日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections

基于氟化异吲哚啉酮的葡萄糖基神经酰胺合成酶抑制剂的低剂量人体预测

Loughran, H Marie; Schirripa, Kathy M; Roecker, Anthony J; Breslin, Michael J; Tong, Ling; Fillgrove, Kerry L; Kuo, Yuhsin; Bleasby, Kelly; Collier, Hannah; Altman, Michael D; Ford, Melissa C; Newman, Justin A; Drolet, Robert E; Cosden, Mali; Jinn, Sarah; Flick, Rosemarie B; Liu, Xiaomei; Minnick, Christina; Watt, Marla L; Lemaire, Wei; Burlein, Christine; Adam, Gregory C; Austin, Lauren A; Marcus, Jacob N; Smith, Sean M; Fraley, Mark E

Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships

广谱抗疱疹病毒噁唑烷酮酰胺衍生物的发现及其构效关系

Plotkin, Michael A; Labroli, Marc; Schubert, Jeffrey; Shaw, Anthony; Schlegel, Kelly-Ann S; Berger, Richard; Cooke, Andrew J; Hayes, Robert P; Armacost, Kira A; Kinek, Keith; Krosky, Paula; Burlein, Christine; Meng, Shi; DiNunzio, Edward; Murray, Edward M; Agrawal, Sony; Madeira, Maria; Flattery, Amy; Yao, Huifang; Leithead, Andrew; Rose, William A 2nd; Cox, Christopher; Tellers, David M; McKenna, Philip M; Raheem, Izzat

Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor.

透析患者体内白细胞介素-16水平升高,但白细胞介素-16并非心血管疾病的危险因素

Brösecke Frederic, Pfau Anja, Ermer Theresa, Dein Terra Mota Ribeiro Ana Beatriz, Rubenbauer Lisa, Rao Veena S, Burlein Sarah, Genser Bernd, Reichel Martin, Aronson Peter S, Coca Steven, Knauf Felix

Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling

新型泛冠状病毒 3CL 蛋白酶抑制剂 MK-7845:生物学和药理学分析

Nadine Alvarez, Gregory C Adam, John A Howe, Vijeta Sharma, Matthew D Zimmerman, Enriko Dolgov, Risha Rasheed, Fatima Nizar, Khushboo Sahay, Andrew M Nelson, Steven Park, Xiaoyan Zhou, Christine Burlein, John F Fay, Daniel V Iwamoto, Carolyn M Bahnck-Teets, Krista L Getty, Shih Lin Goh, Imad Salhab,

Screening for Psychosocial Distress: A Brief Review with Implications for Oncology Nursing

心理社会困扰筛查:简要回顾及其对肿瘤护理的启示

Fitch, Margaret I; Nicoll, Irene; Burlein-Hall, Stephanie

Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease

吡唑脲类药物作为低剂量、可穿透血脑屏障的中枢神经系统葡糖基神经酰胺合成酶抑制剂,用于治疗帕金森病

Roecker, Anthony J; Schirripa, Kathy M; Loughran, H Marie; Tong, Ling; Liang, Tao; Fillgrove, Kerry L; Kuo, Yuhsin; Bleasby, Kelly; Collier, Hannah; Altman, Michael D; Ford, Melissa C; Drolet, Robert E; Cosden, Mali; Jinn, Sarah; Hatcher, Nathan G; Yao, Lihang; Kandebo, Monika; Vardigan, Joshua D; Flick, Rosemarie B; Liu, Xiaomei; Minnick, Christina; Price, Laura A; Watt, Marla L; Lemaire, Wei; Burlein, Christine; Adam, Gregory C; Austin, Lauren A; Marcus, Jacob N; Smith, Sean M; Fraley, Mark E

Dominant negative mutation in oxalate transporter SLC26A6 associated with enteric hyperoxaluria and nephrolithiasis

草酸转运蛋白 SLC26A6 的显性负突变与肠道高草酸尿症和肾结石有关

Nicolas Cornière, R Brent Thomson, Stéphanie Thauvin, Bruno O Villoutreix, Sophie Karp, Diane W Dynia, Sarah Burlein, Lennart Brinkmann, Alaa Badreddine, Aurélie Dechaume, Mehdi Derhourhi, Emmanuelle Durand, Emmanuel Vaillant, Philippe Froguel, Régine Chambrey, Peter S Aronson, Amélie Bonnefond, Dom

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.

对延伸疱疹病毒聚合酶中非核苷类抑制剂的结构理解

Hayes Robert P, Heo Mee Ra, Mason Mark, Reid John, Burlein Christine, Armacost Kira A, Tellers David M, Raheem Izzat, Shaw Anthony W, Murray Edward, McKenna Philip M, Abeywickrema Pravien, Sharma Sujata, Soisson Stephen M, Klein Daniel

A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy

一种新型葡萄糖神经酰胺合酶抑制剂可减轻突触核蛋白病临床前模型中的 α 突触核蛋白病理和溶酶体功能障碍

Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A Gretzula, Monika Kandebo, Dawn Toolan, Nathan G Hatcher, Lei Ma, Wei Lemaire, Gregory C Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L Watt, James Mulhearn, Mark Fraley, Robert E Drolet, Jacob N Marcus, Sean M Smith

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

重新定义组蛋白去乙酰化酶抑制剂药效团:高效且无锌辅因子相互作用

Beshore, Douglas C; Adam, Gregory C; Barnard, Richard J O; Burlein, Christine; Gallicchio, Steven N; Holloway, M Katharine; Krosky, Daniel; Lemaire, Wei; Myers, Robert W; Patel, Sangita; Plotkin, Michael A; Powell, David A; Rada, Vanessa; Cox, Christopher D; Coleman, Paul J; Klein, Daniel J; Wolkenberg, Scott E