日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

蛋白偏向的小分子 Apelin 激动剂 CMF-019 可在体外改善内皮细胞凋亡，并在体内诱导血管扩张而不产生脱敏作用

期刊:Frontiers in Pharmacology
影响因子:4.4
doi:10.3389/fphar.2020.588669
Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E Kuc, Thomas L Williams, Christopher M Fitzpatrick, Richard Foster, Robert C Glen, Janet J Maguire, Anthony P Davenport
免疫
细胞生物学
内皮细胞
Apoptosis
发表日期：2021
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G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists

产生持续 G 蛋白激活的 G 蛋白信号偏向性 μ 阿片受体激动剂是非竞争性激动剂

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.2102178118
Edward L Stahl, Cullen L Schmid, Agnes Acevedo-Canabal, Cai Read, Travis W Grim, Nicole M Kennedy, Thomas D Bannister, Laura M Bohn
信号转导
发表日期：2021
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A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

一种新型的阿扑素受体周期性偏向激动剂 MM07 可在大鼠肺动脉高压野百合碱模型中改善病情

期刊:British Journal of Pharmacology
影响因子:6.8
doi:10.1111/bph.14603
Peiran Yang, Cai Read, Rhoda E Kuc, Duuamene Nyimanu, Thomas L Williams, Alexi Crosby, Guido Buonincontri, Mark Southwood, Stephen J Sawiak, Robert C Glen, Nicholas W Morrell, Anthony P Davenport, Janet J Maguire
Cell Culture
Human
发表日期：2019
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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

Elabela/Toddler 是成人心血管系统中 Apelin APJ 受体的内源性激动剂，外源性肽给药可补偿肺动脉高压中其表达的下调

期刊:Circulation
影响因子:35.5
doi:10.1161/CIRCULATIONAHA.116.023218
Peiran Yang, Cai Read, Rhoda E Kuc, Guido Buonincontri, Mark Southwood, Rubben Torella, Paul D Upton, Alexi Crosby, Stephen J Sawiak, T Adrian Carpenter, Robert C Glen, Nicholas W Morrell, Janet J Maguire, Anthony P Davenport
信号转导
发表日期：2017
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Cardiac action of the first G protein biased small molecule apelin agonist

第一个 G 蛋白偏向小分子阿扑素激动剂的心脏作用

期刊:Biochemical Pharmacology
影响因子:5.3
doi:10.1016/j.bcp.2016.07.018
Cai Read, Christopher M Fitzpatrick, Peiran Yang, Rhoda E Kuc, Janet J Maguire, Robert C Glen, Richard E Foster, Anthony P Davenport
信号转导
发表日期：2016
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Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

在人类和大鼠血管中，趋化因子样受体 1 (CMKLR1) 而非 G 蛋白偶联受体 1 (GPR1) 引发强效收缩作用

期刊:Journal of the American Heart Association
影响因子:5
doi:10.1161/JAHA.116.004421
Amanda J Kennedy, Peiran Yang, Cai Read, Rhoda E Kuc, Lucy Yang, Emily J A Taylor, Colin W Taylor, Janet J Maguire, Anthony P Davenport
信号转导
Human
发表日期：2016
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