日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

以 E3 连接酶组为中心的基因汇编揭示了人类 E3 连接酶的全貌。

Chua Ngee Kiat, González-Robles Tania J, Reddington Cameron J, Dudley-Fraser Jane, Birkinshaw Richard W, Han Jiru, Solano Ashleigh, Wong Soon Wei, Kochańczyk Tomasz, Peter Joshua J, Nakasone Mark A, Aust Florian, Munro Jacob, Tong Yeh Huei, Iskander Julie, Abeysekera Waruni, Garnham Alex, Huckstep Hannah, Ritchie Matthew E, Wertz Ingrid, Hymowitz Sarah, Kumar Sharad, Conaway Ron C, Privé Gilbert G, Bullock Alex N, Babon Jeffrey J, Klevit Rachel E, Lorenz Sonja, Ciulli Alessio, Fischer Eric S, Thomä Nicolas H, Nowak Radosław P, Schulman Brenda A, Rapé Michael, Rittinger Katrin, Pagan Julia K, Bahlo Melanie, Mackay Joel P, Mace Peter D, Lima Christopher D, Hay Ronald T, Komander David, Lechtenberg Bernhard C, Joazeiro Claudio A P, Pagano Michele, Hofmann Kay, Feltham Rebecca

Ubiquitin E3 ligase KLHL6 brings exhausted T-cells back into action

泛素E3连接酶KLHL6使耗竭的T细胞重新激活。

Chen, Zhuoyao; Bullock, Alex N; Kessler, Benedikt M

Fragment-Based Drug Discovery of Novel High-affinity, Selective, and Anti-inflammatory Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction

基于片段的新型高亲和力、选择性抗炎抑制剂在Keap1-Nrf2蛋白-蛋白相互作用中的应用

Lin, Chunyu; Narayanan, Dilip; Barreca, Marilia; Poulsen, Cecilie; da Costa, Leandro Silva; Chen, Xiangrong; Wichman, Kendall G; Charley, Cherisse A; Lindsay, Jaslin L; Dezfouli, Mahya; Vlissari, Dimitra; Mortensen, Thomas S; Chan, Camilla B; Wang, Jingyi; Richardson, William; Manning, Charlotte E; Chen, Zhuoyao; Zang, Jie; Käck, Helena; Gajhede, Michael; Bullock, Alex N; Blake, David J; Olagnier, David; Bach, Anders

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.

UM171 的结构模拟和新生癌症突变体利用 E3 连接酶 KBTBD4 募集 HDAC1/2

Chen Zhuoyao, Chi Gamma, Balo Timea, Chen Xiangrong, Montes Beatriz Ralsi, Clifford Steven C, D'Angiolella Vincenzo, Szabo Timea, Kiss Arpad, Novak Tibor, Herner András, Kotschy András, Bullock Alex N

Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open

迈向2035年目标:EUbOPEN——一项旨在促进和开放生物学的公私合作项目

Tredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J; Bullock, Alex N; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M; Elkins, Jonathan M; Farin, Henner F; Fon, Edward A; Gstaiger, Matthias; Günther, Judith; Gustavsson, Anna-Lena; Häberle, Sandra; Isigkeit, Laura; Huber, Kilian V M; Kotschy, Andras; Krämer, Oliver; Leach, Andrew R; Marsden, Brian D; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P C; Müller, Susanne; Owen, Dafydd R; Proschak, Ewgenij; Röhm, Sandra; Stolz, Alexandra; Sundström, Michael; von Delft, Frank; Willson, Timothy M; Arrowsmith, Cheryl H; Knapp, Stefan

Discovery of Conformationally Constrained ALK2 Inhibitors

构象受限的ALK2抑制剂的发现

González-Álvarez, Héctor; Ensan, Deeba; Xin, Tao; Wong, Jong Fu; Zepeda-Velázquez, Carlos A; Cros, Julien; Sweeney, Melissa N; Hoffer, Laurent; Kiyota, Taira; Wilson, Brian J; Aman, Ahmed; Roberts, Owen; Isaac, Methvin B; Bullock, Alex N; Smil, David; Al-Awar, Rima

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

具有极高选择性的KEAP1共价抑制剂

Fejes Imre, Markacz Piroska, Tatai Janos, Rudas Monika, Dunkel Petra, Gyuris Mario, Nyerges Miklos, Provost Nicolas, Duvivier Valérie, Delerive Philippe, Martiny Virginie, Bristiel Alexandra, Vidal Brice, Richardson William, Rothweiler Elisabeth M, Tranberg-Jensen Jeppe, Manning Charlotte E, Sweeney Melissa N, Chalk Rod, Huber Kilian V M, Bullock Alex N, Herner Andras, Seedorf Klaus, Vinson Cedric, Weber Csaba, Kotschy Andras

A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1

KCTD1的五聚体结构和TFAP2A结合依赖于BTB延伸和离子结合域。

Pinkas, Daniel M; Bufton, Joshua C; Hunt, Alice E; Manning, Charlotte E; Richardson, William; Bullock, Alex N

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.

结构和生化表征建立了对 KEAP1-CUL3 复合物组装的详细了解

Adamson Roslin J, Payne N Connor, Bartual Sergio G, Mazitschek Ralph, Bullock Alex N

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

丝氨酸/苏氨酸激酶细胞周期蛋白依赖性激酶样蛋白5 (CDKL5) 特异性抑制剂的发现和表征揭示了其在海马CA1区生理功能中的作用。

Castano, Anna; Silvestre, Margaux; Wells, Carrow I; Sanderson, Jennifer L; Ferrer, Carla A; Ong, Han Wee; Lang, Yi; Richardson, William; Silvaroli, Josie A; Bashore, Frances M; Smith, Jeffery L; Genereux, Isabelle M; Dempster, Kelvin; Drewry, David H; Pabla, Navlot S; Bullock, Alex N; Benke, Tim A; Ultanir, Sila; Axtman, Alison D