日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus.

选择性抑制 Na v 1.8 对恒河猴镇痛和外周 C 纤维调节的影响

Vardigan Joshua D, Pall Parul S, McDevitt Dillon S, Huang ChienJung, Clements Michelle K, Li Yuxing, Kraus Richard L, Breslin Michael J, Bungard Christopher J, Nemenov Mikhail I, Klukinov Mikhail, Burgey Chritopher S, Layton Mark E, Stachel Shawn J, Lange Henry S, Savitz Alan T, Santarelli Vincent P, Henze Darrell A, Uslaner Jason M

Humanized Na(V)1.8 rats overcome cross-species potency shifts in developing novel Na(V)1.8 inhibitors.

人源化 Na(V)1.8 大鼠克服了开发新型 Na(V)1.8 抑制剂时跨物种效力变化的问题

McDevitt Dillon S, Vardigan Joshua D, Zhou Xiaoping, Rosahl Thomas W, Zhou Heather, Price Eric A, Clements Michelle K, Li Yuxing, Varghese Nissi, Krasowska-Zoladek Alicja, Stachel Shawn J, Breslin Michael J, Burgey Christopher S, Kraus Richard L, Pall Parul S, Henze Darrell A, Santarelli Vincent P

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

呼吸衰竭与膈神经中NaV1.6抑制有关

Klein, Rebecca M; Layton, Mark E; Regan, Hillary; Regan, Christopher P; Li, Yuxing; Filzen, Tracey; Cato, Matt; Clements, Michelle K; Wang, Jixin; Sanoja, Raul; Greshock, Thomas J; Roecker, Anthony J; Pero, Joseph E; Kim, Ron; Burgey, Christopher; John, Christopher T; Wang, Ying-Hong; Bhandari, Neetesh; Struyk, Arie; Kraus, Richard L; Henze, Darrell A; Houghton, Andrea K

Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose

利用转化药代动力学-药效学模型研究NaV1.7抑制剂MK-2075在人体中的有效剂量

Ballard, Jeanine E; Pall, Parul S; Vardigan, Joshua; Zhao, Fuqiang; Holahan, Marie A; Zhou, Xiaoping; Jochnowitz, Nina; Kraus, Richard L; Klein, Rebecca M; Henze, Darrell A; Houghton, Andrea K; Burgey, Christopher S; Gibson, Christopher; Struyk, Arie

Discovery of Arylsulfonamide Na(v)1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

芳基磺酰胺钠(v)1.7抑制剂的发现:体外-体内相关性(IVIVC)、MPO方法及选择性谱的优化

Roecker, Anthony J; Layton, Mark E; Pero, Joseph E; Kelly, Michael J 3rd; Greshock, Thomas J; Kraus, Richard L; Li, Yuxing; Klein, Rebecca; Clements, Michelle; Daley, Christopher; Jovanovska, Aneta; Ballard, Jeanine E; Wang, Deping; Zhao, Fuqiang; Brunskill, Andrew P J; Peng, Xuanjia; Wang, Xiu; Sun, Haiyan; Houghton, Andrea K; Burgey, Christopher S

Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate

应用药代动力学-药效学模型指导体外NaV1.7抑制向非人灵长类动物体内药理反应的转化

Ballard, Jeanine E; Pall, Parul; Vardigan, Joshua; Zhao, Fuqiang; Holahan, Marie A; Kraus, Richard; Li, Yuxing; Henze, Darrell; Houghton, Andrea; Burgey, Christopher S; Gibson, Christopher