日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pain Signaling by GPCRs and RTKs

GPCR和RTK介导的疼痛信号传导

Schmidt, Brain L; De Logu, Francesco; Nassini, Romina; Geppetti, Pierangelo; Bunnett, Nigel W

A Bacteroides fragilis protease activates host PAR(2) to induce intestinal pain and inflammation.

脆弱拟杆菌蛋白酶激活宿主PAR(2),诱发肠道疼痛和炎症。

Lakemeyer Markus, Latorre Rocco, Blazkova Kristyna, Wood Hannah M, Jensen Dane D, Shakil Nayab, Thomas Scott C, Saxena Deepak, Mulpuri Yatendra, Poolman David, Duran Paz, Keller Laura J, Reed David E, Schmidt Brian L, Jiménez-Vargas Néstor N, Xu Fangxi, Lomax Alan E, Bunnett Nigel W, Bogyo Matthew

Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation

靶向雪旺细胞中的前列腺素E2受体2可抑制炎症性疼痛,但不会抑制炎症。

Romina Nassini,Lorenzo Landini,Matilde Marini,Martina Chieca,Daniel Souza Monteiro de Araújo,Marco Montini,Pasquale Pensieri,Vittorio Donato Abruzzese,Gaetano De Siena,Jin Zhang,Elisa Bellantoni,Vincenzo De Giorgi,Antonia Romitelli,Giulia Brancolini,Raquel Tonello,Chloe J Peach,Alessandra Mastricci,Irene Scuffi,Martina Tesi,Dane D Jensen,Brian L Schmidt,Nigel W Bunnett,Francesco De Logu #,Pierangelo Geppetti #

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

口腔癌细胞和伤害感受器上的PAR2会导致口腔癌疼痛,而纳米颗粒包裹的AZ3451可以缓解这种疼痛。

Divya Bhansali ,Nguyen H Tu ,Kenji Inoue ,Shavonne Teng ,Tianyu Li ,Hung D Tran ,Dong H Kim ,Jessy Dong ,Chloe J Peach ,Badr Sokrat ,Dane D Jensen ,John C Dolan ,Seiichi Yamano ,Valeria Mezzano Robinson ,Nigel W Bunnett ,Donna G Albertson ,Kam W Leong ,Brian L Schmidt

Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia

靶向内体中蛋白酶激活受体2的纳米药物可提供持续镇痛作用

Teng, Shavonne L; Latorre, Rocco; Bhansali, Divya; Lewis, Parker K; Pollard, Rachel E; Peach, Chloe J; Sokrat, Badr; Thanigai Arasu, Gokul Sriman; Chiu, Tracy; Duran, Paz; Jimenez-Vargas, Nestor N; Mocherniak, Abby; Bogyo, Matthew; Gaspari, Michael M; Vanner, Stephen J; Pinkerton, Nathalie M; W Leong, Kam; Schmidt, Brian L; Jensen, Dane D; Bunnett, Nigel W

A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation

在小鼠结肠炎症模型中,一种pH敏感型阿片类药物未表现出镇痛耐受性。

Degro, Claudius E; Jiménez-Vargas, Nestor Nivardo; Guzman-Rodriguez, Mabel; Schincariol, Hailey; Tsang, Quentin; Reed, David E; Lomax, Alan E; Bunnett, Nigel W; Stein, Christoph; Vanner, Stephen J

Endophilin A1 and synaptojanin 1-dependent endocytosis of synaptic vesicles in nociceptive spinal circuits maintains postoperative and cancer pain.

脊髓伤害性回路中内吞蛋白 A1 和突触蛋白 1 依赖的突触小泡内吞作用维持着术后疼痛和癌症疼痛

Pessano Fialho Maria Fernanda, Thanigai Arasu Gokul Sriman, Chen Shen, Imlach Wendy L, Bunnett Nigel W, Tonello Raquel

N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain

幼稚和发炎小鼠结肠的 N 端组学分析揭示了 Legumain 的蛋白水解特征

Alexander R Ziegler, Bethany M Anderson, Rocco Latorre, Rachel M McQuade, Antoine Dufour, Brian L Schmidt, Nigel W Bunnett, Nichollas E Scott, Laura E Edgington-Mitchell

Probing the activity of cysteine cathepsins in inflammatory bowel diseases

探究半胱氨酸蛋白酶在炎症性肠病中的活性

Anderson, Bethany M; Ziegler, Alexander R; Campden, Rhiannon I; Wu, Hongyi; Xu, Bangyan; McQuade, Rachel M; Carbone, Simona E; Poole, Daniel P; Lomax, Alan E; Reed, David E; Vanner, Stephen J; Yates, Robin M; Bunnett, Nigel W; Edgington-Mitchell, Laura E

TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer.

雪旺细胞中的 TRPV4 激活介导口腔癌的机械性疼痛

Mulpuri Yatendra, Tu Nguyen H, Inoue Kenji, Harden Grace, Nicholson Samuel J, Seenauth Anisa, Huang Yan, Escobar Keylin G, Moayedi Yalda, Bunnett Nigel W, Albertson Donna G, Schmidt Brian L