日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset

西班牙人群中帕金森病HMGCR基因变异:与脂质代谢和早发病的关系

Díaz-Belloso, Rafael; Martín-Bornez, Miguel; Macías-García, Daniel; García-Díaz, Sergio; Bonilla-Toribio, Marta; Buiza-Rueda, Dolores; Sánchez, Rocío Pineda; Muñoz-Delgado, Laura; Ojeda, Elena; Jesús, Silvia; Adarmes-Gómez, Astrid; Carrillo, Fátima; Mir, Pablo; Gómez-Garre, Pilar

A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC

西班牙-葡萄牙人群进行的进行性核上性麻痹全基因组关联研究揭示了NFAS中的一个新的风险位点

García-González, Pablo; Rodrigo Lara, Héctor; Compta, Yaroslau; Fernandez, Manuel; van der Lee, Sven J; de Rojas, Itziar; Saiz, Laura; Painous, Celia; Camara, Ana; Muñoz, Esteban; Marti, Maria J; Valldeoriola, Francesc; Puerta, Raquel; Illán-Gala, Ignacio; Pagonabarraga, Javier; Dols-Icardo, Oriol; Kulisevsky, Jaime; Fortea, Juan; Lleó, Alberto; Olivé, Claudia; de Boer, Sterre C M; Hulsman, Marc; Pijnenburg, Yolande A L; Díaz Belloso, Rafael; Muñoz-Delgado, Laura; Buiza Rueda, Dolores; Gómez-Garre, Pilar; Aldecoa, Iban; Aragonés, Gemma; Hernandez Vara, Jorge; Mendioroz, Maite; Pérez-Tur, Jordi; Visser, Pieter Jelle; den Braber, Anouk; Papma, Janne M; Martín Montes, Ángel; Rodriguez-Rodriguez, Eloy; Blázquez-Folch, Josep; Miguel, Andrea; García-Gutiérrez, Fernando; Cano, Amanda; Valero, Sergi; Marquié, Marta; Capdevila-Bayo, María; Rosende-Roca, Maitee; Quintela, Inés; Carracedo, Ángel; Tàrraga, Lluís; Real, Luis M; Royo, Jose Luis; Erro, María Elena; Guerrero, Carmen; Corte Torres, Daniela; Blázquez-Estrada, Marta; San Millán, Beatriz; Teijeira, Susana; Vilas Rolan, Dolores; Hernández, Isabel; Sánchez-Soblechero, Antonio; de la Casa-Fages, Beatriz; Serrano López, Soledad; Baviera-Muñoz, Raquel; Lavín, Amaya; Taipa, Ricardo; Amer, Guillermo; Martinez-Saez, Elena; Fernández-Matarrubia, Marta; Lage-Martínez, Carmen; Álvarez, Victoria; Molina-Porcel, Laura; Holstege, Henne; Mir, Pablo; Belbin, Olivia; Boada, Mercè; Fernández, Victoria; Bullido, María J; Rábano, Alberto; Sánchez-Juan, Pascual; Ruiz, Agustín

Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

作者更正:阿尔茨海默病常见变异及基于多基因风险评分的风险分层

de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E; Pedersen, Nancy L; Stringa, Najada; Zettergren, Anna; Hernández, Isabel; Montrreal, Laura; Antúnez, Carmen; Antonell, Anna; Tankard, Rick M; Bis, Joshua C; Sims, Rebecca; Bellenguez, Céline; Quintela, Inés; González-Perez, Antonio; Calero, Miguel; Franco-Macías, Emilio; Macías, Juan; Blesa, Rafael; Cervera-Carles, Laura; Menéndez-González, Manuel; Frank-García, Ana; Royo, Jose Luís; Moreno, Fermin; Huerto Vilas, Raquel; Baquero, Miquel; Diez-Fairen, Mónica; Lage, Carmen; García-Madrona, Sebastián; García-González, Pablo; Alarcón-Martín, Emilio; Valero, Sergi; Sotolongo-Grau, Oscar; Ullgren, Abbe; Naj, Adam C; Lemstra, Afina W; Benaque, Alba; Pérez-Cordón, Alba; Benussi, Alberto; Rábano, Alberto; Padovani, Alessandro; Squassina, Alessio; de Mendonça, Alexandre; Arias Pastor, Alfonso; Kok, Almar A L; Meggy, Alun; Pastor, Ana Belén; Espinosa, Ana; Corma-Gómez, Anaïs; Martín Montes, Angel; Sanabria, Ángela; DeStefano, Anita L; Schneider, Anja; Haapasalo, Annakaisa; Kinhult Ståhlbom, Anne; Tybjærg-Hansen, Anne; Hartmann, Annette M; Spottke, Annika; Corbatón-Anchuelo, Arturo; Rongve, Arvid; Borroni, Barbara; Arosio, Beatrice; Nacmias, Benedetta; Nordestgaard, Børge G; Kunkle, Brian W; Charbonnier, Camille; Abdelnour, Carla; Masullo, Carlo; Martínez Rodríguez, Carmen; Muñoz-Fernandez, Carmen; Dufouil, Carole; Graff, Caroline; Ferreira, Catarina B; Chillotti, Caterina; Reynolds, Chandra A; Fenoglio, Chiara; Van Broeckhoven, Christine; Clark, Christopher; Pisanu, Claudia; Satizabal, Claudia L; Holmes, Clive; Buiza-Rueda, Dolores; Aarsland, Dag; Rujescu, Dan; Alcolea, Daniel; Galimberti, Daniela; Wallon, David; Seripa, Davide; Grünblatt, Edna; Dardiotis, Efthimios; Düzel, Emrah; Scarpini, Elio; Conti, Elisa; Rubino, Elisa; Gelpi, Ellen; Rodriguez-Rodriguez, Eloy; Duron, Emmanuelle; Boerwinkle, Eric; Ferri, Evelyn; Tagliavini, Fabrizio; Küçükali, Fahri; Pasquier, Florence; Sanchez-Garcia, Florentino; Mangialasche, Francesca; Jessen, Frank; Nicolas, Gaël; Selbæk, Geir; Ortega, Gemma; Chêne, Geneviève; Hadjigeorgiou, Georgios; Rossi, Giacomina; Spalletta, Gianfranco; Giaccone, Giorgio; Grande, Giulia; Binetti, Giuliano; Papenberg, Goran; Hampel, Harald; Bailly, Henri; Zetterberg, Henrik; Soininen, Hilkka; Karlsson, Ida K; Alvarez, Ignacio; Appollonio, Ildebrando; Giegling, Ina; Skoog, Ingmar; Saltvedt, Ingvild; Rainero, Innocenzo; Rosas Allende, Irene; Hort, Jakub; Diehl-Schmid, Janine; Van Dongen, Jasper; Vidal, Jean-Sebastien; Lehtisalo, Jenni; Wiltfang, Jens; Thomassen, Jesper Qvist; Kornhuber, Johannes; Haines, Jonathan L; Vogelgsang, Jonathan; Pineda, Juan A; Fortea, Juan; Popp, Julius; Deckert, Jürgen; Buerger, Katharina; Morgan, Kevin; Fließbach, Klaus; Sleegers, Kristel; Molina-Porcel, Laura; Kilander, Lena; Weinhold, Leonie; Farrer, Lindsay A; Wang, Li-San; Kleineidam, Luca; Farotti, Lucia; Parnetti, Lucilla; Tremolizzo, Lucio; Hausner, Lucrezia; Benussi, Luisa; Froelich, Lutz; Ikram, M Arfan; Deniz-Naranjo, M Candida; Tsolaki, Magda; Rosende-Roca, Maitée; Löwenmark, Malin; Hulsman, Marc; Spallazzi, Marco; Pericak-Vance, Margaret A; Esiri, Margaret; Bernal Sánchez-Arjona, María; Dalmasso, Maria Carolina; Martínez-Larrad, María Teresa; Arcaro, Marina; Nöthen, Markus M; Fernández-Fuertes, Marta; Dichgans, Martin; Ingelsson, Martin; Herrmann, Martin J; Scherer, Martin; Vyhnalek, Martin; Kosmidis, Mary H; Yannakoulia, Mary; Schmid, Matthias; Ewers, Michael; Heneka, Michael T; Wagner, Michael; Scamosci, Michela; Kivipelto, Miia; Hiltunen, Mikko; Zulaica, Miren; Alegret, Montserrat; Fornage, Myriam; Roberto, Natalia; van Schoor, Natasja M; Seidu, Nazib M; Banaj, Nerisa; Armstrong, Nicola J; Scarmeas, Nikolaos; Scherbaum, Norbert; Goldhardt, Oliver; Hanon, Oliver; Peters, Oliver; Skrobot, Olivia Anna; Quenez, Olivier; Lerch, Ondrej; Bossù, Paola; Caffarra, Paolo; Dionigi Rossi, Paolo; Sakka, Paraskevi; Mecocci, Patrizia; Hoffmann, Per; Holmans, Peter A; Fischer, Peter; Riederer, Peter; Yang, Qiong; Marshall, Rachel; Kalaria, Rajesh N; Mayeux, Richard; Vandenberghe, Rik; Cecchetti, Roberta; Ghidoni, Roberta; Frikke-Schmidt, Ruth; Sorbi, Sandro; Hägg, Sara; Engelborghs, Sebastiaan; Helisalmi, Seppo; Botne Sando, Sigrid; Kern, Silke; Archetti, Silvana; Boschi, Silvia; Fostinelli, Silvia; Gil, Silvia; Mendoza, Silvia; Mead, Simon; Ciccone, Simona; Djurovic, Srdjan; Heilmann-Heimbach, Stefanie; Riedel-Heller, Steffi; Kuulasmaa, Teemu; Del Ser, Teodoro; Lebouvier, Thibaud; Polak, Thomas; Ngandu, Tiia; Grimmer, Timo; Bessi, Valentina; Escott-Price, Valentina; Giedraitis, Vilmantas; Deramecourt, Vincent; Maier, Wolfgang; Jian, Xueqiu; Pijnenburg, Yolande A L; Kehoe, Patrick Gavin; Garcia-Ribas, Guillermo; Sánchez-Juan, Pascual; Pastor, Pau; Pérez-Tur, Jordi; Piñol-Ripoll, Gerard; Lopez de Munain, Adolfo; García-Alberca, Jose María; Bullido, María J; Álvarez, Victoria; Lleó, Alberto; Real, Luis M; Mir, Pablo; Medina, Miguel; Scheltens, Philip; Holstege, Henne; Marquié, Marta; Sáez, María Eugenia; Carracedo, Ángel; Amouyel, Philippe; Schellenberg, Gerard D; Williams, Julie; Seshadri, Sudha; van Duijn, Cornelia M; Mather, Karen A; Sánchez-Valle, Raquel; Serrano-Ríos, Manuel; Orellana, Adelina; Tárraga, Lluís; Blennow, Kaj; Huisman, Martijn; Andreassen, Ole A; Posthuma, Danielle; Clarimón, Jordi; Boada, Mercè; van der Flier, Wiesje M; Ramirez, Alfredo; Lambert, Jean-Charles; van der Lee, Sven J; Ruiz, Agustín

Peripheral inflammatory immune response differs among sporadic and familial Parkinson's disease

散发性和家族性帕金森病患者的外周炎症免疫反应存在差异

Muñoz-Delgado, Laura; Macías-García, Daniel; Periñán, María Teresa; Jesús, Silvia; Adarmes-Gómez, Astrid D; Bonilla Toribio, Marta; Buiza Rueda, Dolores; Jiménez-Jaraba, María Del Valle; Benítez Zamora, Belén; Díaz Belloso, Rafael; García-Díaz, Sergio; Martín-Bórnez, Miguel; Pineda Sánchez, Rocío; Carrillo, Fátima; Gómez-Garre, Pilar; Mir, Pablo

Author Correction: Peripheral inflammatory immune response differs among sporadic and familial Parkinson's disease

作者更正:散发性和家族性帕金森病患者的外周炎症免疫反应存在差异

Muñoz-Delgado, Laura; Macías-García, Daniel; Periñán, María Teresa; Jesús, Silvia; Adarmes-Gómez, Astrid D; Bonilla Toribio, Marta; Buiza Rueda, Dolores; Jiménez-Jaraba, María Del Valle; Benítez Zamora, Belén; Díaz Belloso, Rafael; García-Díaz, Sergio; Martín-Bórnez, Miguel; Pineda Sánchez, Rocío; Carrillo, Fátima; Gómez-Garre, Pilar; Mir, Pablo

Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease

帕金森病患者的同型半胱氨酸水平、遗传背景和认知障碍

Periñán, María Teresa; Macías-García, Daniel; Jesús, Silvia; Martín-Rodríguez, Juan Francisco; Muñoz-Delgado, Laura; Jimenez-Jaraba, Maria Valle; Buiza-Rueda, Dolores; Bonilla-Toribio, Marta; Adarmes-Gómez, Astrid Daniela; Gómez-Garre, Pilar; Mir, Pablo

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

阿尔茨海默病常见变异及基于多基因风险评分的风险分层

de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E; Pedersen, Nancy L; Stringa, Najada; Zettergren, Anna; Hernández, Isabel; Montrreal, Laura; Antúnez, Carmen; Antonell, Anna; Tankard, Rick M; Bis, Joshua C; Sims, Rebecca; Bellenguez, Céline; Quintela, Inés; González-Perez, Antonio; Calero, Miguel; Franco-Macías, Emilio; Macías, Juan; Blesa, Rafael; Cervera-Carles, Laura; Menéndez-González, Manuel; Frank-García, Ana; Royo, Jose Luís; Moreno, Fermin; Huerto Vilas, Raquel; Baquero, Miquel; Diez-Fairen, Mónica; Lage, Carmen; García-Madrona, Sebastián; García-González, Pablo; Alarcón-Martín, Emilio; Valero, Sergi; Sotolongo-Grau, Oscar; Ullgren, Abbe; Naj, Adam C; Lemstra, Afina W; Benaque, Alba; Pérez-Cordón, Alba; Benussi, Alberto; Rábano, Alberto; Padovani, Alessandro; Squassina, Alessio; de Mendonça, Alexandre; Arias Pastor, Alfonso; Kok, Almar A L; Meggy, Alun; Pastor, Ana Belén; Espinosa, Ana; Corma-Gómez, Anaïs; Martín Montes, Angel; Sanabria, Ángela; DeStefano, Anita L; Schneider, Anja; Haapasalo, Annakaisa; Kinhult Ståhlbom, Anne; Tybjærg-Hansen, Anne; Hartmann, Annette M; Spottke, Annika; Corbatón-Anchuelo, Arturo; Rongve, Arvid; Borroni, Barbara; Arosio, Beatrice; Nacmias, Benedetta; Nordestgaard, Børge G; Kunkle, Brian W; Charbonnier, Camille; Abdelnour, Carla; Masullo, Carlo; Martínez Rodríguez, Carmen; Muñoz-Fernandez, Carmen; Dufouil, Carole; Graff, Caroline; Ferreira, Catarina B; Chillotti, Caterina; Reynolds, Chandra A; Fenoglio, Chiara; Van Broeckhoven, Christine; Clark, Christopher; Pisanu, Claudia; Satizabal, Claudia L; Holmes, Clive; Buiza-Rueda, Dolores; Aarsland, Dag; Rujescu, Dan; Alcolea, Daniel; Galimberti, Daniela; Wallon, David; Seripa, Davide; Grünblatt, Edna; Dardiotis, Efthimios; Düzel, Emrah; Scarpini, Elio; Conti, Elisa; Rubino, Elisa; Gelpi, Ellen; Rodriguez-Rodriguez, Eloy; Duron, Emmanuelle; Boerwinkle, Eric; Ferri, Evelyn; Tagliavini, Fabrizio; Küçükali, Fahri; Pasquier, Florence; Sanchez-Garcia, Florentino; Mangialasche, Francesca; Jessen, Frank; Nicolas, Gaël; Selbæk, Geir; Ortega, Gemma; Chêne, Geneviève; Hadjigeorgiou, Georgios; Rossi, Giacomina; Spalletta, Gianfranco; Giaccone, Giorgio; Grande, Giulia; Binetti, Giuliano; Papenberg, Goran; Hampel, Harald; Bailly, Henri; Zetterberg, Henrik; Soininen, Hilkka; Karlsson, Ida K; Alvarez, Ignacio; Appollonio, Ildebrando; Giegling, Ina; Skoog, Ingmar; Saltvedt, Ingvild; Rainero, Innocenzo; Rosas Allende, Irene; Hort, Jakub; Diehl-Schmid, Janine; Van Dongen, Jasper; Vidal, Jean-Sebastien; Lehtisalo, Jenni; Wiltfang, Jens; Thomassen, Jesper Qvist; Kornhuber, Johannes; Haines, Jonathan L; Vogelgsang, Jonathan; Pineda, Juan A; Fortea, Juan; Popp, Julius; Deckert, Jürgen; Buerger, Katharina; Morgan, Kevin; Fließbach, Klaus; Sleegers, Kristel; Molina-Porcel, Laura; Kilander, Lena; Weinhold, Leonie; Farrer, Lindsay A; Wang, Li-San; Kleineidam, Luca; Farotti, Lucia; Parnetti, Lucilla; Tremolizzo, Lucio; Hausner, Lucrezia; Benussi, Luisa; Froelich, Lutz; Ikram, M Arfan; Deniz-Naranjo, M Candida; Tsolaki, Magda; Rosende-Roca, Maitée; Löwenmark, Malin; Hulsman, Marc; Spallazzi, Marco; Pericak-Vance, Margaret A; Esiri, Margaret; Bernal Sánchez-Arjona, María; Dalmasso, Maria Carolina; Martínez-Larrad, María Teresa; Arcaro, Marina; Nöthen, Markus M; Fernández-Fuertes, Marta; Dichgans, Martin; Ingelsson, Martin; Herrmann, Martin J; Scherer, Martin; Vyhnalek, Martin; Kosmidis, Mary H; Yannakoulia, Mary; Schmid, Matthias; Ewers, Michael; Heneka, Michael T; Wagner, Michael; Scamosci, Michela; Kivipelto, Miia; Hiltunen, Mikko; Zulaica, Miren; Alegret, Montserrat; Fornage, Myriam; Roberto, Natalia; van Schoor, Natasja M; Seidu, Nazib M; Banaj, Nerisa; Armstrong, Nicola J; Scarmeas, Nikolaos; Scherbaum, Norbert; Goldhardt, Oliver; Hanon, Oliver; Peters, Oliver; Skrobot, Olivia Anna; Quenez, Olivier; Lerch, Ondrej; Bossù, Paola; Caffarra, Paolo; Dionigi Rossi, Paolo; Sakka, Paraskevi; Mecocci, Patrizia; Hoffmann, Per; Holmans, Peter A; Fischer, Peter; Riederer, Peter; Yang, Qiong; Marshall, Rachel; Kalaria, Rajesh N; Mayeux, Richard; Vandenberghe, Rik; Cecchetti, Roberta; Ghidoni, Roberta; Frikke-Schmidt, Ruth; Sorbi, Sandro; Hägg, Sara; Engelborghs, Sebastiaan; Helisalmi, Seppo; Botne Sando, Sigrid; Kern, Silke; Archetti, Silvana; Boschi, Silvia; Fostinelli, Silvia; Gil, Silvia; Mendoza, Silvia; Mead, Simon; Ciccone, Simona; Djurovic, Srdjan; Heilmann-Heimbach, Stefanie; Riedel-Heller, Steffi; Kuulasmaa, Teemu; Del Ser, Teodoro; Lebouvier, Thibaud; Polak, Thomas; Ngandu, Tiia; Grimmer, Timo; Bessi, Valentina; Escott-Price, Valentina; Giedraitis, Vilmantas; Deramecourt, Vincent; Maier, Wolfgang; Jian, Xueqiu; Pijnenburg, Yolande A L; Kehoe, Patrick Gavin; Garcia-Ribas, Guillermo; Sánchez-Juan, Pascual; Pastor, Pau; Pérez-Tur, Jordi; Piñol-Ripoll, Gerard; Lopez de Munain, Adolfo; García-Alberca, Jose María; Bullido, María J; Álvarez, Victoria; Lleó, Alberto; Real, Luis M; Mir, Pablo; Medina, Miguel; Scheltens, Philip; Holstege, Henne; Marquié, Marta; Sáez, María Eugenia; Carracedo, Ángel; Amouyel, Philippe; Schellenberg, Gerard D; Williams, Julie; Seshadri, Sudha; van Duijn, Cornelia M; Mather, Karen A; Sánchez-Valle, Raquel; Serrano-Ríos, Manuel; Orellana, Adelina; Tárraga, Lluís; Blennow, Kaj; Huisman, Martijn; Andreassen, Ole A; Posthuma, Danielle; Clarimón, Jordi; Boada, Mercè; van der Flier, Wiesje M; Ramirez, Alfredo; Lambert, Jean-Charles; van der Lee, Sven J; Ruiz, Agustín

Serum lipid profile among sporadic and familial forms of Parkinson's disease

散发性和家族性帕金森病患者的血清脂质谱

Macías-García, Daniel; Periñán, María Teresa; Muñoz-Delgado, Laura; Jimenez-Jaraba, María Valle; Labrador-Espinosa, Miguel Ángel; Jesús, Silvia; Buiza-Rueda, Dolores; Méndez-Del Barrio, Carlota; Adarmes-Gómez, Astrid; Gómez-Garre, Pilar; Mir, Pablo

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

痴呆症患者和对照人群中与SARS-CoV-2感染相关的宿主因素的基因组特征分析:GR@ACE/DEGESCO研究

de Rojas, Itziar; Hernández, Isabel; Montrreal, Laura; Quintela, Inés; Calero, Miguel; Royo, Jose Luís; Huerto Vilas, Raquel; González-Pérez, Antonio; Franco-Macías, Emilio; Macías, Juan; Menéndez-González, Manuel; Frank-García, Ana; Diez-Fairen, Mónica; Lage, Carmen; García-Madrona, Sebastián; Aguilera, Nuria; García-González, Pablo; Puerta, Raquel; Sotolongo-Grau, Oscar; Alonso-Lana, Silvia; Rábano, Alberto; Arias Pastor, Alfonso; Pastor, Ana Belén; Corma-Gómez, Anaïs; Martín Montes, Angel; Martínez Rodríguez, Carmen; Buiza-Rueda, Dolores; Periñán, Maria Teresa; Rodriguez-Rodriguez, Eloy; Alvarez, Ignacio; Rosas Allende, Irene; Pineda, Juan A; Bernal Sánchez-Arjona, María; Fernández-Fuertes, Marta; Mendoza, Silvia; Del Ser, Teodoro; Gr Ace/Degesco Consortium; Garcia-Ribas, Guillermo; Sánchez-Juan, Pascual; Pastor, Pau; Bullido, María J; Álvarez, Victoria; Real, Luis M; Mir, Pablo; Piñol-Ripoll, Gerard; García-Alberca, Jose María; Medina, Miguel; Orellana, Adelina; Butler, Chris R; Marquié, Marta; Sáez, María Eugenia; Carracedo, Ángel; Tárraga, Lluís; Boada, Mercè; Ruiz, Agustín

A genetic analysis of a Spanish population with early onset Parkinson's disease

对西班牙早发性帕金森病患者群体的基因分析

Cristina, Tejera-Parrado; Pablo, Mir; Teresa, Periñán María; Lydia, Vela-Desojo; Irene, Abreu-Rodríguez; Araceli, Alonso-Cánovas; Inmaculada, Bernal-Bernal; Marta, Bonilla-Toribio; Dolores, Buiza-Rueda; José, Catalán-Alonso María; Rocío, García-Ramos; José, García-Ruiz Pedro; Ismael, Huertas-Fernández; Silvia, Jesús; Labrador, Miguel A-Espinosa; Lydia, López-Manzanares; Carlos, Martínez-Castrillo Juan; Posada, Ignacio J; Ana, Rojo-Sebastián; Cristina, Ruiz-Huete; Javier, Del Val; Gómez-Garre, Pilar