日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In silico discovery and mechanistic profiling of STING agonists engaging the transmembrane domain

利用计算机模拟发现和机制分析与跨膜结构域结合的STING激动剂

Junaid, Ahmad; Pandey, Uddav; Ward, Janine; Meghani, Nilesh; Miller, Shannon; Negron, Austin; Ryter, Kendal; Burkhart, David; Mizuno, Nobuyu; DeFilippis, Victor R; Rasheed, Omer

Encapsulation of the lipidated TLR7/8 agonist INI-4001 into ionic liposomes impacts H7 influenza antigen-specific immune responses

将脂化 TLR7/8 激动剂 INI-4001 封装到离子脂质体中会影响 H7 流感抗原特异性免疫反应。

Mehradnia, Fatemeh; Amin, Hardik; Ferrini, Maria E; Partlow, Haley; Borgogna, Timothy; Dachavaram, Soma Shekar; T Ryter, Kendal; Bazin, Hélène G; Evans, Jay T; Burkhart, David J; DeBuysscher, Blair; Abdelwahab, Walid M

The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine

TLR7/8激动剂INI-4001可增强波瓦桑病毒样颗粒疫苗的免疫原性。

Crawford, Michael W; Abdelwahab, Walid M; Siram, Karthik; Parkins, Christopher J; Harrison, Henry F; Stone, E Taylor; Osman, Samantha R; Schweitzer, Dillon; Burkhart, David J; Pinto, Amelia K; Brien, James D; Smith, Jessica L; Hirsch, Alec J

A cationic liposome-formulated Toll Like Receptor (TLR)7/8 agonist enhances the efficacy of a vaccine against fentanyl toxicity

阳离子脂质体包裹的 Toll 样受体 (TLR)7/8 激动剂可增强疫苗对芬太尼中毒的疗效

Hamid, Fatima A; Le, Nguyet-Minh Nguyen; Song, Daihyun; Amin, Hardik; Hicks, Linda; Bird, Sophia; Siram, Karthik; Hoppe, Brooke; Demeler, Borries; Evans, Jay T; Burkhart, David; Pravetoni, Marco

Characterization of a Novel Transmembrane Activating STING Agonist using Genetically Humanized Mice.

利用基因人源化小鼠对新型跨膜激活STING激动剂进行表征

Mizuno Nobuyo, Abraham Jinu, Jimenez-Perez Kevin, Rose Ian, Springgay Laura, Boehm Dylan, Ando Takeshi, Streblow Daniel, Ward Janine, Miller Shannon, Pandey Uddav, Junaid Ahmad, Joyner David, Muir Roshell, Haddad Elias K, Burkhart David, Rasheed Omer, DeFilippis Victor R

Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses.

利用二氧化硅纳米颗粒共同递送新型脂化 TLR7/8 激动剂和基于血凝素的流感抗原可促进增强免疫反应

Abdelwahab Walid M, Auclair Sarah, Borgogna Timothy, Siram Karthik, Riffey Alexander, Bazin Hélène G, Cottam Howard B, Hayashi Tomoko, Evans Jay T, Burkhart David J

Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists.

对芳基海藻糖Mincle激动剂的区域化学和脂化进行系统评价

Riel Asia Marie S, Rungelrath Viktoria, Elwaie Tamer A, Rasheed Omer K, Hicks Linda, Ettenger George, You Dai-Chi, Smith Mira, Buhl Cassandra, Abdelwahab Walid, Miller Shannon M, Smith Alyson J, Burkhart David, Evans Jay T, Ryter Kendal T

Adjuvanted Vaccine Induces Functional Antibodies against Pseudomonas aeruginosa Filamentous Bacteriophages

佐剂疫苗可诱导产生针对铜绿假单胞菌丝状噬菌体的功能性抗体

Román-Cruz, Valery C; Miller, Shannon M; Schoener, Roman A; Lukasiewicz, Chase; Schmidt, Amelia K; DeBuysscher, Blair L; Burkhart, David; Secor, Patrick R; Evans, Jay T

Vaccination with ancestral SARS-CoV-2 spike adjuvanted with TLR agonists provides cross-protection against XBB.1.

用 TLR 激动剂佐剂的祖先 SARS-CoV-2 刺突蛋白进行疫苗接种可提供针对 XBB.1 的交叉保护

Lathrop Stephanie K, Clark Jordan J, Siram Karthik, Andreata-Santos Robert, Yong Jeremy, Tee Rebekah D, Davison Clara J, Singh Gagandeep, Burkhart David, Krammer Florian, Evans Jay T

Self-Adjuvanting TLR7/8 Agonist and Fentanyl Hapten Co-Conjugate Achieves Enhanced Protection against Fentanyl Challenge

自佐剂TLR7/8激动剂与芬太尼半抗原共轭物可增强对芬太尼攻击的保护作用

Powers, Noah; Massena, Casey; Crouse, Bethany; Smith, Mira; Hicks, Linda; Evans, Jay T; Miller, Shannon; Pravetoni, Marco; Burkhart, David