文献库，生知库 | 链接生命科学的每一步

日期影响因子

Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain

纳米颗粒介导的对降钙素受体样受体持续内体信号传导的拮抗作用，可增强并持久缓解口腔癌疼痛。

期刊:Biomaterials

影响因子:12.9

doi:10.1016/j.biomaterials.2025.123757

Peach, Chloe J; Tu, Nguyen Huu; Lewis, Parker K; Pollard, Rachel E; Sokrat, Badr; Nicholson, Sam; Trevett, Kai; Barrett, Naomi; De Logu, Francesco; Zhu, Jiaqi; Latorre, Rocco; Teng, Shavonne; Therien, Michael J; Jensen, Dane D; Schmidt, Brian L; Bunnett, Nigel W; Pinkerton, Nathalie M

发表日期：2026

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ENDOSOMAL SIGNALING OF PROTEASE-ACTIVATED RECEPTOR-2 AMPLIFIES HISTAMINE-INDUCED PAIN OF IRRITABLE BOWEL SYNDROME

蛋白酶激活受体2的内体信号传导可放大组胺诱发的肠易激综合征疼痛

doi:10.64898/2026.01.30.702691

Jimenez-Vargas, Nestor N; Sokrat, Badr; Gilmour, Daniella A; Pessano, Maria F; Davidson, Steve; Schmidt, Brian L; Reed, David E; Lomax, Alan E; Vanner, Stephen J; Bunnett, Nigel W

肠易激综合征

发表日期：2026

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Pain Signaling by GPCRs and RTKs

GPCR和RTK介导的疼痛信号传导

期刊:Trends in Pharmacological Sciences

影响因子:19.9

doi:10.1016/j.tips.2025.02.002

Schmidt, Brain L; De Logu, Francesco; Nassini, Romina; Geppetti, Pierangelo; Bunnett, Nigel W

GPCR/Calcium/cAMP

发表日期：2025

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A Bacteroides fragilis protease activates host PAR(2) to induce intestinal pain and inflammation.

脆弱拟杆菌蛋白酶激活宿主PAR(2)，诱发肠道疼痛和炎症。

期刊:Cell Host & Microbe

影响因子:18.7

doi:10.1016/j.chom.2025.09.010

Lakemeyer Markus, Latorre Rocco, Blazkova Kristyna, Wood Hannah M, Jensen Dane D, Shakil Nayab, Thomas Scott C, Saxena Deepak, Mulpuri Yatendra, Poolman David, Duran Paz, Keller Laura J, Reed David E, Schmidt Brian L, JimÃ©nez-Vargas NÃ©stor N, Xu Fangxi, Lomax Alan E, Bunnett Nigel W, Bogyo Matthew

发表日期：2025

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Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia

靶向内体中蛋白酶激活受体2的纳米药物可提供持续镇痛作用

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2412687122

Teng, Shavonne L; Latorre, Rocco; Bhansali, Divya; Lewis, Parker K; Pollard, Rachel E; Peach, Chloe J; Sokrat, Badr; Thanigai Arasu, Gokul Sriman; Chiu, Tracy; Duran, Paz; Jimenez-Vargas, Nestor N; Mocherniak, Abby; Bogyo, Matthew; Gaspari, Michael M; Vanner, Stephen J; Pinkerton, Nathalie M; W Leong, Kam; Schmidt, Brian L; Jensen, Dane D; Bunnett, Nigel W

发表日期：2025

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A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation

在小鼠结肠炎症模型中，一种pH敏感型阿片类药物未表现出镇痛耐受性。

期刊:British Journal of Pharmacology

影响因子:7.7

doi:10.1111/bph.17363

Degro, Claudius E; Jiménez-Vargas, Nestor Nivardo; Guzman-Rodriguez, Mabel; Schincariol, Hailey; Tsang, Quentin; Reed, David E; Lomax, Alan E; Bunnett, Nigel W; Stein, Christoph; Vanner, Stephen J

发表日期：2025

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Endophilin A1 and synaptojanin 1-dependent endocytosis of synaptic vesicles in nociceptive spinal circuits maintains postoperative and cancer pain.

脊髓伤害性回路中内吞蛋白 A1 和突触蛋白 1 依赖的突触小泡内吞作用维持着术后疼痛和癌症疼痛

影响因子:5.5

doi:10.1097/j.pain.0000000000003657

Pessano Fialho Maria Fernanda, Thanigai Arasu Gokul Sriman, Chen Shen, Imlach Wendy L, Bunnett Nigel W, Tonello Raquel

发表日期：2025

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Probing the activity of cysteine cathepsins in inflammatory bowel diseases

探究半胱氨酸蛋白酶在炎症性肠病中的活性

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-32489-7

Anderson, Bethany M; Ziegler, Alexander R; Campden, Rhiannon I; Wu, Hongyi; Xu, Bangyan; McQuade, Rachel M; Carbone, Simona E; Poole, Daniel P; Lomax, Alan E; Reed, David E; Vanner, Stephen J; Yates, Robin M; Bunnett, Nigel W; Edgington-Mitchell, Laura E

发表日期：2025

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Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR(2)

从脆弱拟杆菌中鉴定出一种分泌蛋白酶，该蛋白酶通过切割 PAR(2) 诱发肠道疼痛和炎症

doi:10.1101/2025.01.15.633241

Lakemeyer, Markus; Latorre, Rocco; Blazkova, Kristyna; Jensen, Dane; Wood, Hannah M; Shakil, Nayab; Thomas, Scott C; Saxena, Deepak; Mulpuri, Yatendra; Poolman, David; de Haro, Paz Duran; Keller, Laura J; Reed, David E; Schmidt, Brian L; Lomax, Alan E; Bunnett, Nigel W; Bogyo, Matthew

发表日期：2025

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TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer.

雪旺细胞中的 TRPV4 激活介导口腔癌的机械性疼痛

期刊:Frontiers in Pain Research

doi:10.3389/fpain.2025.1532885

Mulpuri Yatendra, Tu Nguyen H, Inoue Kenji, Harden Grace, Nicholson Samuel J, Seenauth Anisa, Huang Yan, Escobar Keylin G, Moayedi Yalda, Bunnett Nigel W, Albertson Donna G, Schmidt Brian L

细胞生物学

发表日期：2025

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