日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneity

一种用于评估核心针穿刺活检中免疫疗法反应的活体肿瘤碎片平台,同时应对肿瘤异质性带来的挑战

Ramasubramanian, T S; Adstamongkonkul, Pichet; Scribano, Christina M; Johnson, Christin; Caenepeel, Sean; Hrycyniak, Laura C F; Vedder, Lindsey C; Dana, Nicholas; Baltes, Christian; Browning, Victoria; Chen, Yuan-I; Dietz, Thomas; Flietner, Evan; Kaplewski, Nicholas; Kellner, Anna; Korrer, Michael; Liu, Chao; Marhefke, Nathan; McDonnell, Payton; Nasreen, Amreen; Pope, Victoria; Prasad, Abhijeet; Richardson, Jordyn; Schneider, Sidney; Schultz, Mikaela M; Sood, Chetan; Sunil, Aishwarya; Euw, Erika von; Wait, Eric; Wargowski, Ellen E; Advani, Pooja; Broome, Barbara; Bruckbauer, Antje; Godwin, Andrew; Kokabi, Nima; Lou, Yanyan; Martin, Robert C G 2nd; Robaina, Mercedes; Toia, Giuseppe; Routh, Joshua; Friedl, Andreas; Eliceiri, Kevin; Szulczewski, Michael; Johnson, Scott; Oliner, Jon; Galon, Jérôme; Capitini, Christian; Mukhopadhyay, Debabrata; Taube, Janis; Braun, David; Gierman, Hinco J

MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens.

通过辅因子导向的DNA编码文库筛选得到的MTA协同PRMT5抑制剂

Andersson Jan, Cowland Sanne, Vestergaard Mikkel, Yang Yajing, Liu Siyuan, Fang Xie, Mukund Susmith, Ghimire-Rijal Sudipa, Carter Chris, Chung Grace, Jacso Tomas, Sarvary Ian, Hughes Paul E, Gouliaev Alex, Payton Marc, Belmontes Brian, Caenepeel Sean, Franch Thomas, Glad Sanne, Husemoen Birgitte, Nielsen Søren Jensby

From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.

从 DNA 编码文库筛选到 AM-9747:一种具有强效口服体内疗效的 MTA 协同 PRMT5 抑制剂

Sarvary Ian, Vestergaard Mikkel, Moretti Loris, Andersson Jan, Peiró Cadahía Jorge, Cowland Sanne, Flagstad Thomas, Franch Thomas, Gouliaev Alex, Husemoen Gitte, Jacso Tomas, Kronborg Titi, Kuropatnicka Aleksandra, Nadali Anna, Madsen Mads, Nielsen So Ren, Pii David, Ryborg So Ren, Soede Camillia, Allen Jennifer R, Bourbeau Matthew, Li Kexue, Liu Qingyian, Lo Mei-Chu, Madoux Franck, Mardirossian Narbe, Moriguchi Jodi, Ngo Rachel, Peng Chi-Chi, Pettus Liping, Tamayo Nuria, Wang Paul, Kapoor Rajiv, Belmontes Brian, Caenepeel Sean, Hughes Paul, Liu Siyuan, Slemmons Katherine K, Yang Yajing, Xie Fang, Ghimire-Rijal Sudipa, Mukund Susmith, Glad Sanne

A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneity

一种用于评估核心针穿刺活检中免疫疗法反应的活体肿瘤碎片平台,同时应对肿瘤异质性带来的挑战

Ramasubramanian, T S; Adstamongkonkul, Pichet; Scribano, Christina M; Johnson, Christin; Caenepeel, Sean; Hrycyniak, Laura C F; Vedder, Lindsey; Dana, Nicholas; Baltes, Christian; Browning, Torey; Chen, Yuan-I; Dietz, Thomas; Flietner, Evan; Kaplewski, Nicholas; Kellner, Anna; Korrer, Michael; Liu, Chao; Marhefke, Nathan; McDonnell, Payton; Nasreen, Amreen; Pope, Victoria; Prasad, Abhijeet; Richardson, Jordyn; Schneider, Sidney; Schultz, Mikaela; Sood, Chetan; Sunil, Aishwarya; von Euw, Erika; Wait, Eric; Wargowski, Ellen; Advani, Pooja; Broome, Barbara; Bruckbauer, Antje; Godwin, Andrew; Kokabi, Nima; Martin, Robert; Robaina, Mercedes; Toia, Giuseppe; Routh, Joshua; Friedl, Andreas; Eliceiri, Kevin; Szulczewski, Mike; Johnson, Scott; Oliner, Jon; Galon, Jérôme; Capitini, Christian; Mukhopadhyay, Debabrata; Taube, Janis; Braun, David; Gierman, Hinco J

Targeting MCL-1 in hematologic malignancies: Rationale and progress

靶向MCL-1治疗血液系统恶性肿瘤:理论基础及进展

Wei, Andrew H; Roberts, Andrew W; Spencer, Andrew; Rosenberg, Aaron Seth; Siegel, David; Walter, Roland B; Caenepeel, Sean; Hughes, Paul; McIver, Zach; Mezzi, Khalid; Morrow, Phuong Khanh; Stein, Anthony

Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma

血管生成素-TIE2和MET的双重抑制可改变肾细胞癌转移模型中的肿瘤微环境并延长生存期

Elbanna, May; Orillion, Ashley R; Damayanti, Nur P; Adelaiye-Ogala, Remi; Shen, Li; Miles, Kiersten Marie; Chintala, Sreenivasulu; Ciamporcero, Eric; Ramakrishnan, Swathi; Ku, Sheng-Yu; Rex, Karen; Caenepeel, Sean; Coxon, Angela; Pili, Roberto

MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor

MAPK通路抑制可诱导MET和GAB1水平升高,从而使BRAF突变型黑色素瘤更容易受到肝细胞生长因子的拯救。

Caenepeel, Sean; Cooke, Keegan; Wadsworth, Sarah; Huang, Guo; Robert, Lidia; Moreno, Blanca Homet; Parisi, Giulia; Cajulis, Elaina; Kendall, Richard; Beltran, Pedro; Ribas, Antoni; Coxon, Angela; Hughes, Paul E

Identifying the determinants of response to MDM2 inhibition.

确定MDM2抑制反应的决定因素

Saiki Anne Y, Caenepeel Sean, Cosgrove Elissa, Su Cheng, Boedigheimer Michael, Oliner Jonathan D

Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody

血管生成素-1抑制在抑制血管生成和肿瘤生长中的作用具有情境依赖性:对血管生成素-1/2中和肽抗体AMG 386的启示

Coxon, Angela; Bready, James; Min, Hosung; Kaufman, Stephen; Leal, Juan; Yu, Dongyin; Lee, Tani Ann; Sun, Ji-Rong; Estrada, Juan; Bolon, Brad; McCabe, James; Wang, Ling; Rex, Karen; Caenepeel, Sean; Hughes, Paul; Cordover, David; Kim, Haejin; Han, Seog Joon; Michaels, Mark L; Hsu, Eric; Shimamoto, Grant; Cattley, Russell; Hurh, Eunju; Nguyen, Linh; Wang, Shao Xiong; Ndifor, Anthony; Hayward, Isaac J; Falcón, Beverly L; McDonald, Donald M; Li, Luke; Boone, Tom; Kendall, Richard; Radinsky, Robert; Oliner, Jonathan D