Ibogalogs induce antiseizure activity in rodents by a mechanism involving 5-HT(2A/2C) receptor activation with a major role of 5-HT(2A) receptors in the hippocampal CA3 subfield
伊博加洛酮类药物通过激活5-HT(2A/2C)受体的机制在啮齿动物中诱导抗癫痫活性,其中海马CA3亚区的5-HT(2A)受体起主要作用。
期刊:Biochemical Pharmacology
影响因子:5.6
doi:10.1016/j.bcp.2026.117799
Chagraoui, Abdeslam; Kazmierska-Grebowska, Paulina; Byache, Olivia; Abraham, Alejandro; Rudin, Deborah; Caban, Bartosz; Kowalczyk, Tomasz; Liechti, Matthias E; Wacker, Daniel; Aman, Chloé; Deurwaerdère, Philippe De; Arias, Hugo R