日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family

1q31.3 染色体区域内的常见单倍型决定了整个补体因子 H 蛋白家族的系统浓度。

Veuskens, Bert R J; van Rossum, Mara; Cattenstart, Emi; Brouwer, Mieke C; van Mierlo, Gerard; Geissler, Judy; van Leeuwen, Karin; Liu, Jin; Anstadt, Robert A; Richards, Burt T; Hageman, Gregory S; Kuijpers, Taco W; Toonen, Erik J M; Pouw, Richard B

Dissecting the biological complexity of age-related macular degeneration: Is it one disease, multiple separate diseases, or a spectrum?

剖析年龄相关性黄斑变性的生物学复杂性:它是一种疾病、多种独立的疾病,还是一个疾病谱?

Miller, Jason M L; Thompson, Benjamin R; Handa, James T; Luthert, Philip; Chakravarthy, Usha; Csaky, Karl G; Bird, Alan; Young, Benjamin K; Iyengar, Sudha K; Baek, Jiwon; Zouache, Moussa A; Richards, Burt T; Hageman, Gregory S; Rodrigues, Gerry; Bharti, Kapil; Flannery, John G; Gorin, Michael B; Bowes Rickman, Catherine

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration

补充视网膜色素上皮中的 IRAK-M 表达可减轻外层视网膜变性

Jian Liu, David A Copland, Alison J Clare, Mathias Gorski, Burt T Richards, Louis Scott, Sofia Theodoropoulou, Ursula Greferath, Katherine Cox, Gongyu Shi, Oliver H Bell, Kepeng Ou, Jenna Le Brun Powell, Jiahui Wu, Luis Martinez Robles, Yingxin Li, Lindsay B Nicholson, Peter J Coffey, Erica L Fletch

Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

血清和玻璃体液中 HtrA1 蛋白的水平与 10q26 位点年龄相关性黄斑变性的遗传风险无关

Brandi L Williams, Moussa A Zouache, Nathan A Seager, Chris M Pappas, Jin Liu, Robert A Anstadt, William C Hubbard, Julie Thomas, Jill L Hageman, Jennifer Mohler, Burt T Richards, Gregory S Hageman

Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

补充视网膜色素上皮细胞中与年龄相关的IRAK-M表达下降可减轻外层视网膜变性。

Liu, Jian; Copland, David A; Clare, Alison J; Gorski, Mathias; Richards, Burt T; Scott, Louis; Theodoropoulou, Sofia; Greferath, Ursula; Cox, Katherine; Bell, Oliver H; Ou, Kepeng; Powell, Jenna Le Brun; Wu, Jiahui; Robles, Luis Martinez; Li, Yingxin; Nicholson, Lindsay B; Coffey, Peter J; Fletcher, Erica L; Guymer, Robyn; Radeke, Monte J; Heid, Iris M; Hageman, Gregory S; Chan, Ying Kai; Dick, Andrew D

Role of Erythropoietin Receptor Signaling in Macrophages or Choroidal Endothelial Cells in Choroidal Neovascularization

巨噬细胞或脉络膜内皮细胞中的促红细胞生成素受体信号在脉络膜新生血管中的作用

Aniket Ramshekar, Colin A Bretz, Eric Kunz, Thaonhi Cung, Burt T Richards, Gregory J Stoddard, Gregory S Hageman, Brahim Chaqour, M Elizabeth Hartnett

Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci

保护性1q32染色体单倍型可降低与CFH-CFHR5和ARMS2/HTRA1基因座相关的年龄相关性黄斑变性的风险。

Pappas, Chris M; Zouache, Moussa A; Matthews, Stacie; Faust, Caitlin D; Hageman, Jill L; Williams, Brandi L; Richards, Burt T; Hageman, Gregory S

Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10

由1号和10号染色体上的风险多态性驱动的年龄相关性黄斑变性,其黄斑视网膜厚度存在显著差异。

Zouache, Moussa A; Bennion, Alex; Hageman, Jill L; Pappas, Christian; Richards, Burt T; Hageman, Gregory S

Intra-Target Microdosing (ITM): A Novel Drug Development Approach Aimed at Enabling Safer and Earlier Translation of Biological Insights Into Human Testing

靶内微剂量给药(ITM):一种旨在更安全、更早地将生物学见解转化为人体试验的新型药物开发方法

Burt, T; Noveck, R J; MacLeod, D B; Layton, A T; Rowland, M; Lappin, G

Pharmacometabolomics in Early-Phase Clinical Development

药物代谢组学在早期临床开发中的应用

Burt, T; Nandal, S