日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response

IGH::FENDRR 和特定的 KRAS 突变定义了一种新型的 B 细胞急性淋巴细胞白血病 (B-ALL) 分子亚型,该亚型对化疗反应较差。

Bendig, Sonja; Hartmann, Alina M; Wessels, Wiebke; Beder, Thomas; Kim, Rathana; Passet, Marie; Gao, Qingsong; Wolgast, Nadine; Horns, Johanna M; Alves Santos, Leonardo; Iben, Katharina; Steffen, Fabio D; Cantoni, Loredana; Kehden, Britta; Chitadze, Guranda; Künstner, Axel; Busch, Hauke; Bornhauser, Beat; Bourquin, Jean-Pierre; Leguay, Thibaut Tl; Boissel, Nicolas; Gökbuget, Nicola; Iacobucci, Ilaria; Mullighan, Charles G; Clappier, Emmanuelle; Baldus, Claudia D; Brüggemann, Monika; Bastian, Lorenz

Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease.

结肠空间单细胞蛋白质组学和鼠模型将线粒体功能障碍与克罗恩病中分泌二聚体 IgA 的浆细胞缺乏联系起来。

Raschdorf Annika, de Almeida Larissa Nogueira, Solbach Philipp, Kirstein Martha M, Marquardt Jens U, Schmelter Franziska, Günther Ulrich L, Schlichting Heidi, Hicken Maren, Christiansen Lea, Wiestler Miriam, Tews Hauke C, Bettenworth Dominik, Peipp Matthias, Valerius Thomas, Ragab Mohab, Sauer Thorben, Gemoll Timo, Ehlers Marc, Rosenstiel Philip, Manz Rudolf A, Künstner Axel, Busch Hauke, Sina Christian, Derer Stefanie

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

气道上皮细胞中白细胞介素 6 基因的免疫训练是哮喘急性发作的核心

Lunding, Lars P; Weckmann, Markus; Zissler, Ulrich M; Jakwerth, Constanze; Bodenstein-Sgró, Rebecca; Webering, Sina; Vock, Christina; Ehlers, Johanna C; Fernandez Ceballos, Romina A M; Nemani, Sai Sneha Priya; Reddy, Karosham Diren; Oliver, Brian George G; Vermeulen, Cornelis J; van de Berge, Maarten; Ober, Carole; Künstner, Axel; Busch, Hauke; König, Inke; Garbers, Christoph; Schmidt-Weber, Carsten B; Nold, Marcel F; Yildirim, Ali Önder; Nold-Petry, Claudia A; Orinska, Zane; Bahmer, Thomas; Heyckendorf, Jan; Hansen, Gesine; von Mutius, Erika; Rabe, Klaus F; Dittrich, Anna-Maria; Schaub, Bianca; Brinkmann, Folke; Kopp, Matthias V; Wegmann, Michael

Adenosine Pathway Activation Defines Genetically Linked Immunosuppressive Subtypes in Solid Tumor Brain Metastases

腺苷通路激活定义了实体瘤脑转移中具有遗传关联的免疫抑制亚型

Bauer, Arthur; Arndt, Annette; Reichenbach, Luisa; Gebauer, Niklas; Müller, Matthias; Neumann, Christian; Schulz, Chris; Steinestel, Konrad; Heller, Raban; Chteinberg, Emil; Busch, Hauke; Riecke, Armin; Künstner, Axel; Witte, Hanno

Exploring the underlying gene expression profiles of differences of sex development phenotypes through transcriptome analysis

通过转录组分析探索性别发育表型差异的潜在基因表达谱

Fabbri-Scallet, Helena; Calonga-Solís, Verónica; Guerra-Júnior, Gil; de Mello, Maricilda Palandi; Maciel-Guerra, Andréa Trevas; Miranda, Márcio Lopes; Antolini-Tavares, Arthur; Busch, Hauke; Künstner, Axel; Werner, Ralf; Hiort, Olaf

Target Class Repurposing Across Membrane Transporter Families Provides Privileged Ligands to Address Specific and Undruggable Pharmacological Targets

跨膜转运蛋白家族的靶向类别重定位提供了针对特定和不可成药药理靶点的特有配体

Rafehi, Muhammad; Tägl, Franziska; Arlt, Nike Sophia; Neif, Maria; Stefan, Katja; Ismail Al-Khalil, Wouroud; Busch, Hauke; Möller, Marius; König, Jörg; Namasivayam, Vigneshwaran; Stefan, Sven Marcel

Multi-Omics Characterization of a KIF1C Structural Variant in a Patient with a Complex Movement Disorder Partially Responsive to Deep Brain Stimulation

对一名患有复杂运动障碍且对深部脑刺激部分有效的患者进行KIF1C结构变异的多组学表征

Thomsen, Mirja; Borsche, Max; Yépez, Vicente A; Rasche, Dirk; Ullrich, Kristian K; Tadic, Vera; Abdelwakeel, Saad M; Busch, Hauke; Franzenburg, Sören; Trinh, Joanne; Klein, Christine; Lohmann, Katja; Brüggemann, Norbert

Ruxolitinib mediated paradoxical JAK2 hyperphosphorylation is due to the protection of activation loop tyrosines from phosphatases.

鲁索替尼介导的 JAK2 反常过度磷酸化是由于激活环酪氨酸免受磷酸酶的侵害所致

Gorantla Sivahari P, Oelschläger Lorenz, Prince Gerin, Osius Jasmin, Kolluri Suresh Babu, Maluje Yamil, Fähnrich Anke, Ernst Nancy, Barbosa Gulde Alanis, Ludwig Ralf Joachim, Gemoll Timo, Fliedner Stephanie, Walter Wencke, Haferlach Torsten, Gebauer Niklas, Busch Hauke, Duyster Justus, von Bubnoff Nikolas

Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

新石器时代IL23R相关保护机制传入现代欧洲人体内,以抵抗慢性炎症性肠病

Krause-Kyora, Ben; da Silva, Nicolas Antonio; Kaplan, Elif; Kolbe, Daniel; Wohlers, Inken; Busch, Hauke; Ellinghaus, David; Caliebe, Amke; Sezgin, Efe; Nebel, Almut; Schreiber, Stefan

Molecular profiling of primary renal marginal zone lymphoma reveals overlapping features with extranodal marginal zone lymphoma

原发性肾边缘区淋巴瘤的分子谱分析显示其与结外边缘区淋巴瘤存在重叠特征。

Künstner, Axel; von Kopylow, Vera; Lohneis, Philipp; Kümmel, Matthias; Witte, Hanno M; Bernard, Veronica; Stölting, Stephanie; Kusch, Kathrin; Gorantla, Sivahari; Krokowski, Manuela; von Bubnoff, Nikolas; Merz, Hartmut; Busch, Hauke; Feller, Alfred C; Gebauer, Niklas