日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual mechanism of the OXA-23 carbapenemase inhibition by the carbapenem NA-1-157

碳青霉烯类抗生素NA-1-157对OXA-23碳青霉烯酶的双重抑制机制

Toth, Marta; Stewart, Nichole K; Quan, Pojun; Khan, Md Mahbub Kabir; Cox, Jonathan; Buynak, John D; Smith, Clyde A; Vakulenko, Sergei B

Novel C5α-substituted carbapenems enhance Mycobacterium abscessus killing via selective target binding and reduced hydrolysis by Bla(Mab)

新型 C5α 取代的碳青霉烯类抗生素通过选择性靶标结合和减少 Bla(Mab) 水解作用增强对脓肿分枝杆菌的杀灭作用。

Shin, Eunjeong; Taracila, Magdalena A; Quan, Pojun; Khan, Md Mahbub Kabir; Cox, Jonathan; Patel, Diya; Dousa, Khalid M; Parmar, Aetan; Nantongo, Mary; Nguyen, David C; Rubin, Eric J; Holland, Steven M; Kreiswirth, Barry N; Buynak, John D; Bonomo, Robert A

Randomized, Open-Label Phase 3 Study Evaluating Immunogenicity, Safety, and Reactogenicity of RSVPreF3 OA Coadministered with FLU-QIV-HD in Adults Aged ≥ 65

一项随机、开放标签的3期研究,旨在评估RSVPreF3 OA与FLU-QIV-HD联合用药在≥65岁成年人中的免疫原性、安全性和反应原性。

Buynak, Robert; Cannon, Kevin; DeAtkine, David; Kirby, John; Usdan, Lisa; Bhavsar, Amit; Gérard, Catherine; Kuznetsova, Anastasia; Jayadev, Amulya; Amare, Hiwot; Valenciano, Sofia; Meyer, Nadia

Decarboxylation of the Catalytic Lysine Residue by the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the OXA-58 Carbapenemase

C5α-甲基取代的碳青霉烯类抗生素NA-1-157通过催化赖氨酸残基的脱羧作用,有效抑制OXA-58碳青霉烯酶的活性。

Toth, Marta; Stewart, Nichole K; Maggiolo, Ailiena O; Quan, Pojun; Khan, Md Mahbub Kabir; Buynak, John D; Smith, Clyde A; Vakulenko, Sergei B

Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp

亚胺培南、美罗培南、头孢吡肟和舒巴坦联合β-内酰胺酶抑制剂LN-1-255对不动杆菌属的活性

Lasarte-Monterrubio, Cristina; Vázquez-Ucha, Juan C; Maneiro, Maria; Arca-Suárez, Jorge; Alonso, Isaac; Guijarro-Sánchez, Paula; Buynak, John D; Bou, Germán; González-Bello, Concepción; Beceiro, Alejandro

Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors

非典型修饰的卡巴培南类抗生素在没有 β-内酰胺酶抑制剂的情况下表现出增强的抗分枝杆菌活性

Rashmi Gupta, Noora M S A Al-Kharji, Maha A Alqurafi, Thu Q Nguyen, Weirui Chai, Pojun Quan, Riya Malhotra, Breven S Simcox, Phil Mortimer, Leighanne A Brammer Basta, Kyle H Rohde, John D Buynak

Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii

β-内酰胺酶抑制剂 LN-1-255 对鲍曼不动杆菌卡巴培南水解 D 类 β-内酰胺酶的活性

Juan Carlos Vázquez-Ucha, María Maneiro, Marta Martínez-Guitián, John Buynak, Christopher R Bethel, Robert A Bonomo, Germán Bou, Margarita Poza, Concepción González-Bello, Alejandro Beceiro

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48

LN-1-255 是一种青霉烷酸砜,能够抑制 D 类碳青霉烯酶 OXA-48。

Vallejo, Juan A; Martínez-Guitián, Marta; Vázquez-Ucha, Juan C; González-Bello, Concepción; Poza, Margarita; Buynak, John D; Bethel, Christopher R; Bonomo, Robert A; Bou, German; Beceiro, Alejandro

Functionalizing the γ-Position of α-Diazo-β-ketoesters

α-重氮-β-酮酯γ位官能化

Nguyen, Thu Q; Alqurafi, Maha; Edwards, Cash; Nguyen, Pauline; Kim, Jean; Casco, Samuel; Bennet, Maricka; Chiang, Christopher; Lohry, Maureen; Cox, Melina; Meshram, Byron; Le, Duyen; Kim, Eugene; Smriti, Snigdha; Oelschlaeger, Peter; Buynak, John D

Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis

在IMP-25金属β-内酰胺酶催化的水解过程中观察到美罗培南和色甘酸钠的中间体

Oelschlaeger, Peter; Aitha, Mahesh; Yang, Hao; Kang, Joon S; Zhang, Antonia L; Liu, Eleanor M; Buynak, John D; Crowder, Michael W