Burke Terrence R Jr相关文献与解析，生知库

Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadruple Mutants

对第二代整合酶链转移抑制剂（INSTIs）和在研化合物4d针对一系列整合酶四重突变体的抗病毒活性进行比较分析

期刊:Viruses-Basel

影响因子:3.5

doi:10.3390/v17010121

Smith, Steven J; Zhao, Xue Zhi; Hughes, Stephen H; Burke, Terrence R Jr

微生物学

发表日期：2025

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Pi-pi stacking interactions with viral DNA contribute to the potency of naphthyridine-based HIV-1 integrase inhibitors

π-π堆积相互作用与病毒DNA相互作用，有助于萘啶类HIV-1整合酶抑制剂的效力。

期刊:

影响因子:

doi:10.1093/narmme/ugaf039

Zhao, Xue Zhi; Li, Min; Smith, Steven J; Karbasi, Arvin; Choudhuri, Indrani; Jing, Tao; Lyumkis, Dmitry; Craigie, Robert; Burke, Terrence R Jr

N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants

N-取代双环氨基甲酰吡啶酮：强效抑制耐药性HIV-1整合酶突变体的整合酶链转移抑制剂

期刊:ACS Infectious Diseases

影响因子:3.8

doi:10.1021/acsinfecdis.3c00525

Mahajan, Pankaj S; Smith, Steven J; Li, Min; Craigie, Robert; Hughes, Stephen H; Zhao, Xue Zhi; Burke, Terrence R Jr

Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging.

提高结直肠癌手术的精准度：开发靶向 LGR5 的 RSPO1 肽模拟物作为术中荧光分子成像的对比剂

期刊:Cell Cycle

影响因子:3.4

doi:10.1080/15384101.2024.2364578

Parasido Erika, Ribeiro Patricia, Chingle Ramesh M, Rohwetter Thomas, Gupta Nikita, Avetian George, Bladelli Elisa, Pierobon Mariaelena, Chen Yu, Tang Qinggong, Schnermann Martin, Rodriguez Olga, Robbins David, Burke Terrence R Jr, Albanese Chris, Ihemelandu Chukwuemeka

Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component

利用共价激酶结合组分，通过二价方法增强polo样激酶1 polo盒结构域结合配体的亲和力

期刊:RSC Chemical Biology

影响因子:3.1

doi:10.1039/d4cb00031e

Tsuji, Kohei; Tamamura, Hirokazu; Burke, Terrence R Jr

信号转导

发表日期：2024

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Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3

将基于荧光恢复的 Polo 样激酶 1 结合分析法应用于 Polo 样激酶 2 和 Polo 样激酶 3

期刊:Biological & Pharmaceutical Bulletin

影响因子:1.7

doi:10.1248/bpb.b24-00189

Tsuji, Kohei; Tamamura, Hirokazu; Burke, Terrence R Jr

信号转导

发表日期：2024

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Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants

HIV-1整合酶对多替拉韦产生耐药性的机制以及对耐药变异株的有效抑制

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.adg5953

Li, Min; Oliveira Passos, Dario; Shan, Zelin; Smith, Steven J; Sun, Qinfang; Biswas, Avik; Choudhuri, Indrani; Strutzenberg, Timothy S; Haldane, Allan; Deng, Nanjie; Li, Zhaoyang; Zhao, Xue Zhi; Briganti, Lorenzo; Kvaratskhelia, Mamuka; Burke, Terrence R Jr; Levy, Ronald M; Hughes, Stephen H; Craigie, Robert; Lyumkis, Dmitry

Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir

HIV-1整合酶链转移抑制剂多替拉韦、比克替拉韦和卡博特韦共有的关键吡啶酮羧酸前体的合成方法

期刊:Organic Process Research & Development

影响因子:3.5

doi:10.1021/acs.oprd.3c00063

Mahajan, Pankaj S; Burke, Terrence R Jr

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification

通过肟类化合物多样化鉴定可同时作用于DNA、蛋白质和催化结合位点的多齿酪氨酰-DNA磷酸二酯酶1 (TDP1) 抑制剂

期刊:RSC Chemical Biology

影响因子:3.1

doi:10.1039/d2cb00230b

Zhao, Xue Zhi; Wang, Wenjie; Lountos, George T; Kiselev, Evgeny; Tropea, Joseph E; Needle, Danielle; Pommier, Yves; Burke, Terrence R Jr

发表日期：2023

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Potent Î²-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen.

通过虚拟筛选鉴定出强效β-内酰胺类酪氨酰-DNA磷酸二酯酶1抑制剂

Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadruple Mutants

对第二代整合酶链转移抑制剂（INSTIs）和在研化合物4d针对一系列整合酶四重突变体的抗病毒活性进行比较分析

Pi-pi stacking interactions with viral DNA contribute to the potency of naphthyridine-based HIV-1 integrase inhibitors

π-π堆积相互作用与病毒DNA相互作用，有助于萘啶类HIV-1整合酶抑制剂的效力。

N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants

N-取代双环氨基甲酰吡啶酮：强效抑制耐药性HIV-1整合酶突变体的整合酶链转移抑制剂

Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging.

提高结直肠癌手术的精准度：开发靶向 LGR5 的 RSPO1 肽模拟物作为术中荧光分子成像的对比剂

Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component

利用共价激酶结合组分，通过二价方法增强polo样激酶1 polo盒结构域结合配体的亲和力

Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3

将基于荧光恢复的 Polo 样激酶 1 结合分析法应用于 Polo 样激酶 2 和 Polo 样激酶 3

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants

HIV-1整合酶对多替拉韦产生耐药性的机制以及对耐药变异株的有效抑制

Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir

HIV-1整合酶链转移抑制剂多替拉韦、比克替拉韦和卡博特韦共有的关键吡啶酮羧酸前体的合成方法

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification

通过肟类化合物多样化鉴定可同时作用于DNA、蛋白质和催化结合位点的多齿酪氨酰-DNA磷酸二酯酶1 (TDP1) 抑制剂