日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.

热量限制通过重塑碳水化合物和脂质代谢、改变过氧化物酶体和线粒体功能以及推迟凋亡和脂质坏死等受调控细胞死亡方式的发生,来延缓酵母的自然衰老

Arlia-Ciommo Anthony, Leonov Anna, Beach Adam, Richard Vincent R, Bourque Simon D, Burstein Michelle T, Kyryakov Pavlo, Gomez-Perez Alejandra, Koupaki Olivia, Feldman Rachel, Titorenko Vladimir I

Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms.

对驱动寿命调节机制演化的兴奋性选择力量假说进行实证验证

Gomez-Perez Alejandra, Kyryakov Pavlo, Burstein Michelle T, Asbah Nimara, Noohi Forough, Iouk Tania, Titorenko Vladimir I

Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.

只有在酵母生命周期的某些关键时期添加石胆酸,才能延长酵母的寿命

Burstein Michelle T, Kyryakov Pavlo, Beach Adam, Richard Vincent R, Koupaki Olivia, Gomez-Perez Alejandra, Leonov Anna, Levy Sean, Noohi Forough, Titorenko Vladimir I

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.

化学遗传筛选发现石胆酸是一种抗衰老化合物,它通过调节管家长寿保证过程,以不依赖于 TOR 的方式延长酵母的寿命

Goldberg Alexander A, Richard Vincent R, Kyryakov Pavlo, Bourque Simon D, Beach Adam, Burstein Michelle T, Glebov Anastasia, Koupaki Olivia, Boukh-Viner Tatiana, Gregg Christopher, Juneau Mylène, English Ann M, Thomas David Y, Titorenko Vladimir I