The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain.
碳酸酐酶抑制剂甲唑胺可防止β淀粉样蛋白诱导的线粒体功能障碍和半胱天冬酶激活,从而在体外和鼠脑中保护神经元和胶质细胞
期刊:Neurobiology of Disease
影响因子:5.6
doi:10.1016/j.nbd.2015.11.006
Fossati Silvia, Giannoni Patrizia, Solesio Maria E, Cocklin Sarah L, Cabrera Erwin, Ghiso Jorge, Rostagno Agueda