S; Gross, Stefan; Guðbjartsson, Daníel F; Gui, Hongsheng; Gutmann, Rebecca; Hägg, Sara; Haggerty, Christopher M; Hedman, Åsa K; Helgadottir, Anna; Hemingway, Harry; Hillege, Hans; Hyde, Craig L; Aagaard Jensen, Bitten; Jukema, J Wouter; Kardys, Isabella; Karra, Ravi; Kavousi, Maryam; Kizer, Jorge R; Kleber, Marcus E; Køber, Lars; Koekemoer, Andrea; Kuchenbaecker, Karoline; Lai, Yi-Pin; Lanfear, David; Langenberg, Claudia; Lin, Honghuang; Lind, Lars; Lindgren, Cecilia M; Liu, Peter P; London, Barry; Lowery, Brandon D; Luan, Jian'an; Lubitz, Steven A; Magnusson, Patrik; Margulies, Kenneth B; Marston, Nicholas A; Martin, Hilary; März, Winfried; Melander, Olle; Mordi, Ify R; Morley, Michael P; Morris, Andrew P; Morrison, Alanna C; Morton, Lori; Nagle, Michael W; Nelson, Christopher P; Niessner, Alexander; Niiranen, Teemu; Noordam, Raymond; Nowak, Christoph; O'Donoghue, Michelle L; Ostrowski, Sisse Rye; Owens, Anjali T; Palmer, Colin N A; Paré, Guillaume; Pedersen, Ole Birger; Perola, Markus; Pigeyre, Marie; Psaty, Bruce M; Rice, Kenneth M; Ridker, Paul M; Romaine, Simon P R; Rotter, Jerome I; Ruff, Christian T; Sabatine, Marc S; Sallah, Neneh; Salomaa, Veikko; Sattar, Naveed; Shalaby, Alaa A; Shekhar, Akshay; Smelser, Diane T; Smith, Nicholas L; Sørensen, Erik; Srinivasan, Sundararajan; Stefansson, Kari; Sveinbjörnsson, Garðar; Svensson, Per; Tammesoo, Mari-Liis; Tardif, Jean-Claude; Teder-Laving, Maris; Teumer, Alexander; Thorgeirsson, Guðmundur; Thorsteinsdottir, Unnur; Torp-Pedersen, Christian; Tragante, Vinicius; Trompet, Stella; Uitterlinden, Andre G; Ullum, Henrik; van der Harst, Pim; van Heel, David; van Setten, Jessica; van Vugt, Marion; Veluchamy, Abirami; Verschuuren, Monique; Verweij, Niek; Vissing, Christoffer Rasmus; Völker, Uwe; Voors, Adriaan A; Wallentin, Lars; Wang, Yunzhang; Weeke, Peter E; Wiggins, Kerri L; Williams, L Keoki; Yang, Yifan; Yu, Bing; Zannad, Faiez; Zheng, Chaoqun; Asselbergs, Folkert W; Cappola, Thomas P; Dubé, Marie-Pierre; Dunn, Michael E; Lang, Chim C; Samani, Nilesh J; Shah, Svati; Vasan, Ramachandran S; Smith, J Gustav; Holm, Hilma; Shah, Sonia; Ellinor, Patrick T; Hingorani, Aroon D; Wells, Quinn; Lumbers, R Thomas

STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

STX-478 是一种突变选择性变构 PI3Kα 抑制剂,可避免代谢功能障碍并改善 PI3Kα 突变异种移植的治疗反应

Leonard Buckbinder, David J St Jean Jr, Trang Tieu, Brendon Ladd, Brendan Hilbert, Weixue Wang, Jacob T Alltucker #, Samantha Manimala, Gregory V Kryukov, Natasja Brooijmans, Gregory Dowdell, Philip Jonsson #, Michael Huff, Angel Guzman-Perez, Erica L Jackson, Marcus D Goncalves, Darrin D Stuart

Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction

髓过氧化物酶PET成像追踪实验性心肌梗死中细胞内和细胞外治疗变化

Zeller, Matthias W G; Wang, Cuihua; Keliher, Edmund J; Wojtkiewicz, Gregory R; Aguirre, Aaron; Maresca, Kevin; Su, Chunyan; Buckbinder, Leonard; Wang, Jing; Nahrendorf, Matthias; Chen, John W

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

全基因组关联分析和孟德尔随机化分析为了解心力衰竭的发病机制提供了新的视角。

Shah, Sonia; Henry, Albert; Roselli, Carolina; Lin, Honghuang; Sveinbjörnsson, Garðar; Fatemifar, Ghazaleh; Hedman, Åsa K; Wilk, Jemma B; Morley, Michael P; Chaffin, Mark D; Helgadottir, Anna; Verweij, Niek; Dehghan, Abbas; Almgren, Peter; Andersson, Charlotte; Aragam, Krishna G; Ärnlöv, Johan; Backman, Joshua D; Biggs, Mary L; Bloom, Heather L; Brandimarto, Jeffrey; Brown, Michael R; Buckbinder, Leonard; Carey, David J; Chasman, Daniel I; Chen, Xing; Chen, Xu; Chung, Jonathan; Chutkow, William; Cook, James P; Delgado, Graciela E; Denaxas, Spiros; Doney, Alexander S; Dörr, Marcus; Dudley, Samuel C; Dunn, Michael E; Engström, Gunnar; Esko, Tõnu; Felix, Stephan B; Finan, Chris; Ford, Ian; Ghanbari, Mohsen; Ghasemi, Sahar; Giedraitis, Vilmantas; Giulianini, Franco; Gottdiener, John S; Gross, Stefan; Guðbjartsson, Daníel F; Gutmann, Rebecca; Haggerty, Christopher M; van der Harst, Pim; Hyde, Craig L; Ingelsson, Erik; Jukema, J Wouter; Kavousi, Maryam; Khaw, Kay-Tee; Kleber, Marcus E; Køber, Lars; Koekemoer, Andrea; Langenberg, Claudia; Lind, Lars; Lindgren, Cecilia M; London, Barry; Lotta, Luca A; Lovering, Ruth C; Luan, Jian'an; Magnusson, Patrik; Mahajan, Anubha; Margulies, Kenneth B; März, Winfried; Melander, Olle; Mordi, Ify R; Morgan, Thomas; Morris, Andrew D; Morris, Andrew P; Morrison, Alanna C; Nagle, Michael W; Nelson, Christopher P; Niessner, Alexander; Niiranen, Teemu; O'Donoghue, Michelle L; Owens, Anjali T; Palmer, Colin N A; Parry, Helen M; Perola, Markus; Portilla-Fernandez, Eliana; Psaty, Bruce M; Rice, Kenneth M; Ridker, Paul M; Romaine, Simon P R; Rotter, Jerome I; Salo, Perttu; Salomaa, Veikko; van Setten, Jessica; Shalaby, Alaa A; Smelser, Diane T; Smith, Nicholas L; Stender, Steen; Stott, David J; Svensson, Per; Tammesoo, Mari-Liis; Taylor, Kent D; Teder-Laving, Maris; Teumer, Alexander; Thorgeirsson, Guðmundur; Thorsteinsdottir, Unnur; Torp-Pedersen, Christian; Trompet, Stella; Tyl, Benoit; Uitterlinden, Andre G; Veluchamy, Abirami; Völker, Uwe; Voors, Adriaan A; Wang, Xiaosong; Wareham, Nicholas J; Waterworth, Dawn; Weeke, Peter E; Weiss, Raul; Wiggins, Kerri L; Xing, Heming; Yerges-Armstrong, Laura M; Yu, Bing; Zannad, Faiez; Zhao, Jing Hua; Hemingway, Harry; Samani, Nilesh J; McMurray, John J V; Yang, Jian; Visscher, Peter M; Newton-Cheh, Christopher; Malarstig, Anders; Holm, Hilma; Lubitz, Steven A; Sattar, Naveed; Holmes, Michael V; Cappola, Thomas P; Asselbergs, Folkert W; Hingorani, Aroon D; Kuchenbaecker, Karoline; Ellinor, Patrick T; Lang, Chim C; Stefansson, Kari; Smith, J Gustav; Vasan, Ramachandran S; Swerdlow, Daniel I; Lumbers, R Thomas

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo

可激活的PET成像放射性探针是一种体内髓过氧化物酶活性的动态报告分子。

Wang, Cuihua; Keliher, Edmund; Zeller, Matthias W G; Wojtkiewicz, Gregory R; Aguirre, Aaron D; Buckbinder, Leonard; Kim, Hye-Yeong; Chen, Jianqing; Maresca, Kevin; Ahmed, Maaz S; Motlagh, Negin Jalali; Nahrendorf, Matthias; Chen, John W

Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition

小鼠髓过氧化物酶抑制改变动脉粥样硬化病变组成

Rachel J Roth Flach, Chunyan Su, Eliza Bollinger, Christian Cortes, Andrew W Robertson, Alan C Opsahl, Timothy M Coskran, Kevin P Maresca, Edmund J Keliher, Phillip D Yates, Albert M Kim, Amit S Kalgutkar, Leonard Buckbinder

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

内皮蛋白激酶 MAP4K4 促进血管炎症和动脉粥样硬化

Rachel J Roth Flach, Athanasia Skoura, Anouch Matevossian, Laura V Danai, Wei Zheng, Christian Cortes, Samit K Bhattacharya, Myriam Aouadi, Nana Hagan, Joseph C Yawe, Pranitha Vangala, Lorena Garcia Menendez, Marcus P Cooper, Timothy P Fitzgibbons, Leonard Buckbinder, Michael P Czech

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

发现一种体内工具来建立基于 MAP4K4 的抗糖尿病治疗的概念验证

Mark Ammirati, Scott W Bagley, Samit K Bhattacharya, Leonard Buckbinder, Anthony A Carlo, Rebecca Conrad, Christian Cortes, Robert L Dow, Matthew S Dowling, Ayman El-Kattan, Kristen Ford, Cristiano R W Guimarães, David Hepworth, Wenhua Jiao, Jennifer LaPerle, Shenping Liu, Allyn Londregan, Paula M L

PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle

PYK2 选择性地介导响应自发性血管平滑肌拉伸的生长与分化信号

Anirban Bhattachariya, Karolina M Turczyńska, Mario Grossi, Ina Nordström, Leonard Buckbinder, Sebastian Albinsson, Per Hellstrand

Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner

细胞粘附减少以 Pyk2 依赖的方式促进血管生成

Colette J Shen, Srivatsan Raghavan, Zhe Xu, Jan D Baranski, Xiang Yu, Michele A Wozniak, Jordan S Miller, Mudit Gupta, Leonard Buckbinder, Christopher S Chen