日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury

开发一种针对转录因子 Brachyury 的小分子下调剂

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202316496
Chase, Davis H; Bebenek, Adrian M; Nie, Pengju; Jaime-Figueroa, Saul; Butrin, Arseniy; Castro, Danielle A; Hines, John; Linhares, Brian M; Crews, Craig M
发表日期：2024
文献求助 收藏

Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S,4 S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

(3 S,4 S)-3-氨基-4-氟环戊烯羧酸使人类鸟氨酸氨基转移酶失活的结构和机制基础

期刊:Molecules
影响因子:4.2
doi:10.3390/molecules28031133
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio M Ferreira, Peter F Doubleday, Daniel H Grass, Wei Zhu, Neil L Kelleher, Graham R Moran, Dali Liu, Richard B Silverman
Human
发表日期：2023
文献求助 收藏

Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

(3S,4R)-3-氨基-4-(二氟甲基)环戊-1-烯-1-羧酸的合理设计、合成及机理：采用二次去质子化策略提高人鸟氨酸氨基转移酶相对于GABA氨基转移酶的选择性

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.2c00924
Zhu, Wei; Butrin, Arseniy; Melani, Rafael D; Doubleday, Peter F; Ferreira, Glaucio Monteiro; Tavares, Mauricio T; Habeeb Mohammad, Thahani S; Beaupre, Brett A; Kelleher, Neil L; Moran, Graham R; Liu, Dali; Silverman, Richard B
Human
发表日期：2022
文献求助 收藏

Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase

测定人鸟氨酸氨基转移酶的pH依赖性、底物特异性和替代底物的周转率

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2022.101969
Butrin, Arseniy; Butrin, Anastassiya; Wawrzak, Zdzislaw; Moran, Graham R; Liu, Dali
发表日期：2022
文献求助 收藏

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

(S)-3-氨基-4-(二氟亚甲基基)环己-1-烯-1-羧酸作为人鸟氨酸氨基转移酶选择性灭活剂的显著且出乎意料的机制

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.1c03572
Zhu, Wei; Doubleday, Peter F; Butrin, Arseniy; Weerawarna, Pathum M; Melani, Rafael D; Catlin, Daniel S; Dwight, Timothy A; Liu, Dali; Kelleher, Neil L; Silverman, Richard B
Human
发表日期：2021
文献求助 收藏

Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF(3))

结构和动力学分析揭示了 (1S,3S)-3-氨基-4-(六氟丙烷-2-亚基)-环戊烷-1-羧酸 (BCF(3)) 对鸟氨酸氨基转移酶的双重抑制模式

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.0c00728
Butrin, Arseniy; Beaupre, Brett A; Kadamandla, Noel; Zhao, Peidong; Shen, Sida; Silverman, Richard B; Moran, Graham R; Liu, Dali
发表日期：2021
文献求助 收藏

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

一个氟原子对两种γ-氨基丁酸环己烯类似物灭活人鸟氨酸氨基转移酶机制的显著影响

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.0c00193
Zhu, Wei; Doubleday, Peter F; Catlin, Daniel S; Weerawarna, Pathum M; Butrin, Arseniy; Shen, Sida; Wawrzak, Zdzislaw; Kelleher, Neil L; Liu, Dali; Silverman, Richard B
Human
发表日期：2020
文献求助 收藏