日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization

单次注射免疫后,恒河猴V2顶端敲入小鼠模型迅速获得HIV-1中和广度

Ghosh, Amrit Raj; Habib, Rumi; Mishra, Nitesh; Roark, Ryan S; Akauliya, Madhav; Albowaidey, Ali A; Allen, Joel D; Amereh, Khaled; Avillion, Gabriel; Bottermann, Maria; Liang, Bo; Chaudhary, Namit; Callaghan, Sean; Dye, Jonathan; Li, Xuduo; Ellis-Pugh, Jordan R; Roy Chowdhury, Rohan; James, Nicole E; Liu, Xiaotie; Maiorino, Laura; Villavicencio, Paula M; Nedellec, Rebecca; Oberoi, Prabhgun; Sowers, Kirsten J; Park, Younghoon; Prum, Thavaleak; Rodriguez, Linette; Ssozi, Maria; Torres, Jonathan L; Walsh, Agnes A; Warner, John E; Weldon, Stephanie R; Xu, Liling; Wiehe, Kevin; Crispin, Max; Ward, Andrew B; Nair, Usha; Hahn, Beatrice H; Burton, Dennis R; Shapiro, Lawrence; Kwong, Peter D; Irvine, Darrell J; Andrabi, Raiees; Shaw, George M; Batista, Facundo D

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Env抗体共同进化表明B细胞启动是HIV V2顶端广泛中和抗体发展的主要瓶颈。

Habib Rumi, Roark Ryan S, Li Hui, Connell Andrew Jesse, Hogarty Michael P, Wagh Kshitij, Wang Shuyi, Marchitto Lorie, Skelly Ashwin N, Carey John W, Sowers Kirsten J, Ayyanathan Kasirajan, Plante Samantha J, Bibollet-Ruche Frederic, Park Younghoon, Agostino Colby J, Singh Ajay, Martella Christian L, Lewis Emily, Rando Juliette M, Chohan Neha, Lora Jinery, Ding Wenge, Campion Mary S, Zhao Chengyan, Liu Weimin, Li Yingying, Li Xuduo, Liang Bo, Chowdhury Rohan Roy, Amereh Khaled, Van Itallie Elizabeth, Sheng Zizhang, Ghosh Amrit R, Bar Katharine J, Williams Wilton B, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Cain Derek W, Lewis Mark G, Batista Facundo D, Burton Dennis R, Andrabi Raiees, Kulp Daniel W, Haynes Barton F, Korber Bette, Shapiro Lawrence, Kwong Peter D, Hahn Beatrice H, Shaw George M

Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes

利用深度学习构建 PfCSP 表位的空间阵列

Wu, Nelson R; Castro, Karla M; Beutler, Nathan; Lee, Wen-Hsin; Raghavan, Sai S R; Martin, Gregory M; Jain, Monika; Agrawal, Sashank; Liguori, Alessia; Kalyuzhniy, Oleksandr; Skog, Patrick D; Terada, Sierra; Lai, Yen-Chung; Ndihokubwayo, Justin; Lu, Danny; Eskandarzadeh, Saman; Alavi, Nushin; Phelps, Nicole; Tingle, Ryan; Youhanna, John E; Amirzehni, Sonya; Rogers, Thomas F; Burton, Dennis R; Wilson, Ian A; Ward, Andrew B; Correia, Bruno E; Schief, William R

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.

早期克隆优势决定了 HIV 血清中和的广泛进程。

Liang Bo, Zhu Yuxin, Roark Ryan S, Li Xuduo, Mishra Nitesh, Martella Christian L, Vo Anh L, Giese Gabriella, Huang Qin, Biju Andrea, Tjio Lifei, Chowdhury Rohan Roy, Oberoi Prabhgun, Amereh Khaled, Wani Areeba A, Zhang Yuexiu, Andrabi Sharaf, Sekar Tharunika V, Somanathan Anjali, Kassab Muzaffer, Nedellec Rebecca, Callaghan Sean, Avillion Gabriel, Lewis Mark G, Sackett Sara Dutton, Skelly Ashwin N, Bibollet-Ruche Frederic, Shapiro Lawrence, Sheng Zizhang, Briney Bryan, Hahn Beatrice H, Burton Dennis R, Irvine Darrell J, Kwong Peter D, Shaw George M, Andrabi Raiees

Heterologous betacoronavirus spike immunization in nonhuman primates elicits cross-reactive antibodies that neutralize both sarbeco- and merbecoviruses.

在非人灵长类动物中进行异源β冠状病毒刺突蛋白免疫可诱导产生交叉反应抗体,该抗体可中和沙贝病毒和默贝病毒。

Dueker Katharina, Capozzola Tazio, Feng Ziqi, Lin Ryan N, Hurtado Jonathan, Bangaru Sandhya, Yuan Meng, Beutler Nathan, Garcia Elijah, He Wan-Ting, Callaghan Sean, Avillion Gabriel, Vo Lina, Li Xuduo, Torres Jonathan L, Musharrafieh Rami, Song Ge, Mishra Nitesh, Sharma Pragati, Yong Peter, Anzanello Fabio, Kaczmarek-Michaels Kasia, Ben-Akiva Elana, Silva Murillo, Melo Mariane, Makhdoomi Muzamil, Westfall-Gomez Ethan, Rinaldi William, Ferguson Melissa, Safonova Yana, Crotty Shane, Irvine Darrell J, Rogers Thomas, Ward Andrew B, Briney Bryan, Wilson Ian A, Burton Dennis R, Andrabi Raiees

Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody-viral glycoprotein complexes.

微流控技术与电子显微镜相结合,可快速、高通量地绘制抗体-病毒糖蛋白复合物图谱

Sewall Leigh M, de Paiva Froes Rocha Rebeca, Gibson Grace, Louie Michelle, Xie Zhenfei, Bangaru Sandhya, Tran Andy S, Ozorowski Gabriel, Mohanty Subhasis, Beutler Nathan, Rogers Thomas F, Burton Dennis R, Shaw Albert C, Batista Facundo D, Chocarro Ruiz Blanca, Torrents de la Peña Alba, Ward Andrew B

Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development.

功能强大且持续时间长的生发中心 T 滤泡辅助细胞反应与增强的中和抗体生成有关。

Marina-Zárate Ester, Sutton Henry J, Lopez Paul G, Altheide Tasha K, Bick Michael, Burton Iszac, Ben-Akiva Elana, Kaczmarek Michaels Katarzyna, Hyacinth Kesha, Healy Brandon S, Lim Deuk, Hangartner Lars, Burton Dennis R, Carnathan Diane G, Silvestri Guido, Schief William R, Irvine Darrell J, Crotty Shane

Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2

普通感冒病毒印迹可诱导针对 SARS-CoV-2 S2 的广谱中和抗体反应

Changrob, Siriruk; Yasuhara, Atsuhiro; Park, Suncheol; Bangaru, Sandhya; Li, Lei; Troxell, Chloe A; Halfmann, Peter J; Erickson, Steven A; Catanzaro, Nicholas J; Yuan, Meng; Zhou, Panpan; Huang, Min; Wilbanks, G Dewey; McGrath, Joshua J C; Singh, Gagandeep; Nelson, Sean A; Fu, Yanbin; Zheng, Nai-Ying; Carayannopoulos, Sofia M; Dugan, Haley L; Shaw, Dustin G; Stamper, Christopher T; Madariaga, Maria Lucia L; Krammer, Florian; Andrabi, Raiees; Burton, Dennis R; Ward, Andrew B; Wilson, Ian A; Kawaoka, Yoshihiro; Wilson, Patrick C

Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope

HIV包膜蛋白背景下调控抗体FcγR信号传导和效应功能的分子参数

Bick, Michael V; Puig, Eduard; Beauparlant, David; Nedellec, Rebecca; Burton, Iszac; Ardaghi, Keihvan; Zalunardo, Thea R; Bastidas, Raiza; Li, Xuduo; Guenaga, Javier; Lee, Wen-Hsin; Wyatt, Richard; Zhu, Wenwen; Crispin, Max; Ozorowski, Gabriel; Ward, Andrew B; Burton, Dennis R; Hangartner, Lars

mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model

利用mRNA递送基于环子孢子蛋白表位的疟疾疫苗可在小鼠模型中诱导保护作用

Wu, Nelson R; Beutler, Nathan; Hu, Xiaozhen; Skog, Patrick D; Liguori, Alessia; Flores-Garcia, Yevel; Maiorino, Laura; Terada, Sierra; Lu, Danny; Lai, Yen-Chung; Ndihokubwayo, Justin; Schiffner, Torben; Cottrell, Christopher A; Eskandarzadeh, Saman; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Tingle, Ryan; Hodges, Sam; Youhanna, John E; Amirzehni, Sonya; Irvine, Darrell J; Himansu, Sunny; Zavala, Fidel; Rogers, Thomas F; Burton, Dennis R; Schief, William R